Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Synthesis of Highly Biocompatible and Temperature-Responsive Physical Gels for Cryopreservation and 3D Cell Culture Nagao M, Sengupta J, Diaz-Dussan D, Adam M, Wu M, Acker J, Ben R, Ishihara K, Zeng H, Miura Y, Narain R 2018 ACS Appl Bio Mater View Researchers Basic research
Transfusion-related acute lung injury (TRALI) Petraszko T 2019 Blood.ca website View Researchers Clinical research
Virus envelope tissue factor promotes infection in mice Sutherland MR, Simon AY, Shanina I, Horwitz MS, Ruf W, Pryzdial ELG 2019 J Thromb Haemost View Researchers Basic research
Model Human ? Thalassemic Erythrocytes: Effect of Unpaired Purified ?-Hemoglobin Chains on Normal Erythrocytes Scott M 2019 Beta Thalassemia View Researchers Basic research
ResearchUnit: Improving quality testing of stem cells for patients Pineault N 2020 Blood.ca website View Researchers New or improved product or process
Trehalose-Based Polyethers for Cryopreservation and Three-Dimensional Cell Scaffolds Diaz-Dussan D, Peng YY, Sengupta J, Zabludowski R, Adam MK, Acker JP, Ben RN, Kumar P, Narain R 2020 Biomacromolecules View Researchers Basic research
A comparison of methods for prediction of pharmacokinetics when switching to extended half-life products in hemophilia A patients Yu JK, Iorio A, Edginton AN 2020 Thromb Res View Researchers Clinical research
Donor-dependent aging of young and old red blood cell subpopulations: Metabolic and functional heterogeneity Mykhailova O, Olafson C, Turner TR, D?Alessandro A, Acker JP 2020 Transfusion View Researchers Basic research
High subzero cryofixation: A technique for observing ice within tissues Lautner L, William N, Acker JP 2020 Cryobiology View Researchers New or improved product or process
The mega-importance of de novo lipogenesis in platelet production Nazy I, Arnold DM, Steinberg GR 2020 Nat Metab View Researchers Basic research
The impact of extended half-life factor concentrates on patient reported health outcome measures in persons with hemophilia A and hemophilia B Sun HL, Yang M, Poon MC, Lee A, Robinson KS, Sholzberg M, Wu J, Iorio A, Blanchette V, Carcao M, Klaassen RJ, Jackson S 2021 Res Pract Thromb Haemost View Researchers Clinical research
Assessment of bacterial growth in leukoreduced cold-stored whole blood supports overnight hold at room temperature prior to filtration: A pilot study Ramirez-Arcos S, Kou Y, Kumaran D, Culibrk B, Stewart T, Schubert P, McTaggart K 2022 Vox Sang View Researchers New or improved product or process
Heterogeneity of Vaccine-Induced Immune Thrombotic Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination and Safety of Second Vaccination with BNT162b2 Lindhoff-Last E, Schoenborn L, Piorkowski M, Herold J, Greinacher A, Sheppard JA, Warkentin TE 2022 Thromb Haemost View Researchers Clinical research
Blood unit segments accurately represent the biophysical properties of red blood cells in blood bags but not hemolysis Islamzada E, Matthews K, Lamoureux E, Duffy SP, Scott MD, Ma H 2022 Transfusion View Researchers Basic research
Combined preoperative plasma exchange and red blood cell exchange transfusion in a renal transplant patient with protein S deficiency and hemoglobin SC disease Cook O, Cervi A, Laureano M, Gangji AS, Verhovsek M 2021 Transfus Apher Sci View Researchers Clinical research
Concentré de recherche: Suggestion concernant le mécanisme en jeu dans la thrombocytopénie thrombotique induite par le vaccin Batarfi K 2021 Blood.ca website View Researchers Clinical research
Donor-recipient sex is associated with transfusion-related outcomes in critically ill patients Alshalani A, Uhel F, Cremer OL, Schultz MJ, de Vooght KMK, van Bruggen R, Acker JP, Juffermans NP, on behalf of the MARS Consortium 2022 Blood Adv View Researchers Clinical research
