Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets Zufferey A, Speck ER, Machlus KR, Aslam R, Guo L, McVey MJ, Kim M, Kapur R, Boilard E, Italiano JE, Jr., Semple JW 2017 Blood Adv View Researchers Basic research
Non-invasive spectroscopy of transfusable red blood cells stored inside sealed plastic blood-bags Buckley K, Atkins CG, Chen D, Schulze HG, Devine DV, Blades MW, Turner RFB 2016 Analyst View Researchers New or improved product or process
Platelet MicroRNAs: An Overview Dahiya N, Sarachana T, Vu L, Becker KG, Wood WH, Zhang Y, Atreya CD 2015 Transfus Med Rev View Researchers Basic research
Preserving and using germplasm and dissociated embryonic cells for conserving Caribbean and Pacific coral Hagedorn M, Carter V, Martorana K, Paresa MK, Acker J, Baums IB, Borneman E, Brittsan M, Byers M, Henley M, Laterveer M, Leong JA, McCarthy M, Meyers S, Nelson BD, Petersen D, Tiersch T, Uribe RC, Woods E, Wildt D 2012 PLoS One View Researchers Basic research
The immune-stimulation capacity of liposome-treated red blood cells da Silveira Cavalcante L, Branch DR, Duong TT, Yeung RSM, Acker JP, Holovati JL 2017 J Liposome Res View Researchers Basic research
Utility of cross-matched platelet transfusions in patients with hypoproliferative thrombocytopenia: a systematic review Vassallo RR, Fung M, Rebulla P, Duquesnoy R, Saw CL, Slichter SJ, Tanael S, Shehata N, International Collaboration for Guideline Development Implementation Evaluation for Transfusion Therapies Collaborators 2013 Transfusion View Researchers Clinical research
Anti-M Clarke G, Cote J, Lane D 2018 Blood.ca website View Researchers Basic research
ResearchUnit: Modeling risk to ensure safety when considering changes to blood testing O'Brien S 2019 Blood.ca website View Researchers Basic research
Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage Wan H, Wang Y, Ai J, Brathwaite S, Ni H, Macdonald RL, Hol EM, Meijers JCM, Vergouwen MDI 2018 J Thromb Haemost View Researchers Basic research
The association between platelet transfusions and mortality in patients with critical illness Ning S, Liu Y, Barty R, Cook R, Rochwerg B, Iorio A, Warkentin TE, Heddle NM, Arnold DM 2019 Transfusion View Researchers Clinical research
The impact of red blood cell manufacturing variables on bacterial growth dynamics: a pilot study Ramirez-Arcos S, Kou Y, Cayer M-P, De Grandmont M-J, Girard M, Cloutier M 2019 Vox Sang View Researchers Basic research
Overcoming the deceptively low viability of CD45+ cells in thawed cord blood unit segments Pasha R, Halpenny M, Pineault N 2019 Vox Sang View Researchers New or improved product or process
Anti-inflammatory activity of CD44 antibodies in murine immune thrombocytopenia is mediated by Fc? receptor inhibition Norris PAA, Kaur G, Khan R, Zhu G, Ni H, Lazarus AH 2021 Blood View Researchers Basic research
Daudi cell stroma: An alternative to dithiothreitol to resolve daratumumab interference in pretransfusion testing Tremblay T, Branch DR, Loubaki L 2020 Transfusion View Researchers New or improved product or process
Selection and in vitro and in vivo characterization of a Kunitz protease inhibitor domain of protease nexin 2 variant that inhibits factor XIa without inhibiting plasmin Eltringham-Smith LJ, Bhakta V, Sheffield WP 2021 J Biotechnol View Researchers Basic research
Five novel FY null alleles associated with typing discrepancies Vege S, Floch A, Lomas-Frances C, Clarke G, Westhoff CM 2021 Transfusion View Researchers Benchmarking and standard setting
Background incidence rates of hospitalisations and emergency department visits for thromboembolic and coagulation disorders in Ontario, Canada for COVID-19 vaccine safety assessment: a population-based retrospective observational study Nasreen S, Calzavara AJ, Sundaram ME, MacDonald SE, Righolt CH, Pai M, Field TS, Zhou LW, Wilson SE, Kwong JC 2021 BMJ Open View Researchers Clinical research
Plateletworks® as a Point-of-Care Test for ASA Non-Sensitivity Khan H, Jain S, Gallant RC, Syed MH, Zamzam A, Al-Omran M, Rand ML, Ni H, Abdin R, Qadura M 2021 J Pers Med View Researchers New or improved product or process
Sexual issues in people with haemophilia: Awareness and strategies for overcoming communication barriers Blamey G, Van Tassel B, Sagermann E, Stain AM, Waterhouse L, Iorio A 2022 Haemophilia View Researchers Ethical, legal and social implications research
Taking lessons from nature to improve cell therapy cryopreservation Acker J, William N, Coatham M 2023 Cell Gene Ther Insights View Researchers Basic research
Molecular Screening of Blood Donors for Babesia in Tyrol, Austria Bloch EM, Siller A, Tonnetti L, Drews SJ, Spencer BR, Hedges D, Mergenthal T, Weber-Schehl M, Astl M, Patel EU, Gaber M, Schennach H 2023 Transfus Med Hemother View Researchers Clinical research
Characteristics of VITT antibodies in patients vaccinated with Ad26.COV2.S Huynh A, Arnold DM, Michael JV, Clare R, Smith JW, Daka M, Ianosi-Irimie M, McKenzie SE, Kelton JG, Nazy I 2023 Blood Adv View Researchers Clinical research
Donor sex, pre-donation hemoglobin, and manufacturing affect CD71+ cells in red cell concentrates Li W, William N, Acker JP 2023 Transfusion View Researchers Basic research
How do we decide how representative our donors are for public health surveillance? O'Brien SF, Drews SJ, Lewin A, Russell A, Davison K, Goldman M, International Society for Blood Transfusion Transfusion Transmitted Infectious Disease Working Party Surveillance Risk Assessment Policy Sub-group 2022 Transfusion View Researchers Benchmarking and standard setting
GRADE guidance 35: update on rating imprecision for assessing contextualized certainty of evidence and making decisions Schünemann HJ, Neumann I, Hultcrantz M, Brignardello-Petersen R, Zeng L, Murad MH, Izcovich A, Morgano GP, Baldeh T, Santesso N, Cuello CG, Mbuagbaw L, Guyatt G, Wiercioch W, Piggott T, De Beer H, Vinceti M, Mathioudakis AG, Mayer MG, Mustafa R, Filippini T, Iorio A, Nieuwlaat R, Marcucci M, Coello PA, Bonovas S, Piovani D, Tomlinson G, Akl EA 2022 J Clin Epidemiol View Researchers Clinical research
Cold-stored platelets are effective in an in vitro model of massive transfusion protocol assessed by rotational thromboelastometry Zhao HQ, Serrano K, Culibrk B, Chen Z, Devine DV 2022 Transfusion View Researchers New or improved product or process
[Influence of Anticoagulants on Detection of ITP Platelet-Specific Autoantibodies and Relationship of Autoantibody Types with Glucocorticoid Efficacy] Chen Y, Ge J, Ruan M, Zhu L-Y, Zeng Q-S, Xia R-X, Ni H 2015 Zhongguo shi yan xue ye xue za zhi View Researchers Basic research
A platelet cover-up Arnold DM 2013 Blood View Researchers Other
Adoptive-Transfer Effects of Intravenous Immunoglobulin in Autoimmunity Lazarus AH 2010 J Clin Immunol View Researchers Basic research
Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis Lei X, Reheman A, Hou Y, Zhou H, Wang Y, Marshall AH, Liang C, Dai X, Li BX, Vanhoorelbeke K, Ni H 2014 Thromb Haemost View Researchers Basic research
Comparative efficacy of blood cell immunocamouflage by membrane grafting of methoxypoly(ethylene glycol) and polyethyloxazoline Kyluik-Price DL, Li L, Scott MD 2014 Biomaterials View Researchers Basic research
Decreased indoleamine 2,3-dioxygenase expression in dendritic cells and role of indoleamine 2,3-dioxygenase-expressing dendritic cells in immune thrombocytopenia Xu SQ, Wang CY, Zhu XJ, Dong XY, Shi Y, Peng J, Qin P, Sun JZ, Guo C, Ni H, Hou M 2012 Ann Hematol View Researchers Basic research
Effect of Blood Donor Characteristics on Transfusion Outcomes: A Systematic Review and Meta-Analysis Chasse M, McIntyre L, English SW, Tinmouth A, Knoll G, Wolfe D, Wilson K, Shehata N, Forster A, van Walraven C, Fergusson DA 2016 Transfus Med Rev View Researchers Clinical research
Eryptosis in health and disease: A paradigm shift towards understanding the (patho)physiological implications of programmed cell death of erythrocytes Qadri SM, Bissinger R, Solh Z, Oldenborg PA 2017 Blood Rev View Researchers Basic research
Extracellular matrix proteins in the regulation of thrombus formation Wang Y, Gallant RC, Ni H 2016 Curr Opin Hematol View Researchers Basic research
Fusion to human serum albumin extends the circulatory half-life and duration of antithrombotic action of the Kunitz protease inhibitor domain of Protease Nexin 2 Sheffield WP, Eltringham-Smith LJ, Bhakta V 2018 Cell Physiol Biochem View Researchers Basic research
Impact of osteoblast maturation on their paracrine growth enhancing activity on cord blood progenitors Alsheikh M, Abu?Khader A, Michalicka M, Pasha R, Pineault N 2017 Eur J Haematol View Researchers Basic research
Mesenchymal stromal cells derived from various tissues: Biological, clinical and cryopreservation aspects Marquez-Curtis LA, Janowska-Wieczorek A, McGann LE, Elliott JAW 2015 Cryobiology View Researchers Other
Optimal conditions for the performance of a monocyte monolayer assay Tong TN, Burke-Murphy E, Sakac D, Pendergrast J, Cserti-Gazdewich C, Laroche V, Branch DR 2016 Transfusion View Researchers Basic research
Phospholipidomics reveals differences in glycerophosphoserine profiles of hypothermically stored red blood cells and microvesicles Bicalho B, Holovati JL, Acker JP 2013 Biochim Biophys Acta View Researchers Basic research
Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond Xu XR, Zhang D, Oswald BE, Carrim N, Wang X, Hou Y, Zhang Q, Lavalle C, McKeown T, Marshall AH, Ni H 2016 Crit Rev Clin Lab Sci View Researchers Basic research
Progress in RNAi-mediated Molecular Therapy of Acute and Chronic Myeloid Leukemia Landry B, Valencia-Serna J, Gul-Uludag H, Jiang X, Janowska-Wieczorek A, Brandwein J, Uludag H 2015 Mol Ther Nucleic Acids View Researchers Other
Red blood cell membrane water permeability increases with length of ex vivo storage Alshalani A, Acker JP 2017 Cryobiology View Researchers Basic research
Residual risk of bacterial contamination of platelets: six years of experience with sterility testing Ramirez-Arcos S, DiFranco C, McIntyre T, Goldman M 2017 Transfusion View Researchers New or improved product or process
Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa Donkor DA, Bhakta V, Eltringham-Smith LJ, Stafford AR, Weitz JI, Sheffield WP 2017 Sci Rep View Researchers Basic research
The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand Boyle AJ, Roddick LA, Bhakta V, Lambourne MD, Junop MS, Liaw PC, Weitz JI, Sheffield WP 2013 BMC Biochem View Researchers Basic research
The mechanism and modulation of complement activation on polymer grafted cells Leung VL, Kizhakkedathu JN 2016 Acta Biomater View Researchers Basic research
Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway Krisinger MJ, Goebeler V, Lu Z, Meixner SC, Myles T, Pryzdial EL, Conway EM 2012 Blood View Researchers Basic research
Virus-Platelet Associations Pryzdial ELG, Lin BH, Sutherland MR 2017 Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update View Researchers Basic research
Serpin Phage Display: The Use of a T7 System to Probe Reactive Center Loop Libraries with Different Serine Proteinases de Souza LR, Scott BM, Bhakta V, Donkor DA, Perruzza DL, Sheffield WP 2018 Serpins: Methods and Protocols View Researchers Other