Plasma

Research supports equipment change and process improvements


Thursday, August 22, 2019 Dr. Geraldine Walsh

Two pieces of equipment at the core of our component manufacturing process were recently replaced: the centrifuge, used to spin blood into layers of components; and the blood extractor, used to separate these layers. This was a necessary change as the old equipment was nearing end-of-life. In late Spring 2019, the process of rolling out this new equipment at sites across the country was completed, representing the culmination of several years of work by many groups at Canadian Blood Services.

Back in 2016, a Request for Proposals led to the selection of potential new equipment. Supply chain and the Centre for Innovation’s product and process development group then collaborated to test the equipment at the Centre for Innovation’s Blood4Research facility in Vancouver.

The group initially assessed how useful and effective the potential equipment would be, including its suitability to fit Canadian Blood Services’ component manufacturing processes. They then determined the best centrifuge and extractor settings to balance product quality with process efficiency. To do this, the product and process development group worked closely with supply chain to design and conduct a series of studies that tested various settings and their impact on product quality. This was a complex undertaking. Canadian Blood Services uses two different component manufacturing processes which produce several component types (including red blood cells, plasma, platelets, and cryoprecipitate plasma), and all processes and products needed to be assessed to be confident that product quality could be maintained or improved with the change in equipment.

Learn more about Canadian Blood Services component manufacturing processes here.

The equipment change was leveraged as an opportunity to improve component manufacturing processes, including efficiency and staff ergonomics. Two front-line production staff were brought to Vancouver to assess the usability and ergonomics of the equipment, and to determine the value of the equipment’s new features (e.g. automatic canula breakers). Their feedback was essential in helping choose the equipment that is now being used across the country.

Other opportunities for process improvement were also sought. For example, centrifuge inserts safeguard the whole blood collection bags while they are being centrifuged. Working with an industry partner, the product and process development group developed a more durable and easy-to-wash centrifuge insert made of silicone to replace the older inserts which were foam-based and less durable.

As part of the equipment change, the way Canadian Blood Services produce platelets from whole blood was also streamlined. Several tedious rinsing and mixing steps were eliminated. This new “One Rinse No Mix” pooling method had originally been tested by the product and process development group a few years earlier and was further assessed and adopted for implementation along with the new equipment. This improved method saves staff time and ergonomic strain.

Once the new equipment was chosen, settings and procedures were further fine-tuned to maximize the equipment’s capabilities. Confirmation studies compared the quality of products manufactured using the new equipment to historical quality control data to ensure products continued to be of the highest quality. This work drew on expertise from across the Centre for Innovation and the organization, with products tested at the Blood4Research facility in Vancouver, Centre for Innovation laboratories in Vancouver and Hamilton, and the Canadian Blood Services’ national testing laboratories in Ottawa and Brampton.

The findings from the product and process development group’s assessments provided the evidence needed to choose new equipment while maintaining confidence in the quality of the products provided to hospitals for patients. Supply chain then worked to validate the equipment, processes, and procedures in a real-world production environment, including revising or creating standard operating procedures for component processing. The evidence gathered through these efforts supported a submission to Health Canada to make a change to Canadian Blood Services’ component production procedures and processes. Health Canada approved this submission in April 2018, and the long road towards organization-wide implementation by supply chain began.

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Old foam-based centrifuge inserts (left) and longer-lasting silicon inserts (right).
Old foam-based centrifuge inserts (left) and longer-lasting silicon inserts (right).
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Whole blood unit separated into plasma, platelets, and red blood cells
A whole blood unit following centrifugation on the new equipment during equipment testing at the Vancouver Blood4Research facility.
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three units shown on left of photo) and centrifuge (on the right) in the Canadian Blood Services manufacturing site in Brampton, ON
The new blood extractors (three units shown on left of photo) and centrifuge (on the right) in the Canadian Blood Services manufacturing site in Brampton, ON. (Photo credit: Susan White)

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

 

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2018-2019 Centre for Innovation annual progress report now available


Thursday, August 15, 2019 Dr. Geraldine Walsh

Housed within Canadian Blood Services’ Medical Affairs and Innovation division, the Centre for Innovation conducts and supports research, development, and knowledge mobilization to ensure a safe, effective, and responsive blood system. This last year was another outstanding one for the Centre for Innovation – the heart of Canadian Blood Services’ research and development activities – as highlighted in the 2018-2019 annual progress report, which was recently published. 

