Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Influence of polymer architecture on antigens camouflage, CD47 protection and complement mediated lysis of surface grafted red blood cells Chapanian R, Constantinescu I, Rossi NA, Medvedev N, Brooks DE, Scott MD, Kizhakkedathu JN 2012 Biomaterials View Researchers Basic research
MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activity Saha MN, Jiang H, Jayakar J, Reece D, Branch DR, Chang H 2010 Cancer Biol Ther View Researchers Basic research
Nouvelle cuisine: platelets served with inflammation Kapur R, Zufferey A, Boilard E, Semple JW 2015 J Immunol View Researchers Basic research
Targeting activated platelets and fibrinolysis: hitting two birds with one stone Reheman A, Xu X, Reddy EC, Ni H 2014 Circ Res View Researchers Basic research
Screening of red blood cells for extracellular vesicle content as a product quality indicator Acker JP, Almizraq RJ, Millar D, Maurer-Spurej E 2018 Transfusion View Researchers New or improved product or process
Anti-M (French) Clarke G, Cote J, Lane D 2018 Blood.ca website View Researchers Basic research
Concentré de recherche : Dépistage d'agents pathogènes : la modélisation du risque au service de la sécurité de l'approvisionnement en sang O'Brien S 2019 Blood.ca website View Researchers Basic research
Cross-linked hemoglobin bis-tetramers from bioorthogonal coupling do not induce vasoconstriction in the circulation Wang A, Singh S, Yu B, Bloch DB, Zapol WM, Kluger R 2019 Transfusion View Researchers Basic research
Bacterial survival in whole blood depends on plasma sensitivity and resistance to neutrophil killing Taha M, Kyluik-Price D, Kumaran D, Scott MD, Toyofuku W, Ramirez-Arcos S 2019 Transfusion View Researchers Basic research
Implications of variability in cell membrane permeability for design of methods to remove glycerol from frozen-thawed erythrocytes Lahmann JM, Sanchez CC, Benson JD, Acker JP, Higgins AZ 2020 Cryobiology View Researchers Basic research
Stability of 40 cytokines/chemokines in chronically ill patients under different storage conditions Binnington B, Sakac D, Yi Q, Tong TN, Parmar N, Duong TT, Yeung RSM, Pendergrast J, Branch DR 2020 Cytokine View Researchers Basic research
50 years of Vox Sanguinis International Forums Lozano M, Dunbar NM, Devine DV 2020 Vox Sang View Researchers Benchmarking and standard setting
Could antigen loss be a potential mechanism to explain antibody-mediated immune suppression? Cruz-Leal Y, Lazarus AH 2021 Transfusion View Researchers Basic research
Evaluating blood product quality post expiry to mitigate blood shortages during the COVID-19 pandemic in Canada Turner TR, Olafson C, Mykhailova O, Xu A, Acker JP 2020 Transfusion View Researchers New or improved product or process
Industry, experts and the role of the ‘invisible college’ in the dissemination of non-invasive prenatal testing in the US Holloway K, Miller FA, Simms N 2021 Soc Sci Med View Researchers Ethical, legal and social implications research
Revisiting study design and methodology for pathogen reduced platelet transfusions: a round table discussion Heddle NM, Cardoso M, van der Meer PF 2020 Transfusion View Researchers Clinical research
Transient warming affects potency of cryopreserved cord blood units Pasha R, Howell A, Turner TR, Halpenny M, Elmoazzen H, Acker JP, Pineault N 2020 Cytotherapy View Researchers New or improved product or process
Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs Wang A, Ribeiro RVP, Ali A, Brambate E, Abdelnour-Berchtold E, Michaelsen V, Zhang Y, Rahfeld P, Moon H, Gokhale H, Gazzalle A, Pal P, Liu M, Waddell TK, Cserti-Gazdewich C, Tinckam K, Kizhakkedathu JN, West L, Keshavjee S, Withers SG, Cypel M 2022 Sci Transl Med View Researchers Clinical research
Meta-Analysis of Risk of Vaccine-Induced Immune Thrombotic Thrombocytopenia Following ChAdOx1-S Recombinant Vaccine Chan BT, Bobos P, Odutayo A, Pai M 2021 medRxiv View Researchers Clinical research
The Effect of Sex-Mismatched Red Blood Cell Transfusion on Endothelial Cell Activation in Critically Ill Patients Alshalani A, van Manen L, Boshuizen M, van Bruggen R, Acker JP, Juffermans NP 2021 Transfus Med Hemotherapy View Researchers Clinical research
Mixing study to diagnose heparin-resistance caused by functional antithrombin deficiency Bahabri A, Moffat KA, Carlino SA, Chan AKC, Bhatt MD 2022 Int J Lab Hematol View Researchers Basic research
Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner De Silva E, Devine DV, Jan E, Roskelley CD, Kim H 2022 Biochem J View Researchers Basic research
Model of Acute Liver Failure in an Isolated Perfused Porcine Liver—Challenges and Lessons Learned Hefler J, Hatami S, Thiesen A, Olafson C, Durand K, Acker J, Karvellas CJ, Bigam DL, Freed DH, Shapiro AMJ 2022 Biomedicines View Researchers New or improved product or process
Cross-Canada Variability in Blood Donor SARS-CoV-2 Seroprevalence by Social Determinants of Health O’Brien SF, Caffrey N, Yi Q-L, Bolotin S, Janjua NZ, Binka M, Thanh CQ, Stein DR, Lang A, Colquhoun A, Pambrun C, Reedman CN, Drews SJ 2023 Microbiol Spectr View Researchers Clinical research
The response of a human haematopoietic cell line to trehalose-loaded liposomes and their effect on post-thaw membrane integrity Scott KL, William N, Acker JP 2022 Cryobiology View Researchers Basic research
Evaluating variation in perioperative red blood cell transfusion for patients undergoing elective gastrointestinal cancer surgery Zuckerman J, Coburn N, Callum J, Mahar AL, Lin Y, Turgeon AF, McLeod R, Pearsall E, Martel G, Hallet J 2023 Surgery View Researchers Clinical research
[Study on the relationship of platelet specific-autoantibodies with therapeutic outcomes by dexamethasone in immune thrombocytopenia purpura] Chen Y, Ge J, Ruan M, Zhu L, Xie Y, Xia R, Ni H, Zeng Q 2015 Zhonghua Xue Ye Xue Za Zhi View Researchers Clinical research
Advances in umbilical cord blood stem cell expansion and clinical translation Pineault N, Abu-Khader A 2015 Exp Hematol View Researchers Other
Angiogenesis and bleeding disorders in FNAIT Yougbare I, Zdravic D, Ni H 2015 Oncotarget View Researchers Clinical research
Blood bag plasticizers influence red blood cell vesiculation rate without altering the lipid composition of the vesicles Bicalho B, Serrano K, dos Santos Pereira A, Devine D, Acker J 2016 Transfus Med Hemother View Researchers Basic research
Comparison of bacterial attachment to platelet bags with and without preconditioning with plasma Loza-Correa M, Kalab M, Yi QL, Eltringham?Smith L, Sheffield W, Ramirez-Arcos S 2017 Vox Sang View Researchers Basic research
Different doses of prophylactic platelet transfusion for preventing bleeding in patients with haematological disorders after chemotherapy or stem cell transplantation (Protocol) Estcourt LJ, Stanworth S, Doree C, Trivella M, Hopewell S, Murphy MF, Tinmouth A 2014 Cochrane Database Syst Rev View Researchers Clinical research
Effect of liposome-treated red blood cells in an anemic rat model da Silveira Cavalcante L, Feng Q, Chin-Yee I, Acker JP, Holovati JL 2016 J Liposome Res View Researchers Basic research
