Our Funded Research Projects
Updated February 2025
| Title | Principal Investigator / Supervisor | Program Sort descending | Project Start Date | Project End Date | Total $ Awarded |
|---|---|---|---|---|---|
| Impact of storage on the function of cord blood hematopoietic stem and progenitor cells | Principal Investigator: PINEAULT, Nicolas Co-Investigator(s) / Trainee: JAHAN, Suria |
Graduate Fellowship Program | $104,000 | ||
| External validation of a prediction model for diagnosing immune thrombocytopenia | Principal Investigator: ARNOLD, Donald Co-Investigator(s) / Trainee: MAHAMAD, Syed |
Graduate Fellowship Program | $70,000 | ||
| Synthesis of carbohydrate derivatives for the improvement of red blood cell storage | Principal Investigator: BEN, Robert Co-Investigator(s) / Trainee: MEYER, Julia |
Graduate Fellowship Program | $79,500 | ||
| Perioperative transfusion threshold : A population-based observational study | Principal Investigator: FERGUSSON, Dean Co-Investigator(s) / Trainee: VERRET, Michael |
Graduate Fellowship Program | $52,000 | ||
| Towards the impact of protein synthesis in human platelets to transfusion medicine | Principal Investigator: DEVINE, Dana Co-Investigator(s) / Trainee: BOSGOED, Christa |
Graduate Fellowship Program | $92,000 | ||
| Small molecule inhibitors of phagocytosis to replace intravenous immunoglobulin (IVIG) | Principal Investigator: BRANCH, Donald Co-Investigator(s) / Trainee: TONG, Tik Nga (Cindy) |
Graduate Fellowship Program | $52,000 | ||
| Ice Recrystallization Inhibitors as a Glycerol Replacement in Red Blood Cell Cryopreservation | Principal Investigator: BEN, Robert Co-Investigator(s) / Trainee: WALSH, Ellyssa |
Graduate Fellowship Program | $70,000 | ||
| Investigating a new class of small molecule ice recrystallization inhibitors for red blood cell cryopreservation | Principal Investigator: BEN, Robert Co-Investigator(s) / Trainee: AMPAW, Anna |
Graduate Fellowship Program | $104,000 | ||
| Donor factors and product quality | Principal Investigator: ACKER, Jason Co-Investigator(s) / Trainee: YAZDANBAKHSH, Mahsa |
Graduate Fellowship Program | $122,000 | ||
| Role of skin disinfection and buffy coat platelet production on residual bacterial contamination in platelet concentrates and cord blood stem cells | Principal Investigator: RAMIREZ-ARCOS, Sandra Co-Investigator(s) / Trainee: TAHA, Mariam |
Graduate Fellowship Program | $92,000 | ||
| Study of the mechanisms implicated in platelets microparticle internalization by blood cells | Principal Investigator: BOILARD, Eric Co-Investigator(s) / Trainee: MARCOUX, Genevieve |
Graduate Fellowship Program | $104,000 | ||
| Accelerating the clinical translation of hematopoietic stem cell gene editing to correct hemoglobin disorders | Principal Investigator: MAGANTI, Harinad Co-Investigator(s) / Trainee: HANOTAUX, Justine |
Graduate Fellowship Program | $70,000 | ||
| Evaluation and improvement of cold stored platelets | Principal Investigator: DEVINE, Dana Co-Investigator(s) / Trainee: ZHAO, Hanqi (Wayne) |
Graduate Fellowship Program | $104,000 | ||
| Studies on the development of biocompatible antimicrobial platelet storage devices | Principal Investigator: BROOKS, Don Co-Investigator(s) / Trainee: HADJESFANDIARI, Narges |
Graduate Fellowship Program | $96,000 | ||
| Mechanisms of anti-αIIb mediated miscarriage in fetal and neonatal alloimmune thrombocytopenia | Principal Investigator: NI, Heyu Co-Investigator(s) / Trainee: CHEN, Zi Yan |
Graduate Fellowship Program | $52,000 | ||
| Recombinant Fc multimers to replace IVIG | Principal Investigator: BRANCH, Donald Co-Investigator(s) / Trainee: LEWIS, Bonnie |
Graduate Fellowship Program | $104,000 | ||
| Anti-GPIb mediated thrombocytopenia: implications for IVIG and other therapies | Principal Investigator: NI, Heyu Co-Investigator(s) / Trainee: XU, Miao |
Graduate Fellowship Program | $52,000 | ||
| Assessment of fluorinated ice crystallization inhibitors: cryopreservation of hematopoietic stem cells and red blood cells | Principal Investigator: BEN, Robert Co-Investigator(s) / Trainee: BRIARD, Jennie |
Graduate Fellowship Program | $96,000 | ||
