Our Funded Research Projects
Updated April 2024
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Title | Principal Investigator / Supervisor | Program Sort descending | Project Start Date | Project End Date | Total $ Awarded |
---|---|---|---|---|---|
Novel cell-surface engineering methods to increase immune-tolerance of allogenic cell transplantation | Principal Investigator: KIZHAKKEDATHU, Jayachandran Co-Investigator(s) / Trainee: MOON, Haisle |
Graduate Fellowship Program | 90333.3 | ||
Synthesis and live cell imaging of ice recrystallization inhibitors in red blood cells | Principal Investigator: BEN, Robert Co-Investigator(s) / Trainee: MCMUNN, Leah |
Graduate Fellowship Program | 112333.0 | ||
Replacing plasma-derived C1 Esterase inhibitor | Principal Investigator: SHEFFIELD, William Co-Investigator(s) / Trainee: SIVANANTHAN, Sangavi |
Graduate Fellowship Program | 70000.0 | ||
Investigation of pathophysiology, prevention and treatment of murine Transfusion Related Acute Lung Injury (TRALI) | Principal Investigator: SEMPLE, John Co-Investigator(s) / Trainee: McVEY, Mark |
Graduate Fellowship Program | 52000.0 | ||
Studying and alleviating the effects of platelet microparticles induced by pathogen reduction of platelet concentrates | Principal Investigator: PROVOST, Patrick Co-Investigator(s) / Trainee: LAUGIER, Jonathan |
Graduate Fellowship Program | 52000.0 | ||
Replacement of IVIg by small molecule inhibitors of phagocytosis | Principal Investigator: BRANCH, Donald Co-Investigator(s) / Trainee: LORIAMINI, Melika |
Graduate Fellowship Program | 112333.0 | ||
CD71 Erythroid Cells, RBC Clearance and Sepsis in Donor - Recipient Sex- Mismatched Transfusion | Principal Investigator: ACKER, Jason Co-Investigator(s) / Trainee: LI, Wenhui |
Graduate Fellowship Program | 70000.0 | ||
Impact of storage on the function of cord blood hematopoietic stem and progenitor cells | Principal Investigator: PINEAULT, Nicolas Co-Investigator(s) / Trainee: JAHAN, Suria |
Graduate Fellowship Program | 104000.0 | ||
Synthesis of carbohydrate derivatives for the improvement of red blood cell storage | Principal Investigator: BEN, Robert Co-Investigator(s) / Trainee: MEYER, Julia |
Graduate Fellowship Program | 79500.0 | ||
Transcriptome analyses of Staphylococcus aureus grown in platelet concentrates with focus on virulence | Principal Investigator: RAMIREZ-ARCOS, Sandra Co-Investigator(s) / Trainee: DA SILVA PAREDES, Carina |
Graduate Fellowship Program | 122000.0 | ||
Fc receptor blockade related to fetal and neonatal alloimmune thrombocytopenia | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: TAWHIDI, Zoya |
Graduate Fellowship Program | 70000.0 | ||
Cellular therapy to improve CD4+ T-Cell responses in humanized mice infected with HIV-1: adoptive transfer of CD4+ T-cells lacking s-Src activity | Principal Investigator: BRANCH, Donald Co-Investigator(s) / Trainee: McCARTHY, Stephen |
Graduate Fellowship Program | 96000.0 | ||
Investigating the mechanism of anti-CD44 antibody amelioration of IVIg-treatable disease | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: NORRIS, Peter |
Graduate Fellowship Program | 112333.3 | ||
Assessment of fluorinated ice crystallization inhibitors: cryopreservation of hematopoietic stem cells and red blood cells | Principal Investigator: BEN, Robert Co-Investigator(s) / Trainee: BRIARD, Jennie |
Graduate Fellowship Program | 96000.0 | ||
Perioperative transfusion threshold : A population-based observational study | Principal Investigator: FERGUSSON, Dean Co-Investigator(s) / Trainee: VERRET, Michael |
Graduate Fellowship Program | 52000.0 | ||
Small molecule inhibitors of phagocytosis to replace intravenous immunoglobulin (IVIG) | Principal Investigator: BRANCH, Donald Co-Investigator(s) / Trainee: TONG, Tik Nga (Cindy) |
Graduate Fellowship Program | 52000.0 | ||
Investigating a new class of small molecule ice recrystallization inhibitors for red blood cell cryopreservation | Principal Investigator: BEN, Robert Co-Investigator(s) / Trainee: AMPAW, Anna |
Graduate Fellowship Program | 112333.3 | ||
Identification of protein biomarkers for red cell quality | Principal Investigator: DEVINE, Dana Co-Investigator(s) / Trainee: CHEN, Deborah |
Graduate Fellowship Program | 100000.0 | ||
Donor factors and product quality | Principal Investigator: ACKER, Jason Co-Investigator(s) / Trainee: YAZDANBAKHSH, Mahsa |
Graduate Fellowship Program | 122000.0 | ||
Recombinant Fc multimers to replace IVIG | Principal Investigator: BRANCH, Donald Co-Investigator(s) / Trainee: LEWIS, Bonnie |
Graduate Fellowship Program | 104000.0 | ||
Evaluation and improvement of cold stored platelets | Principal Investigator: DEVINE, Dana Co-Investigator(s) / Trainee: ZHAO, Hanqi (Wayne) |
Graduate Fellowship Program | 112333.3 | ||
The in vivo effects of liposome treatment on minimizing membrance injury in rat red blood cells during hypothermic storage | Principal Investigator: HOLOVATI, Jelena Co-Investigator(s) / Trainee: da SILVIERA CAVALCANTE, Luciana |
Graduate Fellowship Program | 100000.0 | ||
Mechanisms of anti-αIIb mediated miscarriage in fetal and neonatal alloimmune thrombocytopenia | Principal Investigator: NI, Heyu Co-Investigator(s) / Trainee: CHEN, Zi Yan |
Graduate Fellowship Program | 52000.0 | ||
Study of the mechanisms implicated in platelets microparticle internalization by blood cells | Principal Investigator: BOILARD, Eric Co-Investigator(s) / Trainee: MARCOUX, Genevieve |
Graduate Fellowship Program | 104000.0 | ||
Anti-GPIb mediated thrombocytopenia: implications for IVIG and other therapies | Principal Investigator: NI, Heyu Co-Investigator(s) / Trainee: XU, Miao |
Graduate Fellowship Program | 52000.0 | ||
A clinical comparison of cold-stored and room temperature-stored allogeneic platelet transfusions in bleeding adult cardiac surgery patients - A randomized multicentre pilot study (PLTS-1 study) | Principal Investigator: BARTOSZKO, Justyna Co-Investigator(s) / Trainee: CALLUM, Jeannie, DEVINE, Dana, KARKOUTI, Keyvan, KAHR, Walter, MCVEY, Mark, PEER, Miki, RAO, Vivek, ABRAHAMYAN, Lusine, LIEBERMAN, Lani, MEWHORT, Holly |
Intramural Research Grant Program | 242617.0 | ||
Defining the components of transfusable plasma that reduce bleeding | Principal Investigator: SHEFFIELD, William Co-Investigator(s) / Trainee: PRYZDIAL, Edward, NI, Heyu |
Intramural Research Grant Program | 218230.0 | ||
TAD-POL (Transfusion-Associated-Dyspnea: Prospective observation and laboratory assessment) | Principal Investigator: CSERTI-GAZDEWICH, Christine Co-Investigator(s) / Trainee: BRANCH, Donald, LAZARUS, Alan, CALLUM, Jeannie, LIN, Yulia, PENDERGRAST, Jacob, LIEBERMAN, Lani, SHEHATA, Nadine, PAVENSKI, Katerina, SKEATE, Robert |
Intramural Research Grant Program | 278027.5 | ||
Development of porcine equivalent RCC and plasma units for translatable ex vivo organ perfusion research | Principal Investigator: ACKER, Jason Co-Investigator(s) / Trainee: FREED, Darren |
Intramural Research Grant Program | 121834.0 | ||
Fc receptor blockade in transfusion medicine | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: NI, Heyu, GUPTA, Akash, SHEHATA, Nadine, KJELDSEN-KRAGH, Jens, NEWMAN, Peter J., CSERTI-GAZDEWICH, Christine, RAVETCH, Jeffery |
Intramural Research Grant Program | 400000.0 | ||
Development of a small molecule cocktail for the expansion of cord blood stem cells | Principal Investigator: PINEAULT, Nicolas Co-Investigator(s) / Trainee: BLAKE, John, AUDET, Julie |
Intramural Research Grant Program | 237600.0 | ||
PREMISE: Point-of-care hemoglobin accuracy and transfusion outcomes in non-cardiac surgery | Principal Investigator: MARTEL, Guillaume Co-Investigator(s) / Trainee: TINMOUTH, Alan, FERGUSSON, Dean, MCISAAC, Daniel, SHAW, Julie, RAMSAY, Tim, PRESSEAU, Justin, WHERRETT, Christopher, CARRIER, François-Martin, SEELY, Andrew, BRYSON, Gregory |
Intramural Research Grant Program | 392974.0 | ||
Monoclonal antibodies with anti-D-like activity in the amelioration of murine immune thrombocytopenia (ITP) | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: SEMPLE, John W., NI, Heyu |
Intramural Research Grant Program | 400000.0 | ||
Small molecule inhibitors of phagocytosis | Principal Investigator: BRANCH, Donald Co-Investigator(s) / Trainee: KOTRA, Lakshmi P. |
Intramural Research Grant Program | 399130.0 | ||