2018-2019 highlights include: 
  • The Centre for innovation supported 124 investigators across Canada through funding and products for research programs. 
  • The Centre for Innovation’s research and innovation network published 163 peer-reviewed publications, delivered over 300 presentations at local, national, and international conferences, and wrote 26 technical reports to share with Canadian Blood Services and partners to support decision-making. 
  • Research from the Centre for Innovation informed improvements to the monocyte monolayer assay, a test that can help choose the safest blood for hard-to-match patients. These improvements helped develop the assay for use in the clinical laboratory, and it will soon “go live” in the Edmonton diagnostics laboratory.  
  • The Centre for Innovation’s product and process development group supported the introduction of a new platelet pooling set, which received Health Canada approval in 2018-2019. The new platelet pooling set is used during production of platelet components from whole blood donations and results in more consistent platelet yields. 
  • The Centre for Innovation published discovery research linking a plasma protein with platelet clotting and suggesting a new link between diet and heart health. Lead scientist, Dr. Heyu Ni, received a prestigious Canadian Institutes of Health Research Foundation Grant. 

The Centre for Innovation is proud to support Canadian Blood Services’ efforts to continuously improve products and processes and to help every patient, match every need, and serve every Canadian and is honoured to be part of “the connection between the profound discoveries of science and the joyful restoration of health.”  

Learn more about Canadian Blood Services’ mission.  

Read the 2018-2019 Centre for Innovation annual progress report in English or French.

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1.	Members of the Canadian Blood Services research network at the 2018 ISBT Congress in Toronto
Members of the Canadian Blood Services research network at the 2018 ISBT Congress in Toronto.
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2.	Training international students to perform the monocyte monolayer assay. Charlotte Paquet (France), Mairead Holton (Ireland), and Elodie Dupeuble (France) watch Selena Cen (Branch laboratory, Canadian Blood Services) perform the monocyte monolayer assay.
Training international students to perform the monocyte monolayer assay. Charlotte Paquet (France), Mairead Holton (Ireland), and Elodie Dupeuble (France) watch Selena Cen (Branch laboratory, Canadian Blood Services) perform the monocyte monolayer assay.

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Thursday, January 10, 2019
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#WeDoResearch! Through our Centre for Innovation, our engaged network of scientists, medical experts, partners, and collaborators conduct and disseminate high quality, impactful research for the benefit of Canadian patients and the Canadian healthcare system.


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This post is based on the introduction to the report written by Dr. Dana Devine, Chief Medical and Scientific Officer, and Judie Leach Bennett, Director, Centre for Innovation. Evaluating value and impact The Centre for Innovation is the organization’s hub for research, education and discovery. Our...

The ethics of doing good research


Thursday, August 08, 2019 Dr. Geraldine Walsh
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Dr. Michael McDonald sits in his office. He is wearing an Argyle sweater vest and has a white beard.
Dr. Michael McDonald, Canadian Blood Services’ Research Ethics Board Chair & Professor Emeritus at the University of British Columbia

Fostering innovation is central to Canadian Blood Services’ mission as Canada’s biological lifeline. The Canadian Blood Services Research Ethics Board (or REB) guides Canadian Blood Services researchers and those who receive research funding, data or biological material from Canadian Blood Services. The REB ensures innovation and research adhere to ethical principles and respects the rights of research participants. I learned more in conversation with REB Chair, Dr. Michael McDonald.

What is the Canadian Blood Services REB and what does it do?

The Canadian Blood Services Research Ethics Board (REB) is a multidisciplinary board established in 2001. The Canadian Blood Services REB reviews all research involving human participants conducted by or on behalf of Canadian Blood Services. This includes all research involving either personal information or biologic materials (e.g. blood, stem cells) collected by Canadian Blood Services. Without approval from the REB, a research project involving human participants cannot go ahead. The REB also advises Canadian Blood Services on bioethical issues inherent in the research reviewed. 

The REB has a responsibility to researchers, but its primary responsibility is to ensure the rights of research participants are protected.


The REB is an arm’s length committee whose decisions not to approve research protocols cannot be reversed by the Canadian Blood Services Executive Management Team or the Canadian Blood Services Board of Directors.


Who is on the Research Ethics Board?

The REB is a multidisciplinary board, currently with seven members. The Chair, Dr. McDonald, a Professor Emeritus of Applied Ethics at the University of British Columbia, has been a leader the field of Canadian research ethics. A major focus of McDonald’s research has been on the experiences of health research participants. Dr. McDonald is both an ethicist and a researcher. This dual perspective helps him balance the responsibilities of the REB to protect individuals’ rights and to foster innovation.

