Stem Cells

From artificial intelligence to whale poop, and everything in between


Thursday, September 12, 2019

As Centre for Blood Research (CBR) director Dr. Edward Conway opened Research Day 2019, there was a frisson of nervous tension among the summer studentship trainees sitting in the jam-packed auditorium. These undergraduate students had spent the summer working in the laboratories of the University of British Columbia’s Centre for Blood Research (CBR) and School of Biomedical Engineering. Dr. Conway reminded them of the format for the afternoon; they would each get just 2.5 minutes to summarize their work for the audience. The squawk of a rubber chicken manned by Kevin the timekeeper would be the warning that their time was up.

And so began the rolling presentations. One after another, the students stood and presented their work on an incredibly diverse range of topics. From understanding the molecular mechanisms of breast cancer metastasis to developing microfluidic devices to analyze red blood cell deformability. From the perceived trustworthiness of artificial intelligence in medical decision-making to using social media to effectively communicate science. From 3D printing heart tissue to printing single cells using inkjet nozzles. From designing a low-cost handheld skin cancer detection device to analyzing how pumps for blood transfusions might impact the infused blood. There were thirty-five project presentations in less than two hours. But this daunting agenda delivered. Congratulations to all presenters who did a fantastic job of describing their research and keeping the audience engaged and informed.

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3.	Poster session at the CBR Research Day 2019
Poster session at the CBR Research Day 2019 (courtesy of the Centre for Blood Research)

This year for the first time, the CBR Summer Studentship Program was run in partnership with the School of Biomedical Engineering (SBME), an initiative which contributed to the diversity of topics presented. This partnership is a great fit, as noted by Dr. Conway:

“We are thrilled to have had the opportunity to welcome students from the School of Biomedical Engineering into the CBR’s Summer Studentship Program. With rapid developments in technology that contribute to the progress of medicine, constant and effective communication between biomedical engineers and life scientists is essential. I’ve had loads of feedback from this year's summer students, that they enjoyed this chance to “cross-fertilize”… we hope to expand the program!”

After the student presentations, keynote speaker Dave Ireland spoke. Ireland applies his decades of experience as a researcher and teacher to advocate for nature and the conservation of biodiversity. He has worked as a senior curator of conservation and the environment at Toronto Zoo and as the managing director of the Centre for Biodiversity at the Royal Ontario Museum. An advocate of citizen science, Ireland is also the founder of the Ontario BioBlitz, a community-based wildlife survey program that encourages public participation in science. A storyteller and communicator, Ireland asks big questions about how research can effect change in the world.

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2.	Keynote speaker, Dave Ireland, presenting at CBR Research Day 2019.
Keynote speaker Dave Ireland presenting at CBR Research Day 2019 (courtesy of the Centre for Blood Research).

By the end of Ireland’s engaging presentation, the audience had learned how whales and their poop could save the planet. Showing some impressive images of copious whale poop, Ireland described how massive phytoplankton blooms can grow around these discharges in the ocean. Whale poop is the ocean’s fertilizer. It recycles iron, an important nutrient for phytoplankton, the tiny organisms that are a major food source in marine ecologies. Like plants, phytoplankton produce oxygen and sequester carbon – linking whales and the delicate balance of the marine ecosystem directly with our planet's ability to adapt to and mitigate climate change.

CBR Research Day is the culmination of the Summer Studentship Program, and an opportunity to recognize the hard work of the summer students and all those in the laboratories who trained and supported them. After the talks, there was a poster session during which the summer students as well as graduate students and post-doctoral fellows affiliated with the CBR were given the opportunity to present their work and chat one-on-one with attendees. Prizes were given for the best poster and oral presentations, and the annual Neil Mackenzie Mentorship Excellence Award was presented.

The Centre for Innovation is proud to partner with the CBR on their Summer Studentship Program and to sponsor the CBR Research Day.

Thinking of becoming a summer student yourself?

The CBR-SMBE Summer Studentship Program provides undergraduate students with an opportunity to get hands-on lab experience. The student’s research work is guided by a principal investigator or postdoctoral fellow, and their experience is enhanced through research skills workshops, tours of campus facilities, and complementary social events.

Visit the Centre for Blood Research website for information and application details.

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1.	The summer students with CBR director, Dr. Ed Conway and keynote speaker, Dave Ireland
The summer students with CBR director, Dr. Ed Conway (far right), and keynote speaker, Dave Ireland (middle row, centre). Photo courtesy of the Centre for Blood Research.

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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2018-2019 Centre for Innovation annual progress report now available


Thursday, August 15, 2019

Housed within Canadian Blood Services’ Medical Affairs and Innovation division, the Centre for Innovation conducts and supports research, development, and knowledge mobilization to ensure a safe, effective, and responsive blood system. This last year was another outstanding one for the Centre for Innovation – the heart of Canadian Blood Services’ research and development activities – as highlighted in the 2018-2019 annual progress report, which was recently published. 

2018-2019 highlights include: 
  • The Centre for innovation supported 124 investigators across Canada through funding and products for research programs. 
  • The Centre for Innovation’s research and innovation network published 163 peer-reviewed publications, delivered over 300 presentations at local, national, and international conferences, and wrote 26 technical reports to share with Canadian Blood Services and partners to support decision-making. 
  • Research from the Centre for Innovation informed improvements to the monocyte monolayer assay, a test that can help choose the safest blood for hard-to-match patients. These improvements helped develop the assay for use in the clinical laboratory, and it will soon “go live” in the Edmonton diagnostics laboratory.  
  • The Centre for Innovation’s product and process development group supported the introduction of a new platelet pooling set, which received Health Canada approval in 2018-2019. The new platelet pooling set is used during production of platelet components from whole blood donations and results in more consistent platelet yields. 
  • The Centre for Innovation published discovery research linking a plasma protein with platelet clotting and suggesting a new link between diet and heart health. Lead scientist, Dr. Heyu Ni, received a prestigious Canadian Institutes of Health Research Foundation Grant. 

The Centre for Innovation is proud to support Canadian Blood Services’ efforts to continuously improve products and processes and to help every patient, match every need, and serve every Canadian and is honoured to be part of “the connection between the profound discoveries of science and the joyful restoration of health.”  

Learn more about Canadian Blood Services’ mission.  

Read the 2018-2019 Centre for Innovation annual progress report in English or French.

1.	Members of the Canadian Blood Services research network at the 2018 ISBT Congress in Toronto
Members of the Canadian Blood Services research network at the 2018 ISBT Congress in Toronto.
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2.	Training international students to perform the monocyte monolayer assay. Charlotte Paquet (France), Mairead Holton (Ireland), and Elodie Dupeuble (France) watch Selena Cen (Branch laboratory, Canadian Blood Services) perform the monocyte monolayer assay.
Training international students to perform the monocyte monolayer assay. Charlotte Paquet (France), Mairead Holton (Ireland), and Elodie Dupeuble (France) watch Selena Cen (Branch laboratory, Canadian Blood Services) perform the monocyte monolayer assay.

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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The ethics of doing good research


Thursday, August 08, 2019
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Dr. Michael McDonald sits in his office. He is wearing an Argyle sweater vest and has a white beard.
Dr. Michael McDonald, Canadian Blood Services’ Research Ethics Board Chair & Professor Emeritus at the University of British Columbia

Fostering innovation is central to Canadian Blood Services’ mission as Canada’s biological lifeline. The Canadian Blood Services Research Ethics Board (or REB) guides Canadian Blood Services researchers and those who receive research funding, data or biological material from Canadian Blood Services. The REB ensures innovation and research adhere to ethical principles and respects the rights of research participants. I learned more in conversation with REB Chair, Dr. Michael McDonald.

What is the Canadian Blood Services REB and what does it do?