Plasma transfusion or plasma protein product infusion in a murine model of trauma | Principal Investigator: SHEFFIELD, William Co-Investigator(s) / Trainee: PRYZDIAL, Edward |
Intramural Research Grant Program | 257414.8 | ||
Anti-RBC monoclonal antibodies as a replacement for IVIg and anti-D in ITP | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: BRANCH, Donald, DUNN, Shannon |
Intramural Research Grant Program | 400000.0 | ||
Role of blood component manufacturing on microvesicle-induced transfusion-related immune modulation | Principal Investigator: ACKER, Jason Co-Investigator(s) / Trainee: HOLOVATI, Jelena, BRANCH, Donald, ZHANG, Haibo |
Intramural Research Grant Program | 250660.0 | ||
Can pre-operative anemia be timely identified and optimized in patients awaiting primary arthroplasty surgery? A randomized clinical trial | Principal Investigator: GRAMMATOPOULOS, George Co-Investigator(s) / Trainee: FERGUSSON, Dean, RAMSAY, Tim, TINMOUTH, Alan, GAGNE, Sylvain, MACK, Johnathan, BELZILE, Etienne, BEALE, Paul, THAVORN, Kednapa, TOUCHIE, Donna, GERMAIN, Genevieve, LAROCHE, Vincent |
Intramural Research Grant Program | 276081.0 | ||
Small molecule drug development of phagocytosis inhibitors | Principal Investigator: BRANCH, Donald Co-Investigator(s) / Trainee: KOTRA, Lakshmi, P. |
Intramural Research Grant Program | 428468.4 | ||
Translating novel clotting factor X function to treat thrombosis | Principal Investigator: PRYZDIAL, Ed Co-Investigator(s) / Trainee: MACVICAR, Brian, SHEFFIELD, William |
Intramural Research Grant Program | 369052.0 | ||
Human monoclonal CD44 antibodies as potential IVIg replacements | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: NI, Heyu |
Intramural Research Grant Program | 336000.0 | ||
Anti-GPIb- and anti-GPIIbIIIa- mediated immune thrombocytopenia: Mechanisms and actions of intravenous IgG (IVIG) and alternative therapies | Principal Investigator: NI, Heyu Co-Investigator(s) / Trainee: LAZARUS, Alan, BRANCH, Donald |
Intramural Research Grant Program | 412010.3 | ||
Revisiting the universal donor: Does exposure to O blood products affect patient outcomes? | Principal Investigator: ARNOLD, Donald Co-Investigator(s) / Trainee: ACKER, Jason, BUCKSTEIN, Rena, CALLUM, Jeannie, COOK, Richard, HEDDLE, Nancy, SOLH, Ziad, WEBERT, Kathryn, BARTY, Rebecca, LEBER, Brian, LALIT, Saini |
Intramural Research Grant Program | 378365.0 | ||
Plasma versus plasma protein concentrate transfusion for coagulopathic control | Principal Investigator: SHEFFIELD, William Co-Investigator(s) / Trainee: NI, Heyu |
Intramural Research Grant Program | 224417.0 | ||
Fc receptors and IVIg in ITP | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: CSERTI-GAZDEWICH, Christine, LIN, Yulia, CALLUM, Jeannie, SHOLZBERG, Michelle, NI, Heyu |
Intramural Research Grant Program | 432000.0 | ||
Mechanisms of erythrocyte antibody-mediated immune suppression | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: NI, Heyu, SEMPLE, John |
Intramural Research Grant Program | 400000.0 | ||
A multifaceted intervention to optimize red blood cell transfusion practice in two provinces | Principal Investigator: WEBERT, Kathryn Co-Investigator(s) / Trainee: NAHIRNIAK, Susan, CALLUM, Jeannie, LIN, Yulia, ZELLER, Michelle |
Intramural Research Grant Program | 332942.0 | ||
IN-TRUST: Using a transfusion database to explore the immune-modulatory impacts of blood transfusion and the clinical impacts of blood processing changes | Principal Investigator: NING, Shuoyan Co-Investigator(s) / Trainee: ARNOLD, Donald, ZELLER, Michelle, ACKER, Jason, LI, Na, HEDDLE, Nancy, HILLIS, Christopher, ROCHWERG, Bram, SYED, Summer |
Intramural Research Grant Program | 270352.1 | ||
RBC hemolysis and cellular effector mechanisms (RHANCEM) | Principal Investigator: BRANCH, Donald Co-Investigator(s) / Trainee: CSERTI-GAZDEWICH, Christine, PENDERGRAST,Jacob, CALLUM, Jeannie, YI, Qilong |
Intramural Research Grant Program | 399927.3 | ||
Optimization of monoclonal anti-erythrocyte antibodies for improved immunoprophylaxis in a murine model | Principal Investigator: LAZARUS, Alan Co-Investigator(s) / Trainee: NI, Heyu |
Intramural Research Grant Program | 400000.0 |