Cold- versus room-temperature storage of platelets for bleeding in hematologic malignancy trials (CoVeRTS-HM Trial)

Platelet concentrates may be transfused to prevent bleeding (by increasing the platelet count) or treat bleeding (by providing cells that participate in clot formation). The current standard for storage of platelet concentrates is based on platelet recovery following transfusion, a quantitative measure most relevant for prophylactic platelet transfusions, rather than the function of the transfused platelets. The latter, function, is more important when transfusions are given to treat bleeding. Platelets stored in the cold show features of being more functionally active on laboratory testing compared with platelets stored at room temperature. However, there is very limited data comparing the effect of storage temperature on bleeding outcomes. This project is a feasibility trial that will contribute evidence around the effect of platelet storage temperature on clinically relevant patient outcomes (bleeding) and inform larger clinical trials to improve the utilization of platelet concentrates and help to optimize management of platelet inventories.

MACK, Johnathan

Ottawa Hospital Research Institute

Blood Efficiency Accelerator Program

Ontario

$26,385