Lessons learned from the CONCOR-1 trial Callum J, Bégin P, Jamula E, Liu Y, Kron AT, Auclair MC, Cushing M, Arnold DM 2023 Transfus Med View Researchers Clinical research
A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis Parmar G, Green M, Mostert K, Lawless T, Dibdin N, Weiss J, Ganz K, Petraszko T, Seftel MD, Allan DS 2022 Curr Oncol View Researchers Benchmarking and standard setting
CD4+ T-cells are unable to express the HIV natural resistance factor globotriosylceramide Kim M, Binnington B, Sakac D, Lingwood CA, Branch DR 2013 AIDS View Researchers Basic research
Developing highly active small molecule ice recrystallization inhibitors based upon C-linked antifreeze glycoprotein analogues Trant JF, Briggs RA, Capicciotti C, Ben RN 2013 RSC Adv View Researchers Basic research
Donor iron policy: from research to practice O'Brien SF 2016 Transfusion View Researchers New or improved product or process
Enhanced Cell Surface Polymer Grafting in Concentrated and Nonreactive Aqueous Polymer Solutions Rossi NAA, Constantinescu I, Brooks DE, Scott MD, Kizhakkedathu JN 2010 J Am Chem Soc View Researchers Basic research
Fluids in sepsis and septic shock (FISSH): protocol for a pilot randomised controlled trial Rochwerg B, Millen T, Austin P, Zeller M, D'Aragon F, Jaeschke R, Masse MH, Mehta S, Lamontagne F, Meade M, Guyatt G, Cook DJ 2017 BMJ Open View Researchers Clinical research
Hepatoprotective effects of Poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] on alcohol-damaged primary rat hepatocyte culture in vitro Jiang W, Bian Y, Wang Z, Chang TMS 2016 Artif Cells Nanomed Biotechnol View Researchers New or improved product or process
Immunogenicity, efficacy and safety of Nuwiq® (human-cl rhFVIII) in previously untreated patients with severe haemophilia A-Interim results from the NuProtect Study Liesner RJ, Abashidze M, Aleinikova O, Altisent C, Belletrutti MJ, Borel-Derlon A, Carcao M, Chambost H, Chan AKC, Dubey L, Ducore J, Fouzia NA, Gattens M, Gruel Y, Guillet B, Kavardakova N, El Khorassani M, Klukowska A, Lambert T, Lohade S, Sigaud M, Turea V, Wu JKM, Vdovin V, Pavlova A, Jansen M, Belyanskaya L, Walter O, Knaub S, Neufeld EJ 2017 Haemophilia View Researchers Clinical research
Influence of polymer architecture on antigens camouflage, CD47 protection and complement mediated lysis of surface grafted red blood cells Chapanian R, Constantinescu I, Rossi NA, Medvedev N, Brooks DE, Scott MD, Kizhakkedathu JN 2012 Biomaterials View Researchers Basic research
MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activity Saha MN, Jiang H, Jayakar J, Reece D, Branch DR, Chang H 2010 Cancer Biol Ther View Researchers Basic research
Nouvelle cuisine: platelets served with inflammation Kapur R, Zufferey A, Boilard E, Semple JW 2015 J Immunol View Researchers Basic research
Targeting activated platelets and fibrinolysis: hitting two birds with one stone Reheman A, Xu X, Reddy EC, Ni H 2014 Circ Res View Researchers Basic research
Screening of red blood cells for extracellular vesicle content as a product quality indicator Acker JP, Almizraq RJ, Millar D, Maurer-Spurej E 2018 Transfusion View Researchers New or improved product or process
Anti-M (French) Clarke G, Cote J, Lane D 2018 Blood.ca website View Researchers Basic research
Concentré de recherche : Dépistage d'agents pathogènes : la modélisation du risque au service de la sécurité de l'approvisionnement en sang O'Brien S 2019 Blood.ca website View Researchers Basic research
