Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Erythrocyte saturation with IgG is required for inducing antibody-mediated immune suppression and impacts both erythrocyte clearance and antigen-modulation mechanisms Cruz-Leal Y, Marjoram D, Lazarus AH 2018 J Immunol View Researchers Basic research
Extracellular vesicle characteristics in stored red blood cell concentrates are influenced by the method of detection Almizraq RJ, Seghatchian J, Holovati JL, Acker JP 2017 Transfus Apher Sci View Researchers Basic research
Gender and BCR-ABL transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia Lin HX, Sjaarda J, Dyck J, Stringer R, Hillis C, Harvey M, Carter R, Ainsworth P, Leber B, Pare G, Sadikovic B 2016 Eur J Haematol View Researchers Clinical research
Mesenchymal stromal cells from patients with acute myeloid leukemia have altered capacity to expand differentiated hematopoietic progenitors Chandran P, Le Y, Li Y, Sabloff M, Mehic J, Rosu-Myles M, Allan DS 2015 Leuk Res View Researchers Basic research
Physical Activity and Natural Anti-VIP Antibodies: Potential Role in Breast and Prostate Cancer Therapy Veljkovic M, Dopsaj V, Dopsaj M, Branch DR, Veljkovic N, Sakarellos-Daitsiotis MM, Veljkovic V, Glisic S, Colombatti A 2011 PLoS One View Researchers Basic research
Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis Hou Y, Carrim N, Wang Y, Gallant RC, Marshall A, Ni H 2015 J Biomed Res View Researchers Basic research
Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain Kurbegovic A, Trudel M 2013 Hum Mol Genet View Researchers Basic research
Red blood cell processing methods and in-hospital mortality: a transfusion registry cohort study Heddle NM, Arnold DM, Acker JP, Liu Y, Barty RL, Eikelboom JW, Webert KE, Hsia CC, O'Brien SF, Cook RJ 2016 Lancet Haematol View Researchers Clinical research
Subunit-directed click coupling via doubly cross-linked hemoglobin efficiently produces readily purified functional bis-tetrameric oxygen carriers Singh S, Dubinsky-Davidchik IS, Yang Y, Kluger R 2015 Org Biomol Chem View Researchers Basic research
The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody–mediated amelioration of murine immune thrombocytopenia Crow AR, Suppa SJ, Chen X, Mott PJ, Lazarus AH 2011 Blood View Researchers Basic research
Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution Kwan DH, Constantinescu I, Chapanian R, Higgins MA, Kotzler MP, Samain E, Boraston AB, Kizhakkedathu JN, Withers SG 2015 J Am Chem Soc View Researchers New or improved product or process
Unraveling the IVIG mystique Branch DR 2013 Transfusion View Researchers Other
Psychometric properties of the Patient Reported Outcomes, Burdens and Experiences (PROBE) questionnaire Chai-Adisaksopha C, Skinner MW, Curtis R, Frick N, Nichol MB, Noone D, O'Mahony B, Page D, Stonebraker J, Thabane L, Crowther M, Iorio A 2018 BMJ Open View Researchers Clinical research
Antiplatelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia Guo L, Kapur R, Aslam R, Hunt K, Hou Y, Zufferey A, Speck ER, Rondina MT, Lazarus AH, Ni H, Semple JW 2018 Scand J Immunol View Researchers Basic research
Biocompatibility and toxicity of novel iron chelator Starch-Deferoxamine (S-DFO) compared to zinc oxide nanoparticles to zebrafish embryo: An oxidative stress based apoptosis, physicochemical and neurological study profile Nasrallah GK, Salem R, Da'as S, Al-Jamal OLA, Scott M, Mustafa I 2019 Neurotoxicol Teratol View Researchers Basic research
Modelling the Need for New Blood Donors Following a Change in Deferral Period Blake J 2019 Industrial Engineering and Operations Management View Researchers New or improved product or process
The use of IVIg in fetal and neonatal alloimmune thrombocytopenia— Principles and mechanisms Wabnitz H, Khan R, Lazarus AH 2020 Transfus Apher Sci View Researchers Clinical research
Blood donation and the global COVID-19 pandemic: areas for social science research Haw J, Holloway K, Masser B, Merz E-M, Thrope R 2020 Vox Sang View Researchers New or improved product or process
Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Fc Receptor-Targeting Biologics Lewis BJB, Branch DR 2020 Pharmacology View Researchers Basic research
Quality of evidence-based guidelines for platelet transfusion and use: A systematic review Al-Riyami AZ, Jug R, La Rocca U, Keshavarz H, Landry D, Shehata N, Stanworth SJ, Nahirniak S 2021 Transfusion View Researchers Benchmarking and standard setting
Themed issue – focusing on donor assessment, motivation and vigilance O’Brien SF, Ullum H, Seed CR 2021 Vox Sang View Researchers New or improved product or process
Factor product utilization and health outcomes in patients with haemophilia A and B on extended half-life concentrates: A Canadian observational study of real-world outcomes Sun H, Yang M, Poon M-C, Lee A, Robinson KS, Sholzberg M, Wu J, Iorio A, Blanchette V, Carcao M, Klaassen RJ, Jackson S 2021 Haemophilia View Researchers Clinical research
Challenging the 30-min rule for thawed plasma Ramirez-Arcos S, Howell A, Bearne J, Bhakta V, Bower L, Cardigan R, Girard M, Kou Y, McDonald C, Nolin M-È, Sawicka D, Sheffield W 2021 Vox Sang View Researchers Benchmarking and standard setting
How do I think about blood donor eligibility criteria for medical conditions? Goldman M 2021 Transfusion View Researchers Benchmarking and standard setting
A scalable serology solution for profiling humoral immune responses to SARS-CoV-2 infection and vaccination Colwill K, Galipeau Y, Stuible M, Gervais C, Arnold C, Rathod B, Abe KT, Wang JH, Pasculescu A, Maltseva M, Rocheleau L, Pelchat M, Fazel-Zarandi M, Iskilova M, Barrios-Rodiles M, Bennett L, Yau K, Cholette F, Mesa C, Li AX, Paterson A, Hladunewich MA, Goodwin PJ, Wrana JL, Drews SJ, Mubareka S, McGeer AJ, Kim J, Langlois M-A, Gingras A-C, Durocher Y 2022 medRxiv View Researchers New or improved product or process
ResearchUnit: A proposed mechanism for vaccine-induced thrombotic thrombocytopenia Batarfi K 2021 Blood.ca website View Researchers Clinical research
The Effect of Sex-Mismatched Red Blood Cell Transfusion on Endothelial Cell Activation in Critically Ill Patients Alshalani A, van Manen L, Boshuizen M, van Bruggen R, Acker JP, Juffermans NP 2022 Transfus Med Hemother View Researchers Clinical research
A thermoreversible poly(choline phosphate) based universal biomembrane adhesive Yu X, Yang X, Horte S, Kizhakkedathu JN, Brooks DE 2014 Macromol Biosci View Researchers Basic research
Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice Liu J, Santhanakrishnan M, Natarajan P, Gibb DR, Eisenbarth SC, Tormey CA, Siddon AJ, Stowell SR, Branch DR, Hendrickson JE 2016 Blood View Researchers Basic research
Bacterial survival and distribution during buffy coat platelet production Taha M, Kalab M, Yi QL, Maurer E, Jenkins C, Schubert P, Ramirez-Arcos S 2016 Vox Sang View Researchers New or improved product or process
Chloride and other electrolyte concentrations in commonly available 5% albumin products Lai AT, Zeller MP, Millen T, Kavsak P, Szczeklik W, Elahie A, Alhazzani W, D'Aragon F, Jaeschke R, Lamontagne F, Karachi T, Cook D, Meade M, Rochwerg B 2018 Crit Care Med View Researchers Clinical research
Concentré de recherche: La présence de résidus de plasma favorise l'adhérence des bactéries à la paroi des poches utilisées pour les concentrés de plaquettes Ramirez-Arcos S 2017 Blood.ca website View Researchers Basic research
Design of long circulating nontoxic dendritic polymers for the removal of iron in vivo Imran ul-haq M, Hamilton JL, Lai BF, Shenoi RA, Horte S, Constantinescu I, Leitch HA, Kizhakkedathu JN 2013 ACS Nano View Researchers Basic research
Does intravenous contrast-enhanced computed tomography cause acute kidney injury? Protocol of a systematic review of the evidence Kayibanda JF, Hiremath S, Knoll GA, Fergusson D, Chow BJ, Shabana W, Akbari A 2014 Syst Rev View Researchers Clinical research
Efficacy of HLA-matched platelet transfusions for patients with hypoproliferative thrombocytopenia: a systematic review Pavenski K, Rebulla P, Duquesnoy R, Saw CL, Slichter SJ, Tanael S, Shehata N, International Collaboration for Guideline Development Implementation and Evaluation for Transfusion Therapies (ICTMG) Collaborators 2013 Transfusion View Researchers Clinical research
In silico analysis suggests interaction between Ebola virus and the extracellular matrix Veljkovic V, Glisic S, Muller CP, Scotch M, Branch DR, Perovic VR, Sencanski M, Veljkovic N, Colombatti A 2015 Front Microbiol View Researchers Basic research
Low-intensity pulsed ultrasound-mediated stimulation of hematopoietic stem/progenitor cell viability, proliferation and differentiation in vitro Xu P, Gul-Uludag H, Ang WT, Yang X, Huang M, Marquez-Curtis L, McGann L, Janowska-Wieczorek A, Xing J, Swanson E, Chen J 2012 Biotechnol Lett View Researchers Basic research
Microscope-based label-free microfluidic cytometry Su X, Kirkwood SE, Gupta M, Marquez-Curtis L, Qiu Y, Janowska-Wieczorek A, Rozmus W, Tsui YY 2011 Opt Express View Researchers New or improved product or process
N-ethylmaleimide activates a Cl(-)-independent component of K(+) flux in mouse erythrocytes Shmukler BE, Hsu A, Alves J, Trudel M, Rust MB, Hubner CA, Rivera A, Alper SL 2013 Blood Cells Mol Dis View Researchers Basic research
Quality and Safety of Blood Products Ramirez-Arcos S, Marks DC, Acker JP, Sheffield WP 2016 J Blood Transfus View Researchers Other
Riboflavin and ultraviolet light treatment potentiates vasodilator-stimulated phosphoprotein Ser-239 phosphorylation in platelet concentrates during storage Schubert P, Culibrk B, Coupland D, Scammell K, Gyongyossy-Issa M, Devine DV 2012 Transfusion View Researchers Basic research
The efficacy and safety of topical tranexamic acid: A systematic review and meta-analysis Montroy J, Hutton B, Moodley P, Fergusson NA, Cheng W, Tinmouth A, Lavallee LT, Fergusson DA, Breau RH 2018 Transfus Med Rev View Researchers Clinical research
The promise of organ and tissue preservation to transform medicine Giwa S, Lewis JK, Alvarez L, Langer R, Roth AE, Church GM, Markmann JF, Sachs DH, Chandraker A, Wertheim JA, Rothblatt M, Boyden E, Eidbo E, Lee A, Pomahac B, Brandacher, Weinstock D, Elliott G, Nelson D, Acker JP, Uygun K, Schmalz B, Weegman B, Tocchio A, Fahy GM 2017 Nat Biotechnol View Researchers New or improved product or process
The transcription factor Miz-1 is required for embryonic and stress-induced erythropoiesis but dispensable for adult erythropoiesis Kosan C, Rashkovan M, Ross J, Schaffer AM, Saba I, Lemsaddek W, Trudel M, Moroy T 2014 Am J Blood Res View Researchers Basic research
Transfusion requirements in cardiac surgery III (TRICS III): study design of a randomized controlled trial Shehata N, Whitlock R, Fergusson DA, Thorpe KE, MacAdams C, Grocott HP, Rubens F, Fremes S, Lellouche F, Bagshaw S, Royse A, Rosseel PM, Hare G, Medicis E, Hudson C, Belley-Cote E, Bainbridge D, Kent B, Shaw A, Byrne K, Syed S, Royse CF, McGuiness S, Hall J, Mazer CD 2018 J Cardiothorac Vasc Anesth View Researchers Clinical research
Antimicrobial peptides: an effective approach to prevent bacterial biofilm formation in platelet concentrates Alabdullatif M, Atreya CD, Ramirez-Arcos S 2018 Transfusion View Researchers New or improved product or process
Biological mechanisms implicated in adverse outcomes of sex mismatched transfusions Alshalani A, Li W, Juffermans NP, Seghatchian J, Acker JP 2019 Transfus Apher Sci View Researchers Basic research
Improved in vitro quality of stored red blood cells upon oxygen reduction prior to riboflavin/UV light treatment of whole blood Schubert P, Culibrk B, Chen D, Serrano K, Levin E, Chen Z, Zoescher P, Goodrich RP, Yoshida T, Devine DV 2019 Transfusion View Researchers New or improved product or process
Pertussis vaccine effectiveness in a frequency matched population-based case-control Canadian Immunization Research Network study in Ontario, Canada 2009–2015 Crowcroft NS, Schwartz KL, Chen C, Johnson C, Li Y, Marchand-Austin A, Bolotin S, Jamieson FB, Drews SJ, Russell ML, Svenson LW, Simmonds K, Mahmud SM, Kwong JC 2019 Vaccine View Researchers Clinical research
ABO blood group and COVID-19: a review on behalf of the ISBT COVID-19 working group Goel R, Bloch EM, Pirenne F, Al-Riyami AZ, Crowe E, Dau L, Land K, Townsend M, Jecko T, Rahimi-Levene N, Patidar G, Josephson CD, Arora S, Vermeulen M, Vrielink H, Montemayor C, Oreh A, Hindawi S, van den Berg K, Serrano K, So – Osman C, Wood E, Devine DV, Spitalnik SL, the ISBT COVID-19 Working Group 2021 Vox Sang View Researchers Clinical research