Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Proposal of a two-step process for the diagnosis of sepsis-induced disseminated intravascular coagulation Iba T, Levy JH, Yamakawa K, Thachil J, Warkentin TE, Levi M, Scientific and Standardization Committee on DIC of the International Society on Thrombosis and Haemostasis 2019 J Thromb Haemost View Researchers New or improved product or process
Targeting ABL1 or ARG Tyrosine Kinases to Restrict HIV-1 Infection in Primary CD4+ T?Cells or in Humanized NSG Mice McCarthy SDS, Leontyev D, Nicoletti P, Binnington B, Kozlowski HN, Ostrowski M, Cochrane A, Branch DR, Wong RW 2019 J Acquir Immune Defic Syndr View Researchers Basic research
Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer’s disease Dubey S, Heinen S, Krantic S, McLaurin J, Branch DR, Hynynen K, Aubert I 2020 PLoS Pathog View Researchers Basic research
Proliferative and Regenerative Effect of Acetonic Extract of Feijoa sellowiana on Stem Cells Rasekh H, Hoseini Farahi M, Mehrabani D, Massoumi SJ, Ramzi M, Acker JP 2020 World J Plast Surg View Researchers Basic research
Stepwise Reversion of Multiply Mutated Recombinant Antitrypsin Reveals a Selective Inhibitor of Coagulation Factor XIa as Active as the M358R Variant Hamada M, Bhakta V, Andres SN, Sheffield WP 2021 Front Cardiovasc Med View Researchers Basic research
Estimating SARS-CoV-2 Seroprevalence in Canadian Blood Donors, April 2020 to March 2021: Improving Accuracy with Multiple Assays Tuite AR, Fisman D, Abe KT, Rathod B, Pasculescu A, Colwill K, Gingras A-C, Yi Q-L, O’Brien SF, Drews SJ, Pride DT 2022 Microbiol Spectr View Researchers Basic research
Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review Saeed S, Uzicanin S, Lewin A, Lieshout-Krikke R, Faddy H, Erikstrup C, Osiowy C, Seed CR, Steele WR, Davison K, Custer B, O'Brien SF, Assessment SR, Policy Sub-group of the Transfusion Transmitted Infectious Diseases Working Party of the International Society of Blood Transfusion 2022 Vox Sang View Researchers Basic research
Novel Mechanisms of Thrombopoietin Generation: The Essential Role of Kupffer Cells Karakas D, Li J, Ni H 2021 Blood View Researchers Basic research
Anti-platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein Greinacher A, Selleng K, Mayerle J, Palankar R, Wesche J, Reiche S, Aebischer A, Warkentin TE, Muenchhoff M, Hellmuth JC, Keppler OT, Duerschmied D, Lother A, Rieg S, Gawaz MP, Mueller KAL, Scheer CS, Napp M, Hahnenkamp K, Lucchese G, Vogelgesang A, Flöel A, Lovreglio P, Stufano A, Marschalek R, Thiele T 2021 Blood View Researchers Clinical research
Risk factors for neonatal thrombosis: A retrospective study conducted in a single Canadian intensive care unit Bhatia K, Solanki S, Paes B, Chan AKC, Bhatt MD 2022 Pediatr Blood Cancer View Researchers Clinical research
Mitapivat versus Placebo for Pyruvate Kinase Deficiency Al-Samkari H, Galactéros F, Glenthøj A, Rothman JA, Andres O, Grace RF, Morado-Arias M, Layton DM, Onodera K, Verhovsek M, Barcellini W, Chonat S, Judge MP, Zagadailov E, Xu R, Hawkins P, Beynon V, Gheuens S, van Beers EJ 2022 N Engl J Med View Researchers Clinical research
Chemokines IP-10/CXCL10 and IL-8/CXCL8 are potential novel biomarkers of warm autoimmune hemolytic anemia Branch DR, Leger RM, Sakac d, Yi Q, Duong T, Yeung RSM, Binnington B, Bloch EM 2022 Blood Adv View Researchers Basic research
Adjudicating the Diagnosis of Immune Thrombocytopenia in a Clinical Research Study Gabe C, Mahamad S, John M, Duncan J, Kelton J, Arnold D 2023 TH Open View Researchers Clinical research
Hepatitis B Blood Donor Screening Data: An Under-Recognized Resource for Canadian Public Health Surveillance O’Brien SF, Reedman CN, Osiowy C, Bolotin S, Yi Q-L, Lourenço L, Lewin A, Binka M, Caffrey N, Drews SJ 2023 Viruses View Researchers Clinical research
Rapid potency assessment of autologous peripheral blood stem cells by intracellular flow cytometry: the PBSC-IL-3-pSTAT5 assay Simard C, Fournier D, Pineault N, Trépanier P 2022 Cytotherapy View Researchers New or improved product or process
Altered timing of riboflavin and ultraviolet light pathogen inactivation improves platelet in vitro quality Schubert P, Culibrk B, Karwal S, Serrano K, Levin E, Yi Q, Thiele T, Greinacher A, Marschner S, Devine DV 2017 Transfusion View Researchers New or improved product or process
Apixaban for treatment of confirmed heparin-induced thrombocytopenia: a case report and review of literature Ezekwudo DE, Chacko R, Gbadamosi B, Batool S, Gaikazian S, Warkentin TE, Sheppard JI, Jaiyesimi I 2017 Exp Hematol Oncol View Researchers Clinical research
Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors D'Aragon F, Dhanani S, Lamontagne F, Cook DJ, Burns K, Akhtar A, Chasse M, Frenette AJ, Keenan S, Lize JF, Kutsogiannis DJ, Kramer A, Hand LE, Arseneau E, Masse MH, Ribic C, Ball I, Baker A, Boyd G, Rochwerg B, Healey A, Hanna S, Guyatt GH, Meade MO 2017 BMJ Open View Researchers Clinical research
Concentré de recherche: Un modèle de changement : prédiction de l'impact d'améliorations à  l'échelle du système Blake J 2018 Blood.ca website View Researchers Basic research
Determination of the biological form of human cytomegalovirus DNA in the plasma of solid-organ transplant recipients Tong Y, Pang XL, Mabilangan C, Preiksaitis JK 2017 J Infect Dis View Researchers Clinical research
Eltrombopag after allogeneic haematopoietic cell transplantation in a case of poor graft function and systematic review of the literature Dyba J, Tinmouth A, Bredeson C, Matthews J, Allan DS 2016 Transfus Med View Researchers Clinical research
Fibronectin maintains the balance between hemostasis and thrombosis Wang Y, Ni H 2016 Cell Mol Life Sci View Researchers Basic research
Immunity against a therapeutic xenoprotein/Fc construct delivered by gene transfer is reduced through binding to the inhibitory receptor Fc?RIIb Liang Y, Qiu H, Glinka Y, Lazarus AH, Ni H, Prud'homme GJ, Wang Q 2011 J Gene Med View Researchers Basic research
In vivo clearance of alpha-1 acid glycoprotein is influenced by the extent of its N-linked glycosylation and by its interaction with the vessel wall McCurdy TR, Bhakta V, Eltringham-Smith LJ, Gataiance S, Fox-Robichaud AE, Sheffield WP 2012 J Biomed Biotechnol View Researchers Basic research
Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia Tao L, Zeng Q, Li J, Xu M, Wang J, Pan Y, Wang H, Tao Q, Chen Y, Peng J, Hou M, Jansen AJG, Ni H, Zhai Z 2017 J Hematol Oncol View Researchers Clinical research