| Assessing the relationship between red blood cell deformability and transfusion lifetime | Principal Investigator: MA, Hongshen Co-Investigator(s) / Trainee: LAMOUREUX, Erik |
Graduate Fellowship Program | $122,000 | ||
| Dengue virus replication by anucleate cells: impact on pathogen reduction efficacy | Principal Investigator: PRYZDIAL, Ed Co-Investigator(s) / Trainee: FELGENHAUER, Ulrike |
Graduate Fellowship Program | $52,000 | ||
| Deformability based cell sorting enabling quality control of stored red blood cells | Principal Investigator: MA, Hongshen Co-Investigator(s) / Trainee: ISLAMZADA, Emel |
Graduate Fellowship Program | $112,333 | ||
| Identification of protein biomarkers for red cell quality | Principal Investigator: DEVINE, Dana Co-Investigator(s) / Trainee: CHEN, Deborah |
Graduate Fellowship Program | $100,000 | ||
| Defining the stem cell regulatory functions of GAS6 and FTO | Principal Investigator: MAGANTI, Harinad Co-Investigator(s) / Trainee: PASALA, Ajay |
Graduate Fellowship Program | $122,000 | ||
| Platelet desialylation: novel mechanism of platelet clearance and immune tolerance | Principal Investigator: NI, Heyu Co-Investigator(s) / Trainee: LI, June |
Graduate Fellowship Program | $104,000 | ||
| A novel clot-dissolving agent derived from clotting factor Va | Principal Investigator: PRYZDIAL, Ed Co-Investigator(s) / Trainee: LEE, Frank |
Graduate Fellowship Program | $39,500 | ||
| The in vivo effects of liposome treatment on minimizing membrance injury in rat red blood cells during hypothermic storage | Principal Investigator: HOLOVATI, Jelena Co-Investigator(s) / Trainee: da SILVIERA CAVALCANTE, Luciana |
Graduate Fellowship Program | $100,000 | ||
| Generation of a coagulation factor-based thrombotic agent | Principal Investigator: PRYZDIAL, Ed Co-Investigator(s) / Trainee: WITT, Alexandra |
Graduate Fellowship Program | $122,000 | ||
| Small molecule ice recrystallization inhibitors as cryo-additives for red blood cell cryopreservation | Principal Investigator: BEN, Robert Co-Investigator(s) / Trainee: POISSON, Jessica |
Graduate Fellowship Program | $82,000 | ||
| Monoclonal antibodies with anti-D like activity in amelioration of murine ITP | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: KHAN, Ramsha |
Graduate Fellowship Program | $52,000 | ||
| MRI guided focused ultrasound facilitated IVIg immunotherapy as a therapeutic approach for Alzheimer's disease | Principal Investigator: AUBERT, Isabelle Co-Investigator(s) / Trainee: DUBEY, Sonam |
Graduate Fellowship Program | $100,000 | ||
| Modified platelet storage containers to improve quality during storage | Principal Investigator: KIZHAKKEDATHU, Jayachandran Co-Investigator(s) / Trainee: PEREYRA DOS SANTOS, Nicolas |
Graduate Fellowship Program | $122,000 | ||
| Monoclonal antibodies with anti-D-like activity in the amelioration of murine immune thrombocytopenia (ITP) | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: SEMPLE, John W., NI, Heyu |
Intramural Research Grant Program | $400,000 | ||
| Plasma transfusion or plasma protein product infusion in a murine model of trauma | Principal Investigator: SHEFFIELD, William Co-Investigator(s) / Trainee: PRYZDIAL, Edward |
Intramural Research Grant Program | $257,415 | ||
| Revisiting the universal donor: Does exposure to O blood products affect patient outcomes? | Principal Investigator: ARNOLD, Donald Co-Investigator(s) / Trainee: ACKER, Jason, BUCKSTEIN, Rena, CALLUM, Jeannie, COOK, Richard, HEDDLE, Nancy, SOLH, Ziad, WEBERT, Kathryn, BARTY, Rebecca, LEBER, Brian, LALIT, Saini |
Intramural Research Grant Program | $378,365 | ||
| RBC hemolysis and cellular effector mechanisms (RHANCEM) | Principal Investigator: BRANCH, Donald Co-Investigator(s) / Trainee: CSERTI-GAZDEWICH, Christine, PENDERGRAST,Jacob, CALLUM, Jeannie, YI, Qilong |
Intramural Research Grant Program | $399,927 | ||
| Role of blood component manufacturing on microvesicle-induced transfusion-related immune modulation | Principal Investigator: ACKER, Jason Co-Investigator(s) / Trainee: HOLOVATI, Jelena, BRANCH, Donald, ZHANG, Haibo |