Cross-linked hemoglobin bis-tetramers from bioorthogonal coupling do not induce vasoconstriction in the circulation Wang A, Singh S, Yu B, Bloch DB, Zapol WM, Kluger R 2019 Transfusion View Researchers Basic research
Bacterial survival in whole blood depends on plasma sensitivity and resistance to neutrophil killing Taha M, Kyluik-Price D, Kumaran D, Scott MD, Toyofuku W, Ramirez-Arcos S 2019 Transfusion View Researchers Basic research
Implications of variability in cell membrane permeability for design of methods to remove glycerol from frozen-thawed erythrocytes Lahmann JM, Sanchez CC, Benson JD, Acker JP, Higgins AZ 2020 Cryobiology View Researchers Basic research
Stability of 40 cytokines/chemokines in chronically ill patients under different storage conditions Binnington B, Sakac D, Yi Q, Tong TN, Parmar N, Duong TT, Yeung RSM, Pendergrast J, Branch DR 2020 Cytokine View Researchers Basic research
50 years of Vox Sanguinis International Forums Lozano M, Dunbar NM, Devine DV 2020 Vox Sang View Researchers Benchmarking and standard setting
Could antigen loss be a potential mechanism to explain antibody-mediated immune suppression? Cruz-Leal Y, Lazarus AH 2021 Transfusion View Researchers Basic research
Evaluating blood product quality post expiry to mitigate blood shortages during the COVID-19 pandemic in Canada Turner TR, Olafson C, Mykhailova O, Xu A, Acker JP 2020 Transfusion View Researchers New or improved product or process
Industry, experts and the role of the ‘invisible college’ in the dissemination of non-invasive prenatal testing in the US Holloway K, Miller FA, Simms N 2021 Soc Sci Med View Researchers Ethical, legal and social implications research
Revisiting study design and methodology for pathogen reduced platelet transfusions: a round table discussion Heddle NM, Cardoso M, van der Meer PF 2020 Transfusion View Researchers Clinical research
Transient warming affects potency of cryopreserved cord blood units Pasha R, Howell A, Turner TR, Halpenny M, Elmoazzen H, Acker JP, Pineault N 2020 Cytotherapy View Researchers New or improved product or process
Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs Wang A, Ribeiro RVP, Ali A, Brambate E, Abdelnour-Berchtold E, Michaelsen V, Zhang Y, Rahfeld P, Moon H, Gokhale H, Gazzalle A, Pal P, Liu M, Waddell TK, Cserti-Gazdewich C, Tinckam K, Kizhakkedathu JN, West L, Keshavjee S, Withers SG, Cypel M 2022 Sci Transl Med View Researchers Clinical research
Meta-Analysis of Risk of Vaccine-Induced Immune Thrombotic Thrombocytopenia Following ChAdOx1-S Recombinant Vaccine Chan BT, Bobos P, Odutayo A, Pai M 2021 medRxiv View Researchers Clinical research
The Effect of Sex-Mismatched Red Blood Cell Transfusion on Endothelial Cell Activation in Critically Ill Patients Alshalani A, van Manen L, Boshuizen M, van Bruggen R, Acker JP, Juffermans NP 2021 Transfus Med Hemotherapy View Researchers Clinical research
Mixing study to diagnose heparin-resistance caused by functional antithrombin deficiency Bahabri A, Moffat KA, Carlino SA, Chan AKC, Bhatt MD 2022 Int J Lab Hematol View Researchers Basic research
Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner De Silva E, Devine DV, Jan E, Roskelley CD, Kim H 2022 Biochem J View Researchers Basic research
Model of Acute Liver Failure in an Isolated Perfused Porcine Liver—Challenges and Lessons Learned Hefler J, Hatami S, Thiesen A, Olafson C, Durand K, Acker J, Karvellas CJ, Bigam DL, Freed DH, Shapiro AMJ 2022 Biomedicines View Researchers New or improved product or process
An evaluation of the clinical impacts of 7-day platelets Ning S, Gabarin N, Li N, Liu Y, Lucier K, Barty R, Acker J, Webert KE, Warkentin TE, Arnold DM, Heddle NM 2023 Transfusion View Researchers Clinical research