Plasma residues enhance bacterial attachment to platelet storage bags

What is this research about?


Platelet concentrates (PCs) are derived from blood donors and consist of platelets suspended in plasma. PCs are transfused into patients with bleeding disorders. The greatest safety threat involved with PC transfusion is bacterial contamination. Staphylococcus epidermidis, a bacterium normally found on human skin, is the main PC contaminant. S. epidermidis can stick to the inner walls of PC storage bags, forming attached bacterial colonies known as biofilms that prevent detection of the bacteria during routine PC bacteria screening performed on a small sample of the liquid product. Approximately 1 in 3,000 PC units are contaminated with bacteria.


In brief: Bacterial attachment inside platelet concentrate bags is enhanced by plasma residues and is not altered by the type of storage bags used.

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