Nos projets de recherche

Disponible en anglais seulement

Mise à jour février 2025

Title Principal Investigator / Supervisor Program Trier par ordre décroissant Project Start Date Project End Date Total $ Awarded
Assessing the relationship between red blood cell deformability and transfusion lifetime Principal Investigator: MA, Hongshen

Co-Investigator(s) / Trainee: LAMOUREUX, Erik
Graduate Fellowship Program $122,000
Dengue virus replication by anucleate cells: impact on pathogen reduction efficacy Principal Investigator: PRYZDIAL, Ed

Co-Investigator(s) / Trainee: FELGENHAUER, Ulrike
Graduate Fellowship Program $52,000
Deformability based cell sorting enabling quality control of stored red blood cells Principal Investigator: MA, Hongshen

Co-Investigator(s) / Trainee: ISLAMZADA, Emel
Graduate Fellowship Program $112,333
Defining the stem cell regulatory functions of GAS6 and FTO Principal Investigator: MAGANTI, Harinad

Co-Investigator(s) / Trainee: PASALA, Ajay
Graduate Fellowship Program $122,000
Identification of protein biomarkers for red cell quality Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: CHEN, Deborah
Graduate Fellowship Program $100,000
Platelet desialylation: novel mechanism of platelet clearance and immune tolerance Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee: LI, June
Graduate Fellowship Program $104,000
A novel clot-dissolving agent derived from clotting factor Va Principal Investigator: PRYZDIAL, Ed

Co-Investigator(s) / Trainee: LEE, Frank
Graduate Fellowship Program $39,500
Generation of a coagulation factor-based thrombotic agent Principal Investigator: PRYZDIAL, Ed

Co-Investigator(s) / Trainee: WITT, Alexandra
Graduate Fellowship Program $122,000
The in vivo effects of liposome treatment on minimizing membrance injury in rat red blood cells during hypothermic storage Principal Investigator: HOLOVATI, Jelena

Co-Investigator(s) / Trainee: da SILVIERA CAVALCANTE, Luciana
Graduate Fellowship Program $100,000
Small molecule ice recrystallization inhibitors as cryo-additives for red blood cell cryopreservation Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: POISSON, Jessica
Graduate Fellowship Program $82,000
Monoclonal antibodies with anti-D like activity in amelioration of murine ITP Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: KHAN, Ramsha
Graduate Fellowship Program $52,000
Modified platelet storage containers to improve quality during storage Principal Investigator: KIZHAKKEDATHU, Jayachandran

Co-Investigator(s) / Trainee: PEREYRA DOS SANTOS, Nicolas
Graduate Fellowship Program $122,000
MRI guided focused ultrasound facilitated IVIg immunotherapy as a therapeutic approach for Alzheimer's disease Principal Investigator: AUBERT, Isabelle

Co-Investigator(s) / Trainee: DUBEY, Sonam
Graduate Fellowship Program $100,000
Improving pathogen inactivation: the dengue virus-induced platelet proteome Principal Investigator: PRYZDIAL, Ed

Co-Investigator(s) / Trainee: TEGEGN, Tseday Zewdu
Graduate Fellowship Program $104,000
New solution for cord blood unit preservation Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: KAUSHAL, Richa
Graduate Fellowship Program $116,500
CD71 Erythroid Cells, RBC Clearance and Sepsis in Donor - Recipient Sex- Mismatched Transfusion Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: LI, Wenhui
Graduate Fellowship Program $70,000
Fc receptor blockade related to fetal and neonatal alloimmune thrombocytopenia Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: TAWHIDI, Zoya
Graduate Fellowship Program $70,000
Characterization of the role of MSI2 in human hematopoietic stem cell self-renewal Principal Investigator: HOPE, Kristin

Co-Investigator(s) / Trainee: RENTAS, Stefan
Graduate Fellowship Program $100,000
Studying and alleviating the effects of platelet microparticles induced by pathogen reduction of platelet concentrates Principal Investigator: PROVOST, Patrick

Co-Investigator(s) / Trainee: LAUGIER, Jonathan
Graduate Fellowship Program $52,000
Synthesis and live cell imaging of ice recrystallization inhibitors in red blood cells Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: MCMUNN, Leah
Graduate Fellowship Program $112,333
Anemia-induced bleeding in thrombocytopenic patients with blood cancer Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: MODI, Dimpy
Graduate Fellowship Program $70,000
Replacing plasma-derived C1 Esterase inhibitor Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: SIVANANTHAN, Sangavi
Graduate Fellowship Program $70,000
Investigation of pathophysiology, prevention and treatment of murine Transfusion Related Acute Lung Injury (TRALI) Principal Investigator: SEMPLE, John

Co-Investigator(s) / Trainee: McVEY, Mark
Graduate Fellowship Program $52,000
Investigating the mechanism of anti-CD44 antibody amelioration of IVIg-treatable disease Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: NORRIS, Peter
Graduate Fellowship Program $104,000
Replacement of IVIg by small molecule inhibitors of phagocytosis Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: LORIAMINI, Melika
Graduate Fellowship Program $112,333
Management of critical bleeding in patients with immune thrombocytopenia Principal Investigator: GUYATT, Gordon

Co-Investigator(s) / Trainee: CHOWDHURY, Saifur
Graduate Fellowship Program $70,000
Cellular therapy to improve CD4+ T-Cell responses in humanized mice infected with HIV-1: adoptive transfer of CD4+ T-cells lacking s-Src activity Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: McCARTHY, Stephen
Graduate Fellowship Program $96,000
Novel cell-surface engineering methods to increase immune-tolerance of allogenic cell transplantation Principal Investigator: KIZHAKKEDATHU, Jayachandran

Co-Investigator(s) / Trainee: MOON, Haisle
Graduate Fellowship Program $82,000
Transcriptome analyses of Staphylococcus aureus grown in platelet concentrates with focus on virulence Principal Investigator: RAMIREZ-ARCOS, Sandra

Co-Investigator(s) / Trainee: DA SILVA PAREDES, Carina
Graduate Fellowship Program $122,000
External validation of a prediction model for diagnosing immune thrombocytopenia Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: MAHAMAD, Syed
Graduate Fellowship Program $70,000
Impact of storage on the function of cord blood hematopoietic stem and progenitor cells Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: JAHAN, Suria
Graduate Fellowship Program $104,000
A multifaceted intervention to optimize red blood cell transfusion practice in two provinces Principal Investigator: WEBERT, Kathryn

Co-Investigator(s) / Trainee: NAHIRNIAK, Susan, CALLUM, Jeannie, LIN, Yulia, ZELLER, Michelle
Intramural Research Grant Program $332,942
The threshold or operative hemoglobin trigger for red blood cell transfustion pilot trial (TOPGUN-pilot) Principal Investigator: MARTEL, Guillaume

Co-Investigator(s) / Trainee: MCISAAC, Daniel, FERGUSSON, Dean, TINMOUTH, Alan, BREAU, Rodney, CARRIER, Francois Martin, VERRET, Michael, TALJAARD, Monica, BROUSSEAU, Karine
Intramural Research Grant Program $400,000
IN-TRUST: Using a transfusion database to explore the immune-modulatory impacts of blood transfusion and the clinical impacts of blood processing changes Principal Investigator: NING, Shuoyan

Co-Investigator(s) / Trainee: ARNOLD, Donald, ZELLER, Michelle, ACKER, Jason, LI, Na, HEDDLE, Nancy, HILLIS, Christopher, ROCHWERG, Bram, SYED, Summer
Intramural Research Grant Program $270,352
Can pre-operative anemia be timely identified and optimized in patients awaiting primary arthroplasty surgery? A randomized clinical trial Principal Investigator: GRAMMATOPOULOS, George

Co-Investigator(s) / Trainee: FERGUSSON, Dean, RAMSAY, Tim, TINMOUTH, Alan, GAGNE, Sylvain, MACK, Johnathan, BELZILE, Etienne, BEALE, Paul, THAVORN, Kednapa, TOUCHIE, Donna, GERMAIN, Genevieve, LAROCHE, Vincent
Intramural Research Grant Program $276,081
Improving blood product quality Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: MA, Hongshen, JOHNSON, James, D'ALESSANDRO, Angelo
Intramural Research Grant Program $304,462
Optimization of monoclonal anti-erythrocyte antibodies for improved immunoprophylaxis in a murine model Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: NI, Heyu
Intramural Research Grant Program $400,000
Accelerating the clinical translation of “off the shelf” NK cell products for immunotherapies Principal Investigator: MAGANTI, Harinad

Co-Investigator(s) / Trainee: JEZIERSKI, Anna, ALLAN, David
Intramural Research Grant Program $300,000
Modulation of biofilm formation, virulence, and antimicrobial resistance by Staphylococcus aureus during platelet storage Principal Investigator: RAMIREZ-ARCOS, Sandra

Co-Investigator(s) / Trainee: SAD, Subash, MAH, Thien-Fah
Intramural Research Grant Program $323,253
Controlling coagulopathy and bleeding in a mouse model of hemorrhagic shock Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: NAZY, Ishac
Intramural Research Grant Program $274,854
Influence of eryptosis and storage on transfused red cell recovery in sepsis Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: BRANCH, Donald, LIAW, Patricia, HEDDLE, Nancy, QADRI, Syed
Intramural Research Grant Program $283,569
Facilitating RBC-mediated Nitric Oxide Release and Boosting Antioxidant Capacity during Ex Vivo Heart Perfusions as a Strategy to Improve Oxygen Delivery Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: FREED, Darren
Intramural Research Grant Program $377,997
New cryosolution for stem cell-based therapeutics Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: BEN, Robert, HARPER, Marie-Ellen, CHAKRABORTY, Nilay
Intramural Research Grant Program $180,000
Residual risk of transfusion-transmitted cytomegalovirus infection: incidence and pathogenesis Principal Investigator: PREIKSAITIS, Jutta

Co-Investigator(s) / Trainee: O'BRIEN, Sheila F., FEARON, Margaret, NAHIRNIAK, Susan
Intramural Research Grant Program $260,451
Biomarkers in patients with anemia-induced thrombocytopenic bleeding (BAIT): A pilot study Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: WEBERT, Kathryn, LIAW, Patricia, BERG, Tobias, HEDDLE, Nancy
Intramural Research Grant Program $200,000
Monovalent Fc receptor blockade using novel fusion proteins: The road towards an IVIg replacement Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: SHEFFIELD, William, BRANCH, Donald
Intramural Research Grant Program $400,000
Improving platelet storage and blood transfusion: unveiling the role of apolipoprotein A-IV Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee: LAZARUS, Alan, BRANCH, Donald
Intramural Research Grant Program $400,000
Enabling next generation hematopoietic-based therapeutics and manufacturing Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: MCCOMB, Scott, JEZIERSKI, Anna, MAGALHAES, Ana, IQBAL, Umer
Intramural Research Grant Program $300,000
Antibodies to CD44 as a potential replacement for IVIg in ITP Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: SEMPLE, John W., SHEFFIELD, William
Intramural Research Grant Program $300,000
Fc receptor blockade in transfusion medicine Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: NI, Heyu, GUPTA, Akash, SHEHATA, Nadine, KJELDSEN-KRAGH, Jens, NEWMAN, Peter J., CSERTI-GAZDEWICH, Christine, RAVETCH, Jeffery
Intramural Research Grant Program $400,000