Other REB members include two renowned lawyers, who bring expertise in the legal aspects of research ethics and privacy, two members from the community in general (both are blood donors), and two members from the research community. All members of the REB bring their collective knowledge and expertise in ethics, privacy law, and applied research to bear on the decisions they make.

How does the REB work?

Protecting the rights of individuals

Canadian Blood Services provides researchers with unique sets of data and blood components, cord blood, and expired or discarded products from Canadian Blood Services supply chain. Canadian Blood Services cares about donors, including individuals whose data or biological material may be used for research, and is committed to protecting their rights and maintaining their trust. In Canada, anyone doing research that involves human participants must follow certain ethical guidelines, as outlined in the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans. Researchers wishing to conduct research involving human participants must submit a protocol to the REB before they begin. The REB reviews all research applications to ensure that the proposed research respects the rights and interests of research participants, and follows the the ethical principles laid down in the Tri-Council Policy Statement, and other guiding documents.

Building a bridge to researchers

The REB is a valuable resource for researchers, who may not be fully aware of all ethical concerns that might arise in the course of their research. If there are concerns, the REB raises these with the researchers. They work with researchers to ensure they understand and can address any ethical concerns and sensitivities related to the work they are proposing. 

Taking the broader view

As well as responsibilities to research participants and researchers, the REB has a responsibility to society at large. They assess research to ensure it is appropriate in that broader context, asking questions like “Will it bring value to society?”; “How will the proposed research impact affected communities?” This wider, community-focused view can often be missing in research proposals, which tend to focus instead on the details of the proposed work.

Ethics in a time of big data

Ethics is not static; it is a dynamic field, and ethical concerns and sensitivities change over time, as do the laws and requirements. The REB practices evidence-based ethics, and REB members are continuously learning to ensure they keep informed about developments in the areas of ethics, law, and research.

For example, the advent of “big data” raises interesting questions and issues for individuals (e.g.: what Facebook privacy settings are you comfortable with?) but also opportunities for research and innovation. The REB explores ethical issues around questions such as how large datasets can be used as a resource to advance the health of Canadians?

Canadian Blood Services is committed to keeping data and personal information in its custody secure and confidential. The REB review helps safeguard the security and confidentiality of any data used for research. Through the REB approval process, researchers must consider how they will manage the data, how they will meet confidentiality requirements, how the data will be secured and maintained. For a researcher, REB approval is just the beginning. The researcher must then conduct the research in an ethical manner, and safeguard any data or samples entrusted to them throughout the life cycle of the research. REB approval is an on-going process; approval is needed every year while the research is underway, and each project ends with a termination report to the REB. The termination report provides insights to the REB about project outcomes and the value brought to society.

The REB ensures research integrity – the ethics of doing good research. I’ll leave the last word to Dr. McDonald:

“Some researchers may view REB approval as a necessary if somewhat tedious hoop to jump through. But REB approval is not a pro forma process. It is a very meaningful process. Canadian Blood Services runs on trust. When Canadian Blood Services does (or facilitates) research, a bargain is entered into with research participants: whether they’ve given blood or data, Canadian Blood Services values their contribution and in return promises to use it in a meaningful and ethical way. The REB helps ensure this is the case.”

Dr. Michael McDonald
Canadian Blood Services’ Research Ethics Board Chair
Professor Emeritus at the University of British Columbia


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Communicating science is an important part of the job for anyone involved in clinical research, whether it takes place face-to-face with the patient, a donor or the wider scientific community. Unfortunately, outreach like this can seem a daunting prospect to the lab scientist and practitioner; it is often easier to hide behind the bench or the stethoscope.

Highlights from the Canadian transfusion community’s annual conference


Thursday, July 18, 2019 Dr. Geraldine Walsh

Calgary, Alberta, in the foothills of the Canadian Rockies, played host to this year’s Canadian Society for Transfusion Medicine (CSTM)/Canadian Blood Services/Héma-Québec annual conference. Canadian Blood Services is proud to be a key partner in this conference, which represents the major gathering of Canada’s transfusion medicine and science community each year. Many Centre for Innovation members attend the CSTM conference to network and exchange knowledge with colleagues across Canada. The Centre for Innovation also holds its annual Research Day in the same place and around the same time as the CSTM annual conference each year. I had the opportunity to attend both events and share my highlights here. 

