Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Progress in RNAi-mediated Molecular Therapy of Acute and Chronic Myeloid Leukemia Landry B, Valencia-Serna J, Gul-Uludag H, Jiang X, Janowska-Wieczorek A, Brandwein J, Uludag H 2015 Mol Ther Nucleic Acids View Researchers Other
Red blood cell membrane water permeability increases with length of ex vivo storage Alshalani A, Acker JP 2017 Cryobiology View Researchers Basic research
Residual risk of bacterial contamination of platelets: six years of experience with sterility testing Ramirez-Arcos S, DiFranco C, McIntyre T, Goldman M 2017 Transfusion View Researchers New or improved product or process
Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa Donkor DA, Bhakta V, Eltringham-Smith LJ, Stafford AR, Weitz JI, Sheffield WP 2017 Sci Rep View Researchers Basic research
The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand Boyle AJ, Roddick LA, Bhakta V, Lambourne MD, Junop MS, Liaw PC, Weitz JI, Sheffield WP 2013 BMC Biochem View Researchers Basic research
The mechanism and modulation of complement activation on polymer grafted cells Leung VL, Kizhakkedathu JN 2016 Acta Biomater View Researchers Basic research
Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway Krisinger MJ, Goebeler V, Lu Z, Meixner SC, Myles T, Pryzdial EL, Conway EM 2012 Blood View Researchers Basic research
Virus-Platelet Associations Pryzdial ELG, Lin BH, Sutherland MR 2017 Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update View Researchers Basic research
Serpin Phage Display: The Use of a T7 System to Probe Reactive Center Loop Libraries with Different Serine Proteinases de Souza LR, Scott BM, Bhakta V, Donkor DA, Perruzza DL, Sheffield WP 2018 Serpins: Methods and Protocols View Researchers Other
Systematic review of fondaparinux for heparin-induced thrombocytopenia: When there are no randomized controlled trials Linkins L, Hu G, Warkentin TE 2018 Res Pract Thromb Haemost View Researchers Clinical research
How we treat paroxysmal nocturnal hemoglobinuria: A consensus statement of the Canadian PNH Network and review of the national registry Patriquin CJ, Kiss T, Caplan S, Chin-Yee I, Grewal K, Grossman J, Larratt L, Marceau D, Nevill T, Sutherland DR, Wells RA, Leber B 2019 Eur J Haematol View Researchers Clinical research
A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss Sheffield WP, Eltringham-Smith LJ, Bhakta V 2018 BMC Biotechnol View Researchers Basic research
Evaluating the Clinical Effect of Female Blood Donors of Child-Bearing Age on Maternal and Neonatal Outcomes: A Cohort Study Chassé M, Tinmouth A, Goldman M, O'Brien SF, Hawken S, Murphy MSQ, Walker M, Sprague AE, Wilson K, van Walraven C, Fergusson DA 2019 Transfus Med Rev View Researchers Clinical research
Isoagglutinin-reduced immunoglobulin retains efficacy in mouse models of immune thrombocytopenia and rheumatoid arthritis and is less likely to cause intravenous immunoglobulin–associated hemolysis Cen SY, Branch DR 2020 Transfusion View Researchers Basic research
Anti-inflammatory activity of CD44 antibodies in murine immune thrombocytopenia is mediated by Fc? receptor inhibition Norris PAA, Kaur G, Khan R, Zhu G, Ni H, Lazarus AH 2021 Blood View Researchers Basic research
Daudi cell stroma: An alternative to dithiothreitol to resolve daratumumab interference in pretransfusion testing Tremblay T, Branch DR, Loubaki L 2020 Transfusion View Researchers New or improved product or process
Selection and in vitro and in vivo characterization of a Kunitz protease inhibitor domain of protease nexin 2 variant that inhibits factor XIa without inhibiting plasmin Eltringham-Smith LJ, Bhakta V, Sheffield WP 2021 J Biotechnol View Researchers Basic research
Five novel FY null alleles associated with typing discrepancies Vege S, Floch A, Lomas-Frances C, Clarke G, Westhoff CM 2021 Transfusion View Researchers Benchmarking and standard setting
Background incidence rates of hospitalisations and emergency department visits for thromboembolic and coagulation disorders in Ontario, Canada for COVID-19 vaccine safety assessment: a population-based retrospective observational study Nasreen S, Calzavara AJ, Sundaram ME, MacDonald SE, Righolt CH, Pai M, Field TS, Zhou LW, Wilson SE, Kwong JC 2021 BMJ Open View Researchers Clinical research
Plateletworks® as a Point-of-Care Test for ASA Non-Sensitivity Khan H, Jain S, Gallant RC, Syed MH, Zamzam A, Al-Omran M, Rand ML, Ni H, Abdin R, Qadura M 2021 J Pers Med View Researchers New or improved product or process
Sexual issues in people with haemophilia: Awareness and strategies for overcoming communication barriers Blamey G, Van Tassel B, Sagermann E, Stain AM, Waterhouse L, Iorio A 2022 Haemophilia View Researchers Ethical, legal and social implications research
Taking lessons from nature to improve cell therapy cryopreservation Acker J, William N, Coatham M 2023 Cell Gene Ther Insights View Researchers Basic research
Molecular Screening of Blood Donors for Babesia in Tyrol, Austria Bloch EM, Siller A, Tonnetti L, Drews SJ, Spencer BR, Hedges D, Mergenthal T, Weber-Schehl M, Astl M, Patel EU, Gaber M, Schennach H 2023 Transfus Med Hemother View Researchers Clinical research
Characteristics of VITT antibodies in patients vaccinated with Ad26.COV2.S Huynh A, Arnold DM, Michael JV, Clare R, Smith JW, Daka M, Ianosi-Irimie M, McKenzie SE, Kelton JG, Nazy I 2023 Blood Adv View Researchers Clinical research
Donor sex, pre-donation hemoglobin, and manufacturing affect CD71+ cells in red cell concentrates Li W, William N, Acker JP 2023 Transfusion View Researchers Basic research
How do we decide how representative our donors are for public health surveillance? O'Brien SF, Drews SJ, Lewin A, Russell A, Davison K, Goldman M, International Society for Blood Transfusion Transfusion Transmitted Infectious Disease Working Party Surveillance Risk Assessment Policy Sub-group 2022 Transfusion View Researchers Benchmarking and standard setting
GRADE guidance 35: update on rating imprecision for assessing contextualized certainty of evidence and making decisions Schünemann HJ, Neumann I, Hultcrantz M, Brignardello-Petersen R, Zeng L, Murad MH, Izcovich A, Morgano GP, Baldeh T, Santesso N, Cuello CG, Mbuagbaw L, Guyatt G, Wiercioch W, Piggott T, De Beer H, Vinceti M, Mathioudakis AG, Mayer MG, Mustafa R, Filippini T, Iorio A, Nieuwlaat R, Marcucci M, Coello PA, Bonovas S, Piovani D, Tomlinson G, Akl EA 2022 J Clin Epidemiol View Researchers Clinical research
Cold-stored platelets are effective in an in vitro model of massive transfusion protocol assessed by rotational thromboelastometry Zhao HQ, Serrano K, Culibrk B, Chen Z, Devine DV 2022 Transfusion View Researchers New or improved product or process
[Influence of Anticoagulants on Detection of ITP Platelet-Specific Autoantibodies and Relationship of Autoantibody Types with Glucocorticoid Efficacy] Chen Y, Ge J, Ruan M, Zhu L-Y, Zeng Q-S, Xia R-X, Ni H 2015 Zhongguo shi yan xue ye xue za zhi View Researchers Basic research
A platelet cover-up Arnold DM 2013 Blood View Researchers Other
Adoptive-Transfer Effects of Intravenous Immunoglobulin in Autoimmunity Lazarus AH 2010 J Clin Immunol View Researchers Basic research
Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis Lei X, Reheman A, Hou Y, Zhou H, Wang Y, Marshall AH, Liang C, Dai X, Li BX, Vanhoorelbeke K, Ni H 2014 Thromb Haemost View Researchers Basic research
Chemoenzymatic Synthesis of a Type 2 Blood Group A Tetrasaccharide and Development of High-throughput Assays Enables a Platform for Screening Blood Group Antigen-cleaving Enzymes Kwan DH, Ernst S, Kotzler MP, Withers SG 2015 Glycobiology View Researchers Basic research
Concentré de recherche: Comment se comportent les bactéries lors de la fabrication des plaquettes? Ramirez-Arcos S 2017 Blood.ca website View Researchers Basic research
Efficacy and safety of regenerative cell therapy for pulmonary arterial hypertension in animal models: a preclinical systematic review protocol Suen CM, Zhai A, Lalu MM, Welsh C, Levac BM, Fergusson D, McIntyre L, Stewart DJ 2016 Syst Rev View Researchers Basic research
Fc-independent phagocytosis: Implications for IVIG and other therapies in immune-mediated thrombocytopenia Li J, van der Wal DE, Zhu L, Vadasz B, Simpson EK, Li C, Webster ML, Zhu G, Lang S, Chen P, Zeng Q, Ni H 2013 Cardiovasc Hematol Disord Drug Targets View Researchers Other
Introduction to the special issue: Teaching healthcare operations research, part 2 Blake J 2017 INFORMS Transactions on Education View Researchers New or improved product or process
Low-dose decitabine promotes megakaryocyte maturation and platelet production in healthy controls and immune thrombocytopenia Zhou H, Hou Y, Liu X, Qiu J, Feng Q, Wang Y, Zhang X, Min Y, Shao L, Liu X, Li G, Li L, Yang L, Xu S, Ni H, Peng J, Hou M 2015 Thromb Haemost View Researchers Basic research
Microparticles as biomarkers of lung disease - enumeration in biological fluids using lipid bilayer microspheres McVey MJ, Spring C, Semple JW, Maishan M, Kuebler WM 2016 Am J Physiol Lung Cell Mol Physiol View Researchers Basic research
p38MAPK is involved in apoptosis development in apheresis platelet concentrates after riboflavin and ultraviolet light treatment Chen Z, Schubert P, Culibrk B, Devine DV 2014 Transfusion View Researchers Basic research
QSAR accelerated discovery of potent ice recrystallization inhibitors Briard JG, Fernandez M, De Luna P, Woo TK, Ben RN 2016 Sci Rep View Researchers Basic research
Reduction of thrombus size in murine models of thrombosis following administration of recombinant alpha1-proteinase inhibitor mutant proteins Sheffield WP, Eltringham-Smith LJ, Bhakta V, Gataiance S 2012 Thromb Haemost View Researchers Basic research
Riboflavin and ultraviolet light treatment of platelets triggers p38MAPK signaling: inhibition significantly improves in vitro platelet quality after pathogen reduction treatment Schubert P, Coupland D, Culibrk B, Goodrich RP, