Our Research Publications
Updated November 2023
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Title | Authors | Year | Journal | Link to Article | Intended Audience Sort descending | Purpose |
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New insights into IVIg mechanisms and alternatives in autoimmune and inflammatory diseases | Norris PAA, Kaur G, Lazarus AH | 2020 | Curr Opin Hematol | View New insights into IVIg mechanisms and alternatives in autoimmune and inflammatory diseases | Researchers | Basic research |
The timing of gamma irradiation and its effect on cell-free and microvesicle-bound hemoglobin. The BEST collaborative study | William N, Bicahlo B, Hansen A, de Korte D, Acker JP, Biomedical Excellence for Safer Transfusion Collaborative | 2022 | Transfusion | View The timing of gamma irradiation and its effect on cell-free and microvesicle-bound hemoglobin. The BEST collaborative study | Researchers | Basic research |
Necrotizing enterocolitis and mortality after transfusion of ABO non-identical blood | Parvizian MK, Barty R, Heddle NM, Li N, McDougall T, Mukerji A, Fusch C, Solh Z | 2021 | Transfusion | View Necrotizing enterocolitis and mortality after transfusion of ABO non-identical blood | Researchers | Clinical research |
Mechanism of increased efficacy of recombinant Fc-?TP-L309C compared to IVIg to ameliorate mouse immune thrombocytopenia | Lewis BJB, Binnington B, Blacquiere M, Spirig R, Käsermann F, Branch DR | 2021 | eJHaem | View Mechanism of increased efficacy of recombinant Fc-?TP-L309C compared to IVIg to ameliorate mouse immune thrombocytopenia | Researchers | Basic research |
The SSC platelet immunology register of VITT and VIITP: Toward standardization of laboratory and clinical parameters | Choi PY, Grace RF, Therese Ahlen M, Nazy I, Sachs UJ, Arnold DM, McKenzie SE, Althaus K, Sharma R, Bakchoul T | 2021 | J Thromb Haemost | View The SSC platelet immunology register of VITT and VIITP: Toward standardization of laboratory and clinical parameters | Researchers | Benchmarking and standard setting |
Determining the Optimal SARS-CoV-2 mRNA Vaccine Dosing Interval for Maximum Immunogenicity | Asamoah-Boaheng M, Goldfarb D, Prusinkiewicz MA, Golding L, Karim ME, Barakauskas V, Wall N, Jassem AN, Marquez AC, MacDonald C, O'Brien SF, Lavoie P, Grunau B | 2023 | Cureus | View Determining the Optimal SARS-CoV-2 mRNA Vaccine Dosing Interval for Maximum Immunogenicity | Researchers | Clinical research |
Staphylococcal Enterotoxins Enhance Biofilm Formation by Staphylococcus aureus in Platelet Concentrates | Chi SI, Ramirez-Arcos S | 2023 | Microorganisms | View Staphylococcal Enterotoxins Enhance Biofilm Formation by Staphylococcus aureus in Platelet Concentrates | Researchers | Basic research |
‘A Most Equitable Drug’: How the Clinical Studies of Convalescent Plasma as a Treatment for SARS-CoV-2 Might Usefully Inform Post-Pandemic Public Sector Approaches to Drug Development | Grundy Q, Campbell C, Ali R, Herder M, Holloway K | 2023 | J Law Med Ethics | View ‘A Most Equitable Drug’: How the Clinical Studies of Convalescent Plasma as a Treatment for SARS-CoV-2 Might Usefully Inform Post-Pandemic Public Sector Approaches to Drug Development | Researchers | Ethical, legal & social implications research |
Clinical and laboratory predictors of fetal and neonatal alloimmune thrombocytopenia | Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM | 2022 | Transfusion | View Clinical and laboratory predictors of fetal and neonatal alloimmune thrombocytopenia | Researchers | Clinical research |
Severe fetal anemia caused by anti-Jra: Burst forming unit-erythroid colony formation inhibition assay suggesting possible erythroid suppression mechanism | Tran A, Yan MTS, Branch DR, Blacquiere M, Pineault N, Pasha R, Clarke G | 2023 | Transfusion | View Severe fetal anemia caused by anti-Jra: Burst forming unit-erythroid colony formation inhibition assay suggesting possible erythroid suppression mechanism | Researchers | Clinical research |