Predominant autoantibody response to GPIb/IX in a regulatory T-cell-deficient mouse model for immune thrombocytopenia Nishimoto T, Satoh T, Simpson EK, Ni H, Kuwana M 2013 J Thromb Haemost View Researchers Basic research
Relative efficacy of steroid therapy in immune thrombocytopenia mediated by anti-platelet GPIIbIIIa versus GPIb? antibodies Zeng Q, Zhu L, Tao L, Bao J, Yang M, Simpson EK, Li C, van der Wal DE, Chen P, Spring CM, Wang M, Zhang L, Ruan C, Hou M, Xia R, Ni H 2012 Am J Hematol View Researchers Clinical research
Small molecule phagocytosis inhibitors for immune cytopenias Neschadim A, Kotra LP, Branch DR 2016 Autoimmun Rev View Researchers Basic research
Synthesis of peptides and glycopeptides with polyproline II helical topology as potential antifreeze molecules Corcilius L, Santhakumar G, Stone RS, Capicciotti CJ, Joseph S, Matthews JM, Ben RN, Payne RJ 2013 Bioorg Med Chem View Researchers Basic research
The expanding family of bone marrow homing factors for hematopoietic stem cells: stromal derived factor 1 is not the only player in the game Ratajczak MZ, Kim C, Janowska-Wieczorek A, Ratajczak J 2012 ScientificWorldJournal View Researchers Basic research
The role of complement in the trafficking of hematopoietic stem/progenitor cells Janowska-Wieczorek A, Marquez-Curtis LA, Shirvaikar N, Ratajczak MZ 2012 Transfusion View Researchers Basic research
Transfusion medicine data as product Skeate RC 2013 Transfusion View Researchers Other
The association between blood donor sex and age and transfusion recipient mortality: an exploratory analysis Heddle NM, Cook RJ, Liu Y, Zeller M, Barty R, Acker JP, Eikelboom J, Arnold DM 2019 Transfusion View Researchers Clinical research
Evaluation of the functional properties of cryopreserved buffy coat-derived monocytes for monocyte monolayer assay Kipkeu BJ, Shyian ML, da Silveira Cavalcante L, Duong TT, Yeung RSM, Binnington B, Branch DR, Acker JP, Holovati JL 2018 Transfusion View Researchers Basic research
Severe hemolytic disease of the fetus and newborn due to allo-anti-D in a patient with a partial DEL phenotype arising from the variant allele described as RHD*148+1T (RHD*01EL.31) Turley E, McGowan EC, Hyland CA, Schoeman EM, Flower RL, Skoll A, Delisle MF, Nelson T, Clarke G, Au N 2018 Transfusion View Researchers Clinical research
Age-Separated RBCs Show Changes in Oxygen Carrying Capacity and Rigidity During Hypothermic Storage Mykhailova O, Li W, Acker J 2019 Probl Cryobiol Cryomed View Researchers Basic research
Decoding the metabolic landscape of pathophysiological stress-induced cell death in anucleate red blood cells Nemkov T, Qadri SM, Sheffield WP, D'Alessandro A 2020 Blood Transfus View Researchers Basic research
Human leukocyte antigen-G upregulates immunoglobulin-like transcripts and corrects dysfunction of immune cells in immune thrombocytopenia Li X, Sheng Z, Sun Y, Wang Y, Xu M, Zhang Z, Li H, Shao L, Zhang Y, Yu J, Ma C, Gao C, Hou M, Ni H, Peng J, Ma J, Feng Q 2020 Haematologica View Researchers Basic research
Multi-laboratory assay for harmonization of enumeration of viable CD34+ and CD45+ cells in frozen cord blood units Fournier D, Lewin A, Simard C, Trépanier P, Néron S, Ballerini L, Codinach M, Elmoazzen H, Halpenny M, Kogler G, Liedtke S, Louis I, Molluna CA, Pineault N, Prasath A, Querol S, Saccardi R, Sutherland DR, Thérien C, Urbani S 2020 Cytotherapy View Researchers Benchmarking and standard setting
Using umbilical cord blood for regenerative therapy: Proof or promise? Allan DS 2020 Stem Cells View Researchers Clinical research
Concentré de recherche: Les dons de sang effectués avant la grossesse sont sans danger pour les mères et les bébés Chassé M 2020 Blood.ca website Researchers Clinical research
Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials Lawati KA, Sharif S, Maqbali SA, Rimawi HA, Petrosoniak A, Belley-Cote EP, Sharma SV, Morgenstern J, Fernando SM, Owen JJ, Zeller M, Quinlan D, Alhazzani W, Rochwerg B 2021 Intensive Care Med Researchers Clinical research
Identification of an alpha-1 antitrypsin variant with enhanced specificity for factor XIa by phage display, bacterial expression, and combinatorial mutagenesis Bhakta V, Hamada M, Nouanesengsy A, Lapierre J, Perruzza DL, Sheffield WP 2021 Sci Rep View Researchers Basic research
Multimerin 1 supports platelet function in vivo and binds to specific GPAGPOGPX motifs in fibrillar collagens that enhance platelet adhesion Leatherdale A, Parker DA, Tasneem S, Wang Y, Bihan D, Bonna A, Hamaia SW, Gross PL, Ni H, Doble BW, Lillicrap D, Farndale RW, Hayward CPM 2021 J Thromb Haemost View Researchers Basic research
Research initiatives of blood services worldwide in response to the covid-19 pandemic O'Brien SF, Lieshout-Krikke RW, Lewin A, Erikstrup C, Steele WR, Uzicanin S, Custer B, the Surveillance RA, Policy Sub-group of the ISBT Transfusion Transmitted Infectious Diseases Working Party 2021 Vox Sang View Researchers Clinical research
Systematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism Patel P, Patel P, Bhatt M, Braun C, Begum H, Nieuwlaat R, Khatib R, Martins CC, Zhang Y, Etxeandia-Ikobaltzeta I, Varghese J, Alturkmani H, Bahaj W, Baig M, Kehar R, Mustafa A, Ponnapureddy R, Sethi A, Thomas M, Wooldridge D, Lim W, Bates SM, Lang E, Le Gal G, Haramati LB, Kline J, Righini M, Wiercioch W, Schünemann H, Mustafa RA 2021 Blood Adv View Researchers Clinical research
In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIb? Li BX, Dai X, Xu XR, Adili R, Neves MAD, Lei X, Shen C, Zhu G, Wang Y, Zhou H, Hou Y, Ni T, Pasman Y, Yang Z, Qian F, Zhao Y, Gao Y, Liu J, Teng M, Marshall AH, Cerenzia EG, Li ML, Ni H 2021 Sci Rep View Researchers Clinical research
Characteristics of Anti-SARS-CoV-2 Antibodies in Recovered COVID-19 Subjects Huynh A, Arnold DM, Smith JW, Moore JC, Zhang A, Chagla Z, Harvey BJ, Stacey HD, Ang JC, Clare R, Ivetic N, Chetty VT, Bowdish DME, Miller MS, Kelton JG, Nazy I 2021 Viruses View Researchers Clinical research
An international comparison of HIV prevalence and incidence in blood donors and general population: a BEST Collaborative study Germain M, Grégoire Y, Custer BS, Goldman M, Bravo M, Kamel H, Davison K, Field S, van den Hurk K, van de Laar TJW, Irving DO, Jones A, Liumbruno G, Morley S, O’Brien SF, Pillonel J, Steinsvåg CT, Takanashi M, Tsuno NH, Vesga Carasa MA, Wendel S, Vassallo RR, Tiberghien P, for the BEST Collaborative 2021 Vox Sang View Researchers Benchmarking and standard setting
Characterizing Frailty In Myeloproliferative Neoplasms: results from the ORCHID study Chornenki NLJ, Siegal DM, Qamar K, Woolgar S, Rangarajan S, Karampatos S, Leong DP, Hillis CM 2022 Leuk Res View Researchers Clinical research