The Canadian Blood Services Research Ethics Board (REB) is a multidisciplinary board established in 2001. The Canadian Blood Services REB reviews all research involving human participants conducted by or on behalf of Canadian Blood Services. This includes all research involving either personal information or biologic materials (e.g. blood, stem cells) collected by Canadian Blood Services. Without approval from the REB, a research project involving human participants cannot go ahead. The REB also advises Canadian Blood Services on bioethical issues inherent in the research reviewed. 

The REB has a responsibility to researchers, but its primary responsibility is to ensure the rights of research participants are protected.


The REB is an arm’s length committee whose decisions not to approve research protocols cannot be reversed by the Canadian Blood Services Executive Management Team or the Canadian Blood Services Board of Directors.


Who is on the Research Ethics Board?

The REB is a multidisciplinary board, currently with seven members. The Chair, Dr. McDonald, a Professor Emeritus of Applied Ethics at the University of British Columbia, has been a leader the field of Canadian research ethics. A major focus of McDonald’s research has been on the experiences of health research participants. Dr. McDonald is both an ethicist and a researcher. This dual perspective helps him balance the responsibilities of the REB to protect individuals’ rights and to foster innovation.

Other REB members include two renowned lawyers, who bring expertise in the legal aspects of research ethics and privacy, two members from the community in general (both are blood donors), and two members from the research community. All members of the REB bring their collective knowledge and expertise in ethics, privacy law, and applied research to bear on the decisions they make.

How does the REB work?

Protecting the rights of individuals

Canadian Blood Services provides researchers with unique sets of data and blood components, cord blood, and expired or discarded products from Canadian Blood Services supply chain. Canadian Blood Services cares about donors, including individuals whose data or biological material may be used for research, and is committed to protecting their rights and maintaining their trust. In Canada, anyone doing research that involves human participants must follow certain ethical guidelines, as outlined in the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans. Researchers wishing to conduct research involving human participants must submit a protocol to the REB before they begin. The REB reviews all research applications to ensure that the proposed research respects the rights and interests of research participants, and follows the the ethical principles laid down in the Tri-Council Policy Statement, and other guiding documents.

Building a bridge to researchers

The REB is a valuable resource for researchers, who may not be fully aware of all ethical concerns that might arise in the course of their research. If there are concerns, the REB raises these with the researchers. They work with researchers to ensure they understand and can address any ethical concerns and sensitivities related to the work they are proposing. 

Taking the broader view

As well as responsibilities to research participants and researchers, the REB has a responsibility to society at large. They assess research to ensure it is appropriate in that broader context, asking questions like “Will it bring value to society?”; “How will the proposed research impact affected communities?” This wider, community-focused view can often be missing in research proposals, which tend to focus instead on the details of the proposed work.

Ethics in a time of big data

Ethics is not static; it is a dynamic field, and ethical concerns and sensitivities change over time, as do the laws and requirements. The REB practices evidence-based ethics, and REB members are continuously learning to ensure they keep informed about developments in the areas of ethics, law, and research.

For example, the advent of “big data” raises interesting questions and issues for individuals (e.g.: what Facebook privacy settings are you comfortable with?) but also opportunities for research and innovation. The REB explores ethical issues around questions such as how large datasets can be used as a resource to advance the health of Canadians?

Canadian Blood Services is committed to keeping data and personal information in its custody secure and confidential. The REB review helps safeguard the security and confidentiality of any data used for research. Through the REB approval process, researchers must consider how they will manage the data, how they will meet confidentiality requirements, how the data will be secured and maintained. For a researcher, REB approval is just the beginning. The researcher must then conduct the research in an ethical manner, and safeguard any data or samples entrusted to them throughout the life cycle of the research. REB approval is an on-going process; approval is needed every year while the research is underway, and each project ends with a termination report to the REB. The termination report provides insights to the REB about project outcomes and the value brought to society.

The REB ensures research integrity – the ethics of doing good research. I’ll leave the last word to Dr. McDonald:

“Some researchers may view REB approval as a necessary if somewhat tedious hoop to jump through. But REB approval is not a pro forma process. It is a very meaningful process. Canadian Blood Services runs on trust. When Canadian Blood Services does (or facilitates) research, a bargain is entered into with research participants: whether they’ve given blood or data, Canadian Blood Services values their contribution and in return promises to use it in a meaningful and ethical way. The REB helps ensure this is the case.”