Looking to the future: Centre for Innovation annual Research Day 

On May 29, the extended Canadian Blood Services research network got together to hear the latest developments and discoveries supported by the Centre for Innovation. The Centre for Innovation’s 2019 Research Day looked to the future. A series of talks described work the Centre for Innovation is conducting on “Blood Products of the Future”, which includes research to characterize cold-stored platelets – a transfusion product being explored for use in patients requiring massive transfusion – and to prepare for pathogen inactivation technologies. The “Scientists of the Future” session was an opportunity for Centre for Innovation-affiliated research trainees to give two-minute talks about their research. There were also sessions on new technologies, and advances in the areas of donor and clinical research. Dr. Paul Kubes, an invited speaker from the University of Calgary, gave an excellent talk about his research using advanced microscopy to image platelets in the body – studies that reveal fascinating details about the behaviour of these cell fragments in the body. 

Canadian Blood Services chief scientist Dr. Dana Devine led a discussion of the role of research in “Transfusion Medicine of the Future”. Touching on topics as diverse as the impact of new technologies, products and changing patient needs, to the system-wide challenges that may emerge as a result of climate change, this engaging discussion took full advantage of having a large portion of our usually dispersed research network in the same room.  

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Group photo of scientists and trainees
Centre for Innovation Research Day brought together more than 50 members of our internal and external research network.

CSTM 2019: Transfusing wisely 

The CSTM annual conference began the next day. It brings together nurses, physicians, technologists and others involved in transfusion medicine to share information, learn about the most recent developments in the field and appreciate one another’s contributions to providing effective transfusion therapy. Congratulations to all presenters from Canadian Blood Services – with 16 presentations at the conference’s workshops or oral sessions, and 39 poster presentations, Canadian Blood Services’ participation in the program was high as always.  

MSM Research 

For me, a stand-out session was “Changing Donor Management – MSM and Transgender Considerations”. In this session, some eagerly-awaited but still preliminary results from two projects funded by the MSM Research Program were presented. Mike Morrison,  an award-winning writer and entertainment and lifestyle blogger from Calgary, gave an excellent presentation in which he showed the human side of the MSM deferral policy and its impacts. 

Research highlights 

I enjoyed two sessions that highlighted the latest research being conducted by Canadian Blood Services and Héma-Québec: the “Research Highlights” session and the “Selected Oral Abstracts – Scientific” session. During these we heard about cutting edge research linking viruses and viral infectivity to clotting, new technologies that deepen understanding of blood products, including microfluidics devices to analyze red blood cells and a new type of analyzer for white blood cells. We learned about exciting research to develop monoclonal antibodies as alternative therapies that may someday replace IVIg. There were also talks about the application of research to address issues related to donor health, including iron deficiency anemia. 

A tale of two Canadas 

A final highlight was the session “Transfusion Considerations in the Indigenous Populations and Remote Locations.” This featured three presentations. Jennifer G. Daley Bernier, who has worked in Nunavut and the Northwest Territories for over a decade, described transfusion medicine challenges in Northern Canada. Ann Wilson described transfusion services in Northern Quebec. Darlene Richter and health worker Deanna Twoyoungmen provided the perspectives of Stoney First Nations towards medicine and laboratory procedures. Together these presentations highlighted the many unique challenges to the provision of medical services in northern Canada and to Indigenous people.  

While issues related to geography, weather and dispersed populations abound, it was eye-opening to learn about other perhaps less obvious issues. Communication can be a barrier. For example, there are 11 official languages in the Northwest Territories. To have a system accessible to all, hospital signage and information must be translated into all languages. Many challenges related to the effects of colonization remain. In transfusion medicine, medical histories are critical, but it can be difficult or impossible to get accurate medical histories from people who for various reasons may not have full knowledge of their medical past or who do not trust the medical system. Acknowledging cultural and socio-economic differences and adapting can help ensure everyone in Canada has access to the best care possible. 

These are a few of my highlights. The CSTM conference runs parallel sessions, so it’s impossible to cover everything! Did you attend CSTM 2019 in Calgary? Please comment below to let us know your highlights! 

 

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Button that reads We are the science behind the medicine

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Stories worth sharing: Effectively communicating “Research that matters!”


Thursday, July 04, 2019 Dr. Geraldine Walsh

Highlighting a recent blog post from Science Borealis, this “stories worth sharing” post gives background on the welcome support the Centre for Innovation’s 2018 Lay Science Writing Competition received from two key partners. 