Intramural Research Grant Program | $250,660 | ||
| Small molecule drug development of phagocytosis inhibitors | Principal Investigator: BRANCH, Donald Co-Investigator(s) / Trainee: KOTRA, Lakshmi, P. |
Intramural Research Grant Program | $428,468 | ||
| PREMISE: Point-of-care hemoglobin accuracy and transfusion outcomes in non-cardiac surgery | Principal Investigator: MARTEL, Guillaume Co-Investigator(s) / Trainee: TINMOUTH, Alan, FERGUSSON, Dean, MCISAAC, Daniel, SHAW, Julie, RAMSAY, Tim, PRESSEAU, Justin, WHERRETT, Christopher, CARRIER, François-Martin, SEELY, Andrew, BRYSON, Gregory |
Intramural Research Grant Program | $392,974 | ||
| Human monoclonal CD44 antibodies as potential IVIg replacements | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: NI, Heyu |
Intramural Research Grant Program | $336,000 | ||
| A clinical comparison of cold-stored and room temperature-stored allogeneic platelet transfusions in bleeding adult cardiac surgery patients - A randomized multicentre pilot study (PLTS-1 study) | Principal Investigator: BARTOSZKO, Justyna Co-Investigator(s) / Trainee: CALLUM, Jeannie, DEVINE, Dana, KARKOUTI, Keyvan, KAHR, Walter, MCVEY, Mark, PEER, Miki, RAO, Vivek, ABRAHAMYAN, Lusine, LIEBERMAN, Lani, MEWHORT, Holly |
Intramural Research Grant Program | $242,617 | ||
| Anti-GPIb- and anti-GPIIbIIIa- mediated immune thrombocytopenia: Mechanisms and actions of intravenous IgG (IVIG) and alternative therapies | Principal Investigator: NI, Heyu Co-Investigator(s) / Trainee: LAZARUS, Alan, BRANCH, Donald |
Intramural Research Grant Program | $412,010 | ||
| Anti-RBC monoclonal antibodies as a replacement for IVIg and anti-D in ITP | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: BRANCH, Donald, DUNN, Shannon |
Intramural Research Grant Program | $400,000 | ||
| Plasma versus plasma protein concentrate transfusion for coagulopathic control | Principal Investigator: SHEFFIELD, William Co-Investigator(s) / Trainee: NI, Heyu |
Intramural Research Grant Program | $224,417 | ||
| Fc receptors and IVIg in ITP | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: CSERTI-GAZDEWICH, Christine, LIN, Yulia, CALLUM, Jeannie, SHOLZBERG, Michelle, NI, Heyu |
Intramural Research Grant Program | $432,000 | ||
| Mechanisms of erythrocyte antibody-mediated immune suppression | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: NI, Heyu, SEMPLE, John |
Intramural Research Grant Program | $400,000 | ||
| The threshold or operative hemoglobin trigger for red blood cell transfustion pilot trial (TOPGUN-pilot) | Principal Investigator: MARTEL, Guillaume Co-Investigator(s) / Trainee: MCISAAC, Daniel, FERGUSSON, Dean, TINMOUTH, Alan, BREAU, Rodney, CARRIER, Francois Martin, VERRET, Michael, TALJAARD, Monica, BROUSSEAU, Karine |
Intramural Research Grant Program | $400,000 | ||
| A multifaceted intervention to optimize red blood cell transfusion practice in two provinces | Principal Investigator: WEBERT, Kathryn Co-Investigator(s) / Trainee: NAHIRNIAK, Susan, CALLUM, Jeannie, LIN, Yulia, ZELLER, Michelle |
Intramural Research Grant Program | $332,942 | ||
| IN-TRUST: Using a transfusion database to explore the immune-modulatory impacts of blood transfusion and the clinical impacts of blood processing changes | Principal Investigator: NING, Shuoyan Co-Investigator(s) / Trainee: ARNOLD, Donald, ZELLER, Michelle, ACKER, Jason, LI, Na, HEDDLE, Nancy, HILLIS, Christopher, ROCHWERG, Bram, SYED, Summer |
Intramural Research Grant Program | $270,352 | ||
| Can pre-operative anemia be timely identified and optimized in patients awaiting primary arthroplasty surgery? A randomized clinical trial | Principal Investigator: GRAMMATOPOULOS, George Co-Investigator(s) / Trainee: FERGUSSON, Dean, RAMSAY, Tim, TINMOUTH, Alan, GAGNE, Sylvain, MACK, Johnathan, BELZILE, Etienne, BEALE, Paul, THAVORN, Kednapa, TOUCHIE, Donna, GERMAIN, Genevieve, LAROCHE, Vincent |
Intramural Research Grant Program | $276,081 | ||
| Improving blood product quality | Principal Investigator: DEVINE, Dana Co-Investigator(s) / Trainee: MA, Hongshen, JOHNSON, James, D'ALESSANDRO, Angelo |
Intramural Research Grant Program | $304,462 |