A novel VSV/HIV pseudotype approach for the study of HIV microbicides without requirement for level 3 biocontainment | Harrison AL, Henry S, Mahfoud R, Manis A, Albertini A, Gaudin Y, Lingwood CA, Branch DR | 2011 | Future Virol | View A novel VSV/HIV pseudotype approach for the study of HIV microbicides without requirement for level 3 biocontainment | Researchers | Basic research |
Cell-based therapy using umbilical cord blood for novel indications in regenerative therapy and immune modulation: an updated systematic scoping review of the literature | Rizk M, Aziz J, Shorr R, Allan DS | 2017 | Biol Blood Marrow Transplant | View Cell-based therapy using umbilical cord blood for novel indications in regenerative therapy and immune modulation: an updated systematic scoping review of the literature | Researchers | Clinical research |
Combination of 4Ts score and PF4/H-PaGIA for diagnosis and management of heparin-induced thrombocytopenia: prospective cohort study | Linkins LA, Bates SM, Lee AY, Heddle NM, Wang G, Warkentin TE | 2015 | Blood | View Combination of 4Ts score and PF4/H-PaGIA for diagnosis and management of heparin-induced thrombocytopenia: prospective cohort study | Researchers | Clinical research |
Early gamma-irradiation and subsequent storage of red cells in SAG?M additive solution potentiate energy imbalance, microvesiculation and susceptibility to stress?induced apoptotic cell death | Qadri S, Chen D, Schubert P, Devine D, Sheffield W | 2017 | Vox Sang | View Early gamma-irradiation and subsequent storage of red cells in SAG?M additive solution potentiate energy imbalance, microvesiculation and susceptibility to stress?induced apoptotic cell death | Researchers | Basic research |
Expression screening of bacterial libraries of recombinant alpha-1 proteinase inhibitor variants for candidates with thrombin inhibitory capacity | Bhakta V, Gierczak RF, Sheffield WP | 2013 | J Biotechnol | View Expression screening of bacterial libraries of recombinant alpha-1 proteinase inhibitor variants for candidates with thrombin inhibitory capacity | Researchers | Basic research |
How do I interpret a confidence interval? | O'Brien SF, Yi QL | 2016 | Transfusion | View How do I interpret a confidence interval? | Researchers | Other |
Innate immunity as orchestrator of bone marrow homing for hematopoietic stem/progenitor cells | Ratajczak MZ, Kim C, Ratajczak J, Janowska-Wieczorek A | 2013 | Complement Therapeutics | View Innate immunity as orchestrator of bone marrow homing for hematopoietic stem/progenitor cells | Researchers | Basic research |
Large scale studies assessing anti-factor VIII antibody development in previously untreated haemophilia A: what has been learned, what to believe and how to learn more | Iorio A, Fischer K, Makris M | 2017 | Br J Haematol | View Large scale studies assessing anti-factor VIII antibody development in previously untreated haemophilia A: what has been learned, what to believe and how to learn more | Researchers | Clinical research |
Medium conditioned with mesenchymal stromal cell-derived osteoblasts improves the expansion and engraftment properties of cord blood progenitors | Dumont N, Boyer L, Emond H, Saltik BC, Pasha R, Bazin R, Mantovani D, Roy DC, Pineault N | 2014 | Exp Hematol | View Medium conditioned with mesenchymal stromal cell-derived osteoblasts improves the expansion and engraftment properties of cord blood progenitors | Researchers | Basic research |