Dr. Michael McDonald
Canadian Blood Services’ Research Ethics Board Chair
Professor Emeritus at the University of British Columbia


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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I’m fascinated by the power of stem cells: Q&A with Dr. Nicolas Pineault


Friday, July 19, 2019

For more than two decades, Dr. Nicolas Pineault has worked in stem cell biology. Since joining Canadian Blood Services in 2012 as a development scientist at the Centre for Innovation, he has conducted research in stem cells from cord blood, bone marrow cells and platelets. Dr. Pineault is an adjunct professor at the University of Ottawa (uOttawa).  

Because July is Cord Blood Awareness Month, we talked to Dr. Pineault about his ongoing research in cord blood, as well as his passions and other new projects. 


Q. Tell us about yourself and the work you’re currently engaged in. 

A. I've been working in the field of stem cell biology since my PhD studies, which I did at the University of British Columbia from 1995-2001. Before joining Canadian Blood Services in 2012, I was a research scientist in the research and development division at Héma-Québec. My other passions in life are hockey, sports, camping and spending time with my family.  

At Canadian Blood Services, I oversee two areas of development and research. First, together with my senior research assistant Roya Pasha, I support the operation of the stem cell manufacturing branch of the organization, including the public cord blood bank located here in Ottawa. We also provide technical and knowledge support. For instance, we developed a thaw protocol for cord blood units distributed by Canadian Blood Services, and optimized various processes used in the stem cell manufacturing business.  

My second area of research is studying the impact that stem cell expansion has on the capacity of cord blood stem cells to support engraftment. This research occurs here in our lab at head office and at the animal facility of uOttawa, and is mainly conducted by the graduate students, honour students and post-doctoral fellows whom I supervise and support. 

Q. What are the biggest challenges that currently exist in cord blood research?  

A. Two areas of work are very popular in the field of cord blood hematopoietic research. The first area is improving the engraftment activity of cord blood to lead to faster recovery of transplant patients. This is done either by tricking stem cells to move to the bone more efficiently after transplant, or by expanding stem cells so that more cells are available for transplantation. Our lab does a lot of research in these areas. Another exciting area of work is gene editing, which could one day provide a long-term cure for patients with common hemoglobinopathies such as sickle cell anemia and beta-thalassemia. This approach tries to genetically correct point-mutations in the DNA of the patients’ stem cells so that their progeny-like red cells can produce normal red cells.  

Q. How do you see the role of your research in improving outcomes for Canadian patients?  

A. Stem cell transplantation is used to cure over 80 diseases, including leukemia and immunodeficiencies, and new exciting possibilities are emerging that may cure other diseases or disorders such as autism and cerebral palsy. So, our work focuses on maximising the quality of stem cell products processed and produced at the Canadian Blood Services to improve outcomes of stem cell transplant for Canadian patients.   

Q. What’s your next project? 

A. We're currently working on a project for the stem cell manufacturing lab in Ottawa about donor-lymphocyte infusion, or DLI products. The objective of this project is to demonstrate that the DLI product retains its quality attributes following changes in production requested by The Ottawa Hospital, namely freezing smaller volumes in new bags. In my wish list, I would love to bring in and optimize the technology that can be used to correct sickle-cell mutation in hematopoietic stem cells. This disease is one of the most common genetic disorders in humans, and current treatment options are not curative. 

Q. Why do you care about your work? 

A. I never thought as an undergrad student in biochemistry at Laval University that I would one day work in the field of stem cell biology. This changed after I did my first immunology course and spent a summer internship at the R&D department of the Red Cross in Quebec City. Since then, I have always been fascinated and impressed by the power of stem cells, and by the incredible research that surrounds these special cells. This is one of the passions that fuels my energy for my line of work. 