Erythrocyte saturation with IgG is required for inducing antibody-mediated immune suppression and impacts both erythrocyte clearance and antigen-modulation mechanisms Cruz-Leal Y, Marjoram D, Lazarus AH 2018 J Immunol View Researchers Basic research
Extracellular vesicle characteristics in stored red blood cell concentrates are influenced by the method of detection Almizraq RJ, Seghatchian J, Holovati JL, Acker JP 2017 Transfus Apher Sci View Researchers Basic research
Gender and BCR-ABL transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia Lin HX, Sjaarda J, Dyck J, Stringer R, Hillis C, Harvey M, Carter R, Ainsworth P, Leber B, Pare G, Sadikovic B 2016 Eur J Haematol View Researchers Clinical research
Mesenchymal stromal cells from patients with acute myeloid leukemia have altered capacity to expand differentiated hematopoietic progenitors Chandran P, Le Y, Li Y, Sabloff M, Mehic J, Rosu-Myles M, Allan DS 2015 Leuk Res View Researchers Basic research
Physical Activity and Natural Anti-VIP Antibodies: Potential Role in Breast and Prostate Cancer Therapy Veljkovic M, Dopsaj V, Dopsaj M, Branch DR, Veljkovic N, Sakarellos-Daitsiotis MM, Veljkovic V, Glisic S, Colombatti A 2011 PLoS One View Researchers Basic research
Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis Hou Y, Carrim N, Wang Y, Gallant RC, Marshall A, Ni H 2015 J Biomed Res View Researchers Basic research
Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain Kurbegovic A, Trudel M 2013 Hum Mol Genet View Researchers Basic research
Red blood cell processing methods and in-hospital mortality: a transfusion registry cohort study Heddle NM, Arnold DM, Acker JP, Liu Y, Barty RL, Eikelboom JW, Webert KE, Hsia CC, O'Brien SF, Cook RJ 2016 Lancet Haematol View Researchers Clinical research
Subunit-directed click coupling via doubly cross-linked hemoglobin efficiently produces readily purified functional bis-tetrameric oxygen carriers Singh S, Dubinsky-Davidchik IS, Yang Y, Kluger R 2015 Org Biomol Chem View Researchers Basic research
The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody–mediated amelioration of murine immune thrombocytopenia Crow AR, Suppa SJ, Chen X, Mott PJ, Lazarus AH 2011 Blood View Researchers Basic research
Thrombocytopenia in the critically ill Shehata N, Fontes ML 2013 Can J Anaesth View Researchers Other
Transfusion-transmitted malaria: is hope around the corner? O'Brien SF 2016 Lancet View Researchers Other
Vitamin D and kidney transplant outcomes: a protocol for a systematic review and meta-analysis Hesketh CC, Knoll GA, Molnar AO, Tsampalieros A, Zimmerman DL 2014 Syst Rev View Researchers Clinical research
ResearchUnit: Patient blood group impacts susceptibility to IVIg-associated hemolysis Branch D 2018 Blood.ca website View Researchers Basic research
A Deep Learning Method to Automatically Identify Reports of Scientifically Rigorous Clinical Research from the Biomedical Literature: Comparative Analytic Study Del Fiol G MM, Iorio A, Cotoi C, Haynes RB 2018 J Med Internet Res View Researchers Clinical research
The peptidoglycan and biofilm matrix of Staphylococcus epidermidis undergo structural changes when exposed to human platelets Loza-Correa M, Ayala JA, Perelman I, Hubbard K, Kalab M, Yi Q-L, Taha M, de Pedro MA, Ramirez-Arcos S 2019 PLoS One View Researchers Basic research
Systematic reviews of guidelines and studies for single versus multiple unit transfusion strategies Shih AW, Liu A, Elsharawi R, Crowther MA, Cook RJ, Heddle NM 2018 Transfusion View Researchers Clinical research