The Centre for Blood Research (CBR) and the Centre for Innovation have a long-standing relationship. We partner regularly to deliver training and education events. The CBR helped to develop the competition and promoted it to their large network of trainees, support that helped guarantee that this inaugural competition ran smoothly and successfully.  

The Centre for Innovation also looked to Science Borealis, Canada’s leading national community of science writers and communicators, to lend their expertise as science communicators and champions of science communication in Canada. It was a pleasure to receive support from Science Borealis, and to work with Lené Gary, its general sciences editor, who supported the competition process.  

To learn more, read Gary's post about the competition, originally published on the Borealis Blog in June 2019.


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Friday, April 05, 2019
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The results of our first-ever Lay Science Writing Competition are in, read-on to discover who gets top-prize and what happens next.


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Use plain language to tell the story of your research in blood, plasma, stem cells or organs & tissues.


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Canadian Blood Services’ scientist recognized for his mentorship of graduate students


Wednesday, May 22, 2019 Dr. Geraldine Walsh

Congratulations to Canadian Blood Services' Dr. Jason Acker, who was awarded the University of Alberta Graduate Students’ Association Graduate Student Supervisor Award at a ceremony on March 22, 2019. This award recognizes "those faculty members who excel in the supervision of graduate students”. What makes this award even more special – Dr. Acker was nominated by one of his graduate students, Ruqayyah Almizraq. We chatted to Dr. Acker to learn more.

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Dr. Jason Acker
Dr. Jason Acker and Ruqayyah Almizraq at the University of Alberta Graduate Students’ Association award ceremony

 

Q: Tell us more about this award?

"I have been very fortunate to have had the opportunity to mentor and work alongside an outstanding group of graduate students over the past 17 years that I’ve been at the University. While the GSA Graduate Student Supervisor Award is intended to recognize faculty who excel in the supervision of graduate students, I think this award really recognizes the environment that we create to allow students to explore and grow as researchers. At Canadian Blood Services we have been very intentional in providing our scientists and clinicians with the resources and tools to create a supportive environment for our trainees to excel in transfusion science research. This award is a testament to our pursuit of excellence in training the next generation of transfusion scientists.”

Q: What makes this award so special for you?

“I am particularly humbled by this event as it was a student-nominated award presented by the Graduate Students’ Association which I received. To be nominated by the graduate program would have been great, but to be nominated and selected by the students is extra special!

I do not see myself as the wise man sitting on the mountain and the students as the seekers of knowledge or wisdom. I see myself as the experienced tour guide who has been fortunate to have traveled many of the back roads and trails of an interesting scientific discipline. While I may be worldly in my travels, I am not the world’s traveler and as such I do not have all of the answers nor have I come to my final destination. I enjoy traveling together with my students as I am a learner too!"


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Thursday, June 07, 2018
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Exploring barriers and enablers to more inclusive source plasma donations


Thursday, May 16, 2019 Pilar Castro

One of fifteen MSM research projects being funded by Health Canada, the Feasibility of implementing source plasma with alternative screening criteria for men who have sex with men seeks to identify barriers and enablers that will inform how Canadian Blood Services and Héma-Québec address eligibility screening criteria in the future.

Canadian Blood Services, medical director Dr. Mindy Goldman, and research project lead investigator Justin Presseau provide insight into how this project will unfold; what it means to Canada’s national blood system; and why it matters.

Plasma, which can be stored frozen for months before being sent for manufacture of plasma protein products, offers a unique avenue for undertaking the type of research that may help broaden Canada’s eligibility criteria to include groups that were unable to donate in the past.

“This research is necessary to try and identify a low risk group of MSM who could donate plasma and move away from a time-based deferral for all sexually active MSM,” explains Dr. Goldman.

For Justin Presseau - whose research program involves studying how to improve healthcare services, while seeking to understand and support altruistic behaviours or selfless acts that people undertake for the benefit and health of others - a feasibility study focused on studying barriers and enablers for men who have sex with men (MSM) to contribute, was a natural fit.

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Mindy Goldman and J Presseau

“While sexually active MSM have historically been limited from donating, the national and international conversation and research are starting to explore alternative criteria that would allow more MSM to donate by focusing on what people do, rather who they do it with, or how long it has been since they have,” explains Presseau. “And speaking personally, that is just the right thing to do. Lots of MSM have safe, low risk sex and could give back by providing life-saving plasma donations if given the opportunity to do so,” he adds.

“A lot of my work is in practice-changing research, and so I also understand that policy changes can be slower than we might like, but ultimately thanks to research evidence, the policies for MSM in Canada are moving in the right direction towards greater inclusivity,” explains Presseau. “My hope is that our research will meaningfully contribute to the move towards more inclusive policies that maintain the safety of the supply that Canadians expect,” he says.