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Dr Nicolas Pineault wears a lab coat and holds a blue plastic container in a stem cell lab
Dr. Nicolas Pineault

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Highlights from the Canadian transfusion community’s annual conference


Thursday, July 18, 2019

Calgary, Alberta, in the foothills of the Canadian Rockies, played host to this year’s Canadian Society for Transfusion Medicine (CSTM)/Canadian Blood Services/Héma-Québec annual conference. Canadian Blood Services is proud to be a key partner in this conference, which represents the major gathering of Canada’s transfusion medicine and science community each year. Many Centre for Innovation members attend the CSTM conference to network and exchange knowledge with colleagues across Canada. The Centre for Innovation also holds its annual Research Day in the same place and around the same time as the CSTM annual conference each year. I had the opportunity to attend both events and share my highlights here. 

Looking to the future: Centre for Innovation annual Research Day 

On May 29, the extended Canadian Blood Services research network got together to hear the latest developments and discoveries supported by the Centre for Innovation. The Centre for Innovation’s 2019 Research Day looked to the future. A series of talks described work the Centre for Innovation is conducting on “Blood Products of the Future”, which includes research to characterize cold-stored platelets – a transfusion product being explored for use in patients requiring massive transfusion – and to prepare for pathogen inactivation technologies. The “Scientists of the Future” session was an opportunity for Centre for Innovation-affiliated research trainees to give two-minute talks about their research. There were also sessions on new technologies, and advances in the areas of donor and clinical research. Dr. Paul Kubes, an invited speaker from the University of Calgary, gave an excellent talk about his research using advanced microscopy to image platelets in the body – studies that reveal fascinating details about the behaviour of these cell fragments in the body. 

Canadian Blood Services chief scientist Dr. Dana Devine led a discussion of the role of research in “Transfusion Medicine of the Future”. Touching on topics as diverse as the impact of new technologies, products and changing patient needs, to the system-wide challenges that may emerge as a result of climate change, this engaging discussion took full advantage of having a large portion of our usually dispersed research network in the same room.  

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Group photo of scientists and trainees
Centre for Innovation Research Day brought together more than 50 members of our internal and external research network.

CSTM 2019: Transfusing wisely 

The CSTM annual conference began the next day. It brings together nurses, physicians, technologists and others involved in transfusion medicine to share information, learn about the most recent developments in the field and appreciate one another’s contributions to providing effective transfusion therapy. Congratulations to all presenters from Canadian Blood Services – with 16 presentations at the conference’s workshops or oral sessions, and 39 poster presentations, Canadian Blood Services’ participation in the program was high as always.  

MSM Research 

For me, a stand-out session was “Changing Donor Management – MSM and Transgender Considerations”. In this session, some eagerly-awaited but still preliminary results from two projects funded by the MSM Research Program were presented. Mike Morrison,  an award-winning writer and entertainment and lifestyle blogger from Calgary, gave an excellent presentation in which he showed the human side of the MSM deferral policy and its impacts. 

Research highlights 

I enjoyed two sessions that highlighted the latest research being conducted by Canadian Blood Services and Héma-Québec: the “Research Highlights” session and the “Selected Oral Abstracts – Scientific” session. During these we heard about cutting edge research linking viruses and viral infectivity to clotting, new technologies that deepen understanding of blood products, including microfluidics devices to analyze red blood cells and a new type of analyzer for white blood cells. We learned about exciting research to develop monoclonal antibodies as alternative therapies that may someday replace IVIg. There were also talks about the application of research to address issues related to donor health, including iron deficiency anemia. 

A tale of two Canadas 

A final highlight was the session “Transfusion Considerations in the Indigenous Populations and Remote Locations.” This featured three presentations. Jennifer G. Daley Bernier, who has worked in Nunavut and the Northwest Territories for over a decade, described transfusion medicine challenges in Northern Canada. Ann Wilson described transfusion services in Northern Quebec. Darlene Richter and health worker Deanna Twoyoungmen provided the perspectives of Stoney First Nations towards medicine and laboratory procedures. Together these presentations highlighted the many unique challenges to the provision of medical services in northern Canada and to Indigenous people.  

