Ni, Heyu

Selected Publications
  1. Hou Y, Carrim N, Wang Y, Gallant RC, Marshall AH, Ni H: Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis. J Biomed Res 2015; doi: 10.7555/JBR.29.20150121 [Epub ahead of print].
  2. Wang Y, Reheman A, Spring CM, Kalantari J, Marshall AH, Wolberg AS, Gross PL, Weitz JI, Rand ML, Mosher DF, Freedman J, Ni H: Plasma fibronectin supports hemostasis and regulates thrombosis. J Clin Invest 2014; 124:4281-4293.
  3. Reheman A, Xu X, Reddy E, Ni H: Targeting activated platelets and fibrinolysis: hitting two birds with one stone. Circ Res 2014; 114:1070-1073.
  4. Fedorov K, Blaszykowski C, Sheikh S, Reheman A, Romaschin A, Ni H, Thompson M: Prevention of thrombogenesis from whole human blood on plastic polymer by ultrathin monoethylene glycol silane adlayer. Langmuir 2014; 30:3217-3222.
  5. Lei X, Reheman A, Hou Y, Zhou H, Wang Y, Marshall AH, Liang C, Dai X, Li BX, Vanhoorelbeke K, Ni H: Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis. Thromb Haemost 2014; 111:279-289.
  6. Murphy AJ, Bijl N, Yvan-Charvet L, Welch CB, Bhagwat N, Reheman A, Wang Y, Levine R, Ni H, Tall AR, Wang N: Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombosis. Nat Med. 2013; 19:586-594.
  7. Wang Y, Andrews M, Lang S, Jin JW, Cameron-Vendrig A, Zhu G, Reheman A, Ni H: Platelets in Thrombosis and Hemostasis: Old Topic with New Mechanisms. Cardiovascular & Haematological Disorders - Drug Targets 2012; 12:126-132.
  8. Dunne E, Spring CM, Reheman A, Jin W, Berndt MC, Newman DK, Newman PJ, Ni H Kenny D: Cadherin 6 has a functional role in platelet aggregation and thrombus formation. Arterioscl Throm Vas 2012; 32:1724-1731.
  9. Patel S, Huang YW, Reheman A, Pluthero FG, Chaturvedi S, Mukovozov IM, Tole S, Liu GY, Li L, Durocher Y, Ni H, Kahr WH, Robinson LA: The cell motility modulator Slit2 is a potent inhibitor of platelet function. Circulation 2012; 126:1385-1395.
  10. Yang Y, Shi Z, Reheman A, Jin JW, Li C, Wang Y, Andrews MC, Chen P, Zhu G, Ling W, Ni H: Plant food delphinidin-3-glucoside significantly inhibits platelet activation and thrombosis: Novel protective roles against cardiovascular diseases. PLoS One 2012;7:e37323.
Selected Publications
  1. Li J, van der Wal DE, Zhu G, Xu M, Yougbaré I, Ma L, Vadasz B, Carrim N, Grozovsky R, Ruan M, Zhu L, Zeng Q, Tao L, Zhai ZM, Peng J, Hou M, Leytin V, Freedman J, Hoffmeister KM, Ni H: Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia. Nat Commun2015; 6:7737.
  2. Yougbaré I, Lang S, Yang H, Chen P, Zhao X, Tai WS, Zdravic D, Vadasz B, Li C, Piran S, Marshall A, Zhu G, Tiller H, Killie MK, Boyd S, Leong-Poi H, Wen XY, Skogen B, Adamson SL, Freedman J, Ni H: Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage. J Clin Invest 2015; 125:1545-1556.
  3. Ma L, Simpson E, Li J, Xuan M, Xu M, Baker L, Shi Y, Yougbaré I, Wang X, Zhu G, Chen P, Prud’homme G, Lazarus AH, Freedman J, Ni H: CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia. Blood 2015; 126:247-256.
  4. Ni H: ResearchUnit: Novel discovery reveals new diagnostic markers and treatment targets for bleeding disorder. 2015; Transfusionmedicine.ca website.
  5. Ni H: ResearchUnit: Platelets vs. blood vessels: What causes bleeding in fetuses and newborns with FNAIT? 2015; Transfusionmedicine.ca website.
  6. Li J, Callum JL, LinY, Zhou Y, Zhu G, Ni H: Severe platelet desialylation in a patient with glycoprotein Ib/IX antibody-mediated immune thrombocytopenia and fatal pulmonary hemorrhage. Haematologica 2014; 99:e61-63.
  7. Peng J, Ma S‐H, Liu J, Hou Y, Liu X‐M, Niu T, Xu R‐R, Guo C‐S, Wang X‐M, Cheng Y‐F, Ni H, Hou M: Association of autoantibody specificity and response to intravenous immunoglobulin G therapy in immune thrombocytopenia: a multicenter cohort study. J Thromb Haemost 2014; 12:497-504.
  8. Guo L, Yang L, Speck E, Aslam R, Kim M, McKenzie C, Lazarus A, Ni H, Hou M, Freedman J, Semple J: Allogeneic platelet transfusions prevent murine T cell-mediated immune thrombocytopenia (ITP). Blood 2014; 123:422-427.
  9. Li C, Chen P, Zhou H, Vadasz B, Ma L, Lang S, Freedman J, Ni H: Co-stimulation with lipopolysaccharide or polyinosinic: polycytidylic acid enhances the immune response against platelet antigens in murine models of fetal and neonatal alloimmune thrombocytopenia. Thromb Haemostasis 2013; 110:1250-1258.
  10. Ni H: Influence of the anticoagulant on detection of the ITP anti-platelet GPIIb/IIIa and GPIbalpha antibodies on based modified MAIPA. Acta Universitatis Medicinalis Anhui 2013; 48:832-834.
  11. Nishimoto T, Satoh T, Simpson EK, Ni H, Kuwana M: Predominant autoantibody response to GPIb/IX in a regulatory T-cell-deficient mouse model for immune thrombocytopenia. J Thromb Haemost 2013; 11:369-372.
  12. Aslam R, Hu Y, Gebremeskel S, Segel GB, Speck ER, Guo L, Kim M, Ni H, Freedman J, Semple JW: Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia (ITP). Blood 2012; 120:2127-2132.
  13. Tiller H, Kjaer Killie M, Chen P, Eksteen M, Husebekk A, Skogen B, Kjeldsen‐Kragh J, Ni H: Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: induction of antibody‐mediated immune suppression and prevention of severe clinical complications in a murine model. Transfusion 2012; 52:1446-1457.

Leadership Roles

 

Click to see Leadership Roles:
2011 - CurrentCouncil Committee Member, International Society of Thrombosis and Haemostasis
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