This project involves a great many collaborators and requires active engagement with the MSM community at various intervals. In Justin Presseau’s view, meaningful, impactful research needs to be a ‘team sport’ that brings together partners with different skills, knowledge, and expertise to address complex issues.

“Throughout this study, from start to finish, we’re making community engagement an ongoing priority. I am delighted that we have assembled an engaged team of collaborators including health researchers, Canadian Blood Services, donation centre staff in London, and MSM from the community,” notes Presseau. “Building this research team was the first step and branching out beyond this core team to welcome community members onboard is the next step,” he adds.

Collaboration efforts include: open community conversations in London, Ontario, such as the Aeolian Talk on May 13, 2019 and having a presence at the annual Pride London Festival in July. Presseau is hoping that these types of discussions will lay the foundation for building trust and establishing partnerships that will span the length of the study and beyond.  “We’re currently looking for local advisory group members, who are passionate and interested in this topic—no previous research experience required,” says Presseau.  He enthusiastically encourages all who are interested to ‘get in touch’.

The project, which is just getting started in London, is expected to last two years. During this two-year period, researchers will seek to engage and document the perspectives expressed by the London MSM community, through discussions, interviews, and an online survey. “As research evidence continues to play a central role in the evolution of donor eligibility criteria in Canada, MSM should have a seat at the table in discussions on the move to more inclusive criteria,” adds Presseau.

The research team will also work closely with Canadian Blood Services donation centre staff to understand their views, training needs, and methods, as well as to ensure that any future changes to eligibility criteria can be implemented as smoothly and consistently as possible. Likewise, they intend to speak with current, repeat donors to better comprehend the practical and social aspects of donation. In the second year, they will build on what they’ve learned. Once we have analyzed what we hear from MSM, ongoing donors, and clinic staff, we will work in partnership with them to develop solutions and materials that can usefully address the barriers that have been identified,’ says Presseau.

“We have seen tremendous evolution in our policies, while maintaining the safety of the blood supply.  We realize that there is still quite a bit more work to do, but with the help of our stakeholders, we will continue to make progress,” says Dr. Goldman.

Guided by what the community feels would be most helpful, Presseau expects to develop a range of content such as videos, online resources, policy briefs, training and workshops. “Our hope is that this research will set the stage for better implementation of alternative eligibility criteria if/when policies in Canada change” adds Presseau.

Justin Presseau is a Scientist at the Ottawa Hospital Research Institute and Assistant Professor at the University of Ottawa in the School of Epidemiology and Public Health and the School of Psychology. He is also the Scientific Lead for Knowledge Translation at the Ottawa Methods Centre. He has particular expertise in implementation science research, and in the development and evaluation of healthcare improvement interventions including pilot and feasibility studies that inform larger scale randomized trials of healthcare interventions. He has particular methodological expertise in the use of rigorous methods for identifying barriers and enablers in various stakeholders (patients, members of the public, and healthcare providers) to inform the development of strategies for changing health behaviours. Dr. Presseau will ensure the methodological rigour of the research approach and oversee the conduct of the research, the analysis of findings, the budgetary expenditures and the dissemination of findings. 

Mindy Goldman is the Medical Director for Donor & Clinical Services, Medical Affairs and Innovation, Canadian Blood Services, whose group is responsible for developing donor eligibility criteria.  She has participated in the development, evaluation and implementation of criteria changes for MSM, and has expertise in regulatory requirements and international policies for blood and plasma donation.  She will develop potential alternative eligibility criteria for MSM plasma donors, in collaboration with other members of the study team, Héma-Québec, and consultations with the regulator, Health Canada.  She will ensure that study results will be as applicable as possible to Canadian Blood Services operations after conclusion of the study.


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Tuesday, January 30, 2018
Ross FitzGerald

Researchers are invited to apply for funding under the MSM Research Grant Program


Thursday, January 24, 2019
Dr. Geraldine Walsh

In this study, Dr. William Sheffield and Craig Jenkins from the Centre for Innovation tested levels and activities of important plasma factors for coagulation in recovered plasma. They found that the way in which plasma is manufactured from whole blood impacts the composition of recovered plasma.


Wednesday, November 30, 2016
Jenny Ryan

A two-day meeting will be held in January 2017 with national and international stakeholders to identify research priorities for closing knowledge gaps that impact donor eligibility for men who have sex with men.