While issues related to geography, weather and dispersed populations abound, it was eye-opening to learn about other perhaps less obvious issues. Communication can be a barrier. For example, there are 11 official languages in the Northwest Territories. To have a system accessible to all, hospital signage and information must be translated into all languages. Many challenges related to the effects of colonization remain. In transfusion medicine, medical histories are critical, but it can be difficult or impossible to get accurate medical histories from people who for various reasons may not have full knowledge of their medical past or who do not trust the medical system. Acknowledging cultural and socio-economic differences and adapting can help ensure everyone in Canada has access to the best care possible. 

These are a few of my highlights. The CSTM conference runs parallel sessions, so it’s impossible to cover everything! Did you attend CSTM 2019 in Calgary? Please comment below to let us know your highlights! 

 

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Button that reads We are the science behind the medicine

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Cord blood for research – what you need to know


Tuesday, July 09, 2019

 

July is Cord Blood Awareness Month. Stay tuned for more posts about cord blood and how it helps patients, both through treatment and through research. 


To meet a recognized need for a centralized program providing ethnically sourced cord blood for research projects in Canada, Canadian Blood Services, in partnership with The Ottawa Hospital, launched the Cord Blood for Research Program in 2014. Here's what you need to know: 

Why is there a need for cord blood research? 

On any given day, hundreds of Canadians are in need of an unrelated stem cell donor. Cord blood is a rich source of blood forming stem cells and can be used in the treatment of more than 80 diseases and disorders such as leukemia, lymphoma, and aplastic anemia.  

The Cord Blood for Research Program facilitates research that could lead to new discoveries and improvements in patient care. Providing access to cord blood for research is essential to increase our knowledge about current processes for collecting, manufacturing and storing cord blood, and to improve cord blood transplantation outcomes. 

Stem cells from cord blood are also being investigated in the development of new treatments for many diseases, providing hope for more safe and effective medical therapies in the future. Other biomedical research unrelated to stem cells may also use cord blood, and lead to new discoveries that may improve medical care in the future. 

How do we source the cord blood used for research?  

Not all cord blood units are suitable for banking. In fact, the Canadian Blood Services Cord Blood Bank discards some of its cord blood collections, primarily due to insufficient volume, low number of total nucleated cells or low number of stem cells contained in the collected cord blood.  

With mothers’ consent, collected cord blood products that do not meet the criteria for storage in the Cord Blood Bank are distributed by the program to approved research projects, reducing the waste of this precious resource. This happens in partnership with our collection sites in Brampton, Edmonton, Ottawa, and Vancouver. Women who deliver at any of these sites are given the option to consent to donate their baby’s cord blood for biomedical research. 

What are some of the recent research areas?  

The Cord Blood for Research Program is a conduit to promote advances in the fields of transfusion, cellular therapy, and transplantation medicine. In the last fiscal year, the program distributed 155 cord blood units for research. Some recent projects supported with cord blood products from the program include:  

  • An automated manufacturing solution for expansion of blood stem cells 

  • Cell-based therapy for experimental acute kidney injury 

  • Hematopoietic stem cells and transfusion medicine 

  • Regulatory T cells from discarded human thymus for adoptive cell immunotherapy: moving garbage to gold 

  • Stem Cells of the musculoskeletal system: An epigenetics study from childhood to adulthood 

  • Study of immuno-therapeutics anti-tumor efficacy in humanized mice 

Our research network works to share findings from this widely to encourage the application of the knowledge created through the program.  


During Cord Blood Awareness Month, make some time to learn more about why cord blood matters and our Cord Blood for Research Program.  You can also watch this video about donating cord blood.

To donate, visit blood.ca/donatecord

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Nathaly, a mother who donated cord blood, holds her baby and toddler.
Nathaly, a cord blood donor, with Knox and Navi.

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Stories worth sharing: Effectively communicating “Research that matters!”


Thursday, July 04, 2019

Highlighting a recent blog post from Science Borealis, this “stories worth sharing” post gives background on the welcome support the Centre for Innovation’s 2018 Lay Science Writing Competition received from two key partners. 