Peripheral blood monocyte-derived chemokine blockade prevents murine antibody-mediated transfusion-related acute lung injury (TRALI) | McKenzie CG, Kim M, Singh TK, Milev Y, Freedman J, Semple JW | 2014 | Blood | View Peripheral blood monocyte-derived chemokine blockade prevents murine antibody-mediated transfusion-related acute lung injury (TRALI) | Researchers | Basic research |
Rationale and Design of the Informing Fresh versus Old Red Cell Management (INFORM) Trial: An International Pragmatic Randomized Trial | Eikelboom JW, Cook RJ, Barty R, Liu Y, Arnold DM, Crowther MA, Devereaux PJ, Ellis M, Figueroa P, Gallus A, Hirsh J, Kurz A, Roxby D, Sessler DI, Sharon Y, Sobieraj-Teague M, Warkentin TE, Webert KE, Heddle NM | 2016 | Transfus Med Rev | View Rationale and Design of the Informing Fresh versus Old Red Cell Management (INFORM) Trial: An International Pragmatic Randomized Trial | Researchers | Clinical research |
Storage of red blood cells affects membrane composition, microvesiculation, and in vitro quality | Almizraq R, Tchir JD, Holovati JL, Acker JP | 2013 | Transfusion | View Storage of red blood cells affects membrane composition, microvesiculation, and in vitro quality | Researchers | Basic research |
The M358R variant of α1-proteinase inhibitor inhibits coagulation factor VIIa | Sheffield WP, Bhakta V | 2016 | Biochem Biophys Res Commun | View The M358R variant of α1-proteinase inhibitor inhibits coagulation factor VIIa | Researchers | Basic research |
Therapeutic cells via functional modification: Influence of molecular properties of polymer grafts on in vivo circulation, clearance, immunogenicity and antigen protection | Chapanian R, Constantinescu I, Medvedev N, Scott MD, Brooks DE | 2013 | Biomacromolecules | View Therapeutic cells via functional modification: Influence of molecular properties of polymer grafts on in vivo circulation, clearance, immunogenicity and antigen protection | Researchers | Basic research |
Managing antithrombotic therapy in immune thrombocytopenia: development of the TH2 risk assessment score | Balitsky AK, Kelton JG, Arnold DM | 2018 | Blood | View Managing antithrombotic therapy in immune thrombocytopenia: development of the TH2 risk assessment score | Researchers | New or improved product or process |
The first case of severe acute hemolytic transfusion reaction caused by anti-Sc2 | Lemay A-S, Tong TN, Branch DR, Huang M, Sumner C, Oldfield L, Hawes J, Cserti-Gazdewich CM, Lau W | 2018 | Transfusion | View The first case of severe acute hemolytic transfusion reaction caused by anti-Sc2 | Researchers | Clinical research |
Low-molecular-weight heparin venous thromboprophylaxis in critically ill patients with renal dysfunction: A subgroup analysis of the PROTECT trial | Pai M, Adhikari NKJ, Ostermann M, Heels-Ansdell D, Douketis JD, Skrobik Y, Qushmaq I, Meade M, Guyatt G, Geerts W, Walsh MW, Crowther MA, Friedrich JO, Burry L, Bellomo R, Brandao da Silva N, Costa Filho R, Cox MJ, Alves Silva S, Cook DJ, on behalf of the PROTECT Investigators | 2018 | PLoS One | View Low-molecular-weight heparin venous thromboprophylaxis in critically ill patients with renal dysfunction: A subgroup analysis of the PROTECT trial | Researchers | Clinical research |
Ultraviolet-based pathogen inactivation systems: untangling the molecular targets activated in platelets | Schubert P, Johnson L, Marks DC, Devine DV | 2018 | Front Med | View Ultraviolet-based pathogen inactivation systems: untangling the molecular targets activated in platelets | Researchers | Basic research |
Intravenous immunoglobulin (IVIg) or IVIg-treated macrophages reduce DSS-induced colitis by inducing macrophage IL-10 production | Kozicky LK, Menzies SC, Hotte N, Madsen KL, Sly LM | 2019 | Eur J Immunol | View Intravenous immunoglobulin (IVIg) or IVIg-treated macrophages reduce DSS-induced colitis by inducing macrophage IL-10 production | Researchers | Basic research |
Platelet rich plasma in treatment of musculoskeletal pathologies | Mehrabani D, Seghatchian J, Acker JP | 2019 | Transfus Apher Sci | View Platelet rich plasma in treatment of musculoskeletal pathologies | Researchers | Basic research |
Aging, chronic inflammation, and platelet hyperactivity | Ma W, Karakas D, Chen ZY, Ni H | 2020 | Ann Blood | View Aging, chronic inflammation, and platelet hyperactivity | Researchers | Basic research |
A crosswalk tabular review on methods and outcomes from randomized clinical trials using pathogen reduced platelets | Rebulla P, Garban F, van der Meer PF, Heddle NM, McCullough J | 2020 | Transfusion | View A crosswalk tabular review on methods and outcomes from randomized clinical trials using pathogen reduced platelets | Researchers | Clinical research |
Update on newer approaches to prevent or treat COVID-19 infection: What we all need the most right now!! | Seghatchian J, Acker JP, Putter JS | 2020 | Transfus Apher Sci | View Update on newer approaches to prevent or treat COVID-19 infection: What we all need the most right now!! | Researchers | New or improved product or process |
Terminal half-life of FVIII and FIX according to age, blood group and concentrate type: Data from the WAPPS database | Versloot O, Iserman E, Chelle P, Germini F, Edginton AN, Schutgens REG, Iorio A, Fischer K | 2021 | J Thromb Haemost | View Terminal half-life of FVIII and FIX according to age, blood group and concentrate type: Data from the WAPPS database | Researchers | Clinical research |
Antibody and cellular therapies for treatment of covid-19: a living systematic review and network meta-analysis | Siemieniuk RA, Bartoszko JJ, Díaz Martinez JP, Kum E, Qasim A, Zeraatkar D, Izcovich A, Mangala S, Ge L, Han MA, Agoritsas T, Arnold D, Ávila C, Chu DK, Couban R, Cusano E, Darzi AJ, Devji T, Foroutan F, Ghadimi M, Khamis A, Lamontagne F, Loeb M, Miroshnychenko A, Motaghi S, Murthy S, Mustafa RA, Rada G, Rochwerg B, Switzer C, Vandvik PO, Vernooij RW, Wang Y, Yao L, Guyatt GH, Brignardello-Petersen R | 2021 | BMJ | View Antibody and cellular therapies for treatment of covid-19: a living systematic review and network meta-analysis | Researchers | Clinical research |
Hemolysis after high-dose intravenous immunoglobulin: An under-appreciated sequelae | Branch DR, Almizraq RJ, Bussel JB | 2022 | Am J Hematol | View Hemolysis after high-dose intravenous immunoglobulin: An under-appreciated sequelae | Researchers | Basic research |
Prolonged Blood Storage and Risk of Posttransfusion Acute Kidney Injury | Adegboye J, Sapatnekar S, Mascha EJ, Shah K, Lioudis M, Essber H, Cohen B, Rivas E, Heddle NM, Eikelboom JW, Ellis MH, Sharon Y, Sinha R, Kurz A, Sessler DI | 2022 | Anesthesiology | View Prolonged Blood Storage and Risk of Posttransfusion Acute Kidney Injury | Researchers | Clinical research |
A critical contribution in a time of crisis: Examining motivations and deterrents to COVID-19 convalescent plasma donation and future donation intentions among prospective Canadian donors | Holloway K, Campbell C, Ali R, Huyer LD, Hart D, Haw J, Brennenstuhl S, Grundy Q | 2022 | Transfus Med | View A critical contribution in a time of crisis: Examining motivations and deterrents to COVID-19 convalescent plasma donation and future donation intentions among prospective Canadian donors | Researchers | Ethical, legal & social implications research |
Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude | Li M, Tang X, Liao Z, Shen C, Cheng R, Fang M, Wang G, Li Y, Tang S, Xie L, Zhang Z, Kamau PM, Mwangi J, Lu Q, Li Y, Wang Y, MacKeigan DT, Cerenzia EG, Ni H, Lai R | 2022 | Blood | View Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude | Researchers | Basic research |
RE: A better normal in Canada will need a better detection system for emerging and re-emerging respiratory pathogens | O'Brien S, Goldman M, Drews S | 2022 | CMAJ | View RE: A better normal in Canada will need a better detection system for emerging and re-emerging respiratory pathogens | Researchers | Clinical research |
Clinical Outcomes of Umbilical Cord Blood Transplantation Using Ex Vivo Expansion: A Systematic Review and Meta-Analysis of Controlled Studies | Saiyin T, Kirkham AM, Bailey AJM, Shorr R, Pineault N, Maganti HB, Allan DS | 2023 | Transplant Cell Ther | View Clinical Outcomes of Umbilical Cord Blood Transplantation Using Ex Vivo Expansion: A Systematic Review and Meta-Analysis of Controlled Studies | Researchers | Clinical research |
Contamination of platelet concentrates with Staphylococcus aureus induces significant modulations in platelet functionality | Yousuf B, Pasha R, Pineault N, Ramirez-Arcos S | 2022 | Vox Sang | View Contamination of platelet concentrates with Staphylococcus aureus induces significant modulations in platelet functionality | Researchers | Basic research |
A bioinformatics approach to identify natural autoantibodies from healthy blood donors' sera reactive with the HCV NS5A-derived peptide by immunoassay | Vasiljevic N, Veljkovic N, Kosec T, Ma XZ, Glisic S, Prljic J, Vujicic AD, Markovic L, Branch DR | 2011 | Viral Immunol | View A bioinformatics approach to identify natural autoantibodies from healthy blood donors' sera reactive with the HCV NS5A-derived peptide by immunoassay | Researchers | Basic research |
A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial | Ypma PF, van der Meer PF, Heddle NM, van Hilten JA, Stijnen T, Middelburg RA, Hervig T, van der Bom JG, Brand A, Kerkhoffs JL | 2016 | BMJ Open | View A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial | Researchers | Clinical research |
Antibody binding to megakaryocytes in vivo in patients with immune thrombocytopenia | Arnold DM, Nazi I, Toltl LJ, Ross C, Ivetic N, Smith JW, Liu Y, Kelton JG | 2015 | Eur J Haematol | View Antibody binding to megakaryocytes in vivo in patients with immune thrombocytopenia | Researchers | Clinical research |
Blood donors implicated in transfusion-related acute lung injury with patient-specific HLA antibodies are more broadly sensitized to HLA antigens compared to other blood donors | Saw CL, Hannach B, Petrazsko T, Nickerson P | 2013 | Transfusion | View Blood donors implicated in transfusion-related acute lung injury with patient-specific HLA antibodies are more broadly sensitized to HLA antigens compared to other blood donors | Researchers | Clinical research |
Characterization of a long-acting recombinant human serum albumin-atrial natriuretic factor (ANF) expressed in Pichia pastoris | de Bold MK, Sheffield WP, Martinuk A, Bhakta V, Eltringham-Smith L, de Bold AJ | 2012 | Regul Pept | View Characterization of a long-acting recombinant human serum albumin-atrial natriuretic factor (ANF) expressed in Pichia pastoris | Researchers | Basic research |
Complement C1q enhances homing-related responses of hematopoietic stem/progenitor cells | Jalili A, Marquez-Curtis L, Shirvaikar N, Wysoczynski M, Ratajczak M, Janowska-Wieczorek A | 2010 | Transfusion | View Complement C1q enhances homing-related responses of hematopoietic stem/progenitor cells | Researchers | Basic research |
Dengue virus binding and replication by platelets | Simon AY, Sutherland MR, Pryzdial ELG | 2015 | Blood | View Dengue virus binding and replication by platelets | Researchers | Basic research |
Distribution, origin and contamination risk of coagulase-negative staphylococci from platelet concentrates | Rood IGH, de Korte D, RamÃrez-Arcos S, Savelkoul PHM, Pettersson A | 2011 | J Med Microbiol | View Distribution, origin and contamination risk of coagulase-negative staphylococci from platelet concentrates | Researchers | Basic research |