University of Alberta’s Timothy Caulfield receives James Kreppner Award


Tuesday, May 14, 2019 Obinna Okwelume

The 2018 Canadian Blood Services’ James Kreppner Award has been awarded to Timothy Caulfield, professor and research director in the Health Law Institute at the University of Alberta.   

Valued at $50,000, the award will support Professor Caulfield’s project to analyze the marketing practices of private cord blood banks, assess their claims, and consider how regulatory tools can help ensure services marketed are done in a scientifically informed and evidence-based manner.    

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Canadian Blood Services' James Kreppner Award awarded to Timothy Caulfield

“The entire Health Law Institute team is thrilled about this award, and we truly appreciate the opportunity to dig into the complex issues associated with donation, blood products and policy development,” says Professor Caulfield. “The research seems both timely and needed. We are lucky to have an award of this nature and hope our work will reflect James Kreppner's fearless analysis of controversial issues.”  

James Kreppner was a former board member of Canadian Blood Services, a lawyer, and a strong advocate for patients’ rights and blood safety. He suffered a severe form of hemophilia-A – a genetic disorder that makes it difficult for blood to clot, and his condition often required transfusions of blood products. In 1985, he became infected with HIV and hepatitis C through tainted blood products.  

Mr. Kreppner became a key figure in establishing the public inquiry into contaminated blood and testified twice before The Krever Commission. He was also a long-time volunteer and member of the Canadian Hemophilia Society before his passing ten years ago on May 14, 2009.   

This annual award named in his honour supports one high-quality research project that explores legal and policy questions relevant to the products and services provided by Canadian Blood Services. The award’s research priorities include the legal and regulatory aspects of (a) donation, collection, storage, and use of blood, blood products, and hematopoietic stem cells; and (b) organ and tissue donation and transplantation.   

Through a series of funding programs and research collaborations, the Canadian Blood Services’ Centre for Innovation conducts and supports research in key priority areas, including projects that span the translational continuum from “bench to bedside.”  

The 2019 competition for the James Kreppner Award will open for applications in Fall 2019 and will support one project with up to $50,000 for a period of one year.   

Find out more about current and past James Kreppner Award program projects:  

Further reading:  


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration.

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Wednesday, November 09, 2016
Maeghan Toews

The James Kreppner Award program supports legal research relevant to Canadian Blood Services. Research priorities for the James Kreppner Award include the legal and regulatory aspects of (a) donation, collection, storage, and use of blood, blood products, and hematopoietic stem cells; and (b) organ and tissue donation and transplantation. The 2016 James Kreppner Award will support one project with up to $50,000 for a period of one year. This year’s competition closes Nov. 30 2016.


Wednesday, May 09, 2018
Jenny Ryan

Alana Cattapan, assistant professor in the Johnson Shoyama Graduate School of Public Policy (JSGS) at the University of Saskatchewan (U of S) has been awarded the Canadian Blood Services’ James Kreppner Award ($43,275) to study the issues related to the commercialization of blood and tissue in...

Nominations now open for the 2019 Canadian Blood Services Lifetime Achievement Award


Monday, May 13, 2019 Obinna Okwelume

Do you know someone who has made an outstanding contribution to the blood system in Canada?   

Who can be nominated?  

Recipients of the Canadian Blood Services Lifetime Achievement Award are individuals whose landmark contributions are recognized as both extraordinary and world class in the field of transfusion or transplantation medicine, stem cell or cord blood research in Canada and/or abroad. 

To be nominated for the Canadian Blood Services Lifetime Achievement Award, an individual must have contributed significantly to improving the safety and/or quality of blood, blood products, stem cells and/or cord blood or has made noteworthy improvements or advances in transfusion or transplantation medicine practice. Their record of publication should be of significance and their professional reputation should be aligned with the goals and reputation of Canadian Blood Services, reflecting a quality culture driven by excellence. 

The award will be presented on September 23, 2019 in Ottawa at the annual national Honouring Canada’s Lifeline event where we honour our donors, volunteers, peer recruiters and partners from across the country and across our products for their outstanding dedication and achievements. 

 

What's the nomination process? 

Nomination requirements 

  • Provide a short introduction and summary in 150 words or less of the nominee’s contribution to improving the safety and/or quality of blood, blood products or stem cells, or contribution to advances in transfusion medicine practice. 
  • Present a brief biography including academic, research, clinical and administrative positions, awards or recognitions. 
  • Outline how the work of the nominee is set apart from the work of others in the field. 
  • Provide a nominee’s full current curriculum vitae and contact information for the nominee including full name, mailing address, telephone number(s) and email address. 
  • Provide name and contact information for the nominator(s). 