The Centre for Blood Research (CBR) and the Centre for Innovation have a long-standing relationship. We partner regularly to deliver training and education events. The CBR helped to develop the competition and promoted it to their large network of trainees, support that helped guarantee that this inaugural competition ran smoothly and successfully.  

The Centre for Innovation also looked to Science Borealis, Canada’s leading national community of science writers and communicators, to lend their expertise as science communicators and champions of science communication in Canada. It was a pleasure to receive support from Science Borealis, and to work with Lené Gary, its general sciences editor, who supported the competition process.  

To learn more, read Gary's post about the competition, originally published on the Borealis Blog in June 2019.


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Canadian Blood Services’ scientist recognized for his mentorship of graduate students


Wednesday, May 22, 2019

Congratulations to Canadian Blood Services' Dr. Jason Acker, who was awarded the University of Alberta Graduate Students’ Association Graduate Student Supervisor Award at a ceremony on March 22, 2019. This award recognizes "those faculty members who excel in the supervision of graduate students”. What makes this award even more special – Dr. Acker was nominated by one of his graduate students, Ruqayyah Almizraq. We chatted to Dr. Acker to learn more.

Dr. Jason Acker
Dr. Jason Acker and Ruqayyah Almizraq at the University of Alberta Graduate Students’ Association award ceremony

 

Q: Tell us more about this award?

"I have been very fortunate to have had the opportunity to mentor and work alongside an outstanding group of graduate students over the past 17 years that I’ve been at the University. While the GSA Graduate Student Supervisor Award is intended to recognize faculty who excel in the supervision of graduate students, I think this award really recognizes the environment that we create to allow students to explore and grow as researchers. At Canadian Blood Services we have been very intentional in providing our scientists and clinicians with the resources and tools to create a supportive environment for our trainees to excel in transfusion science research. This award is a testament to our pursuit of excellence in training the next generation of transfusion scientists.”

Q: What makes this award so special for you?

“I am particularly humbled by this event as it was a student-nominated award presented by the Graduate Students’ Association which I received. To be nominated by the graduate program would have been great, but to be nominated and selected by the students is extra special!

I do not see myself as the wise man sitting on the mountain and the students as the seekers of knowledge or wisdom. I see myself as the experienced tour guide who has been fortunate to have traveled many of the back roads and trails of an interesting scientific discipline. While I may be worldly in my travels, I am not the world’s traveler and as such I do not have all of the answers nor have I come to my final destination. I enjoy traveling together with my students as I am a learner too!"


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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University of Alberta’s Timothy Caulfield receives James Kreppner Award


Tuesday, May 14, 2019

The 2018 Canadian Blood Services’ James Kreppner Award has been awarded to Timothy Caulfield, professor and research director in the Health Law Institute at the University of Alberta.   

Valued at $50,000, the award will support Professor Caulfield’s project to analyze the marketing practices of private cord blood banks, assess their claims, and consider how regulatory tools can help ensure services marketed are done in a scientifically informed and evidence-based manner.    

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Canadian Blood Services' James Kreppner Award awarded to Timothy Caulfield

“The entire Health Law Institute team is thrilled about this award, and we truly appreciate the opportunity to dig into the complex issues associated with donation, blood products and policy development,” says Professor Caulfield. “The research seems both timely and needed. We are lucky to have an award of this nature and hope our work will reflect James Kreppner's fearless analysis of controversial issues.”  

James Kreppner was a former board member of Canadian Blood Services, a lawyer, and a strong advocate for patients’ rights and blood safety. He suffered a severe form of hemophilia-A – a genetic disorder that makes it difficult for blood to clot, and his condition often required transfusions of blood products. In 1985, he became infected with HIV and hepatitis C through tainted blood products.  

Mr. Kreppner became a key figure in establishing the public inquiry into contaminated blood and testified twice before The Krever Commission. He was also a long-time volunteer and member of the Canadian Hemophilia Society before his passing ten years ago on May 14, 2009.   

This annual award named in his honour supports one high-quality research project that explores legal and policy questions relevant to the products and services provided by Canadian Blood Services. The award’s research priorities include the legal and regulatory aspects of (a) donation, collection, storage, and use of blood, blood products, and hematopoietic stem cells; and (b) organ and tissue donation and transplantation.   

Through a series of funding programs and research collaborations, the Canadian Blood Services’ Centre for Innovation conducts and supports research in key priority areas, including projects that span the translational continuum from “bench to bedside.”  

The 2019 competition for the James Kreppner Award will open for applications in Fall 2019 and will support one project with up to $50,000 for a period of one year.   

Find out more about current and past James Kreppner Award program projects:  

Further reading:  


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration.

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Nominations now open for the 2019 Canadian Blood Services Lifetime Achievement Award


Monday, May 13, 2019

Do you know someone who has made an outstanding contribution to the blood system in Canada?   

Who can be nominated?  

Recipients of the Canadian Blood Services Lifetime Achievement Award are individuals whose landmark contributions are recognized as both extraordinary and world class in the field of transfusion or transplantation medicine, stem cell or cord blood research in Canada and/or abroad. 

To be nominated for the Canadian Blood Services Lifetime Achievement Award, an individual must have contributed significantly to improving the safety and/or quality of blood, blood products, stem cells and/or cord blood or has made noteworthy improvements or advances in transfusion or transplantation medicine practice. Their record of publication should be of significance and their professional reputation should be aligned with the goals and reputation of Canadian Blood Services, reflecting a quality culture driven by excellence. 

The award will be presented on September 23, 2019 in Ottawa at the annual national Honouring Canada’s Lifeline event where we honour our donors, volunteers, peer recruiters and partners from across the country and across our products for their outstanding dedication and achievements. 

 

What's the nomination process? 

Nomination requirements 

  • Provide a short introduction and summary in 150 words or less of the nominee’s contribution to improving the safety and/or quality of blood, blood products or stem cells, or contribution to advances in transfusion medicine practice. 
  • Present a brief biography including academic, research, clinical and administrative positions, awards or recognitions. 
  • Outline how the work of the nominee is set apart from the work of others in the field. 
  • Provide a nominee’s full current curriculum vitae and contact information for the nominee including full name, mailing address, telephone number(s) and email address. 
  • Provide name and contact information for the nominator(s). 

Note: Candidates should be unaware that they have been nominated for this award. 

Submit nominations in writing to the address below:  

By mail:  

Canadian Blood Services Lifetime Achievement Award Nominating Committee 

c/o Dr. Isra Levy, Vice President, Medical Affairs and Innovation 

Canadian Blood Services 

1800 Alta Vista Drive 

Ottawa, Ontario K1G 4J5 

By email:  

isra.levy@blood.ca    

 

Submission deadline: May 30, 2019 

The nominator of the awardee, and the nominee selected, will be notified by the end of June 2019. 

 

Past honourees 

The Canadian Blood Services Lifetime Achievement Award came into existence in 2002. To date, the Canadian Blood Services Board of Directors has selected the following individuals for this prestigious award: 

• Dr. John Bowman, 2002 

• Ms. Marie Cutbush Crookston, 2002 

• Dr. Morris A. Blajchman, 2003 

• Dr. Peter Pinkerton, 2004 

• Dr. John Freedman, 2006 

• Dr. Hans Messner, 2007 

• Mr. Justice Horace Krever, 2008 

• Dr. Gail Rock, 2009 

• Dr. Victor Blanchette, 2010 

• Dr. Allen Eaves and Dr. Connie Eaves, 2011 

• Dr. Celso Bianco, 2012 

• The Canadian Hemophilia Society, 2013 

• Dr. John Dossetor, 2013 

• Dr. Gershon Growe, 2014 

• Dr. Bruce McManus, 2015 

• Dr. David Lillicrap, 2016 

• Nancy Heddle, 2017 

• André Picard, 2018 

  

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2019 Canadian Blood Services Lifetime Achievement Award

Canadian Blood Services – Driving world-class innovation 

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact.

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