Note: Candidates should be unaware that they have been nominated for this award. 

Submit nominations in writing to the address below:  

By mail:  

Canadian Blood Services Lifetime Achievement Award Nominating Committee 

c/o Dr. Isra Levy, Vice President, Medical Affairs and Innovation 

Canadian Blood Services 

1800 Alta Vista Drive 

Ottawa, Ontario K1G 4J5 

By email:  

isra.levy@blood.ca    

 

Submission deadline: May 30, 2019 

The nominator of the awardee, and the nominee selected, will be notified by the end of June 2019. 

 

Past honourees 

The Canadian Blood Services Lifetime Achievement Award came into existence in 2002. To date, the Canadian Blood Services Board of Directors has selected the following individuals for this prestigious award: 

• Dr. John Bowman, 2002 

• Ms. Marie Cutbush Crookston, 2002 

• Dr. Morris A. Blajchman, 2003 

• Dr. Peter Pinkerton, 2004 

• Dr. John Freedman, 2006 

• Dr. Hans Messner, 2007 

• Mr. Justice Horace Krever, 2008 

• Dr. Gail Rock, 2009 

• Dr. Victor Blanchette, 2010 

• Dr. Allen Eaves and Dr. Connie Eaves, 2011 

• Dr. Celso Bianco, 2012 

• The Canadian Hemophilia Society, 2013 

• Dr. John Dossetor, 2013 

• Dr. Gershon Growe, 2014 

• Dr. Bruce McManus, 2015 

• Dr. David Lillicrap, 2016 

• Nancy Heddle, 2017 

• André Picard, 2018 

  

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2019 Canadian Blood Services Lifetime Achievement Award

Canadian Blood Services – Driving world-class innovation 

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact.

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Related blog posts


Wednesday, January 10, 2018
Jenny Ryan

Recipients of the Canadian Blood Services Lifetime Achievement Award are individuals whose landmark contributions are recognized as both extraordinary and world class in the field of transfusion or transplantation medicine, stem cell or cord blood research in Canada and/or abroad.

Winning science research writers announced


Friday, April 05, 2019 Dr. Geraldine Walsh

To give our research trainees an opportunity to showcase their research, while honing their writing skills, Canadian Blood Services teamed-up with Science Borealis and the Centre for Blood Research, to launch our first-ever Lay Science Writing Competition.


“It’s important for researchers to be able to explain what they do in an engaging and understandable manner to those who don’t work in research. This competition is a great opportunity for trainees to hone their skills in public science communication.”

Dr. Dana Devine

Canadian Blood Services Chief Scientist


Whether it was the chance to be published or the prizes, many trainees responded to the challenge, submitting entries that reflect a breadth of research in blood, plasma, stem cells, and organs and tissues. Within the competition theme of “Research that matters”, each entry was to describe the impact of their individual or lab’s research on the transfusion and transplantation system and/or on our society. A jury of professional communicators and scientists was given the challenging task of reviewing and judging the submissions on their writing and storytelling merits, assigning a ranking and selecting the top 3 science research writers.

…and the winners of the 2019 Lay Science Writing Competition are:

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Winners Lay Science Writing Competition 2019

Our sincere congratulations to all!


“The competition provided an excellent opportunity to further develop my communication skills and expand the reach and impact of my research.”

Dr. Jennie Haw,

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Jennie Haw

1st prize winner, CIHR Health Systems Impact fellow and Canadian Blood Services researcher: Dr. Jennie Haw


Over the coming weeks, we’ll share each of the prize-winning entries on the R.E.D blog, so watch this space to learn more about these budding writers and their research.

The 2018 Canadian Blood Services Lay Science Writing Competition was organized by the Canadian Blood Services’ Centre for Innovation with welcome support from Science Borealis and the Centre for Blood Research at the University of British Columbia.


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Thursday, November 15, 2018
Jenny Ryan

Use plain language to tell the story of your research in blood, plasma, stem cells or organs & tissues.


Wednesday, December 21, 2016
Amanda Maxwell

Communicating science is an important part of the job for anyone involved in clinical research, whether it takes place face-to-face with the patient, a donor or the wider scientific community. Unfortunately, outreach like this can seem a daunting prospect to the lab scientist and practitioner; it is often easier to hide behind the bench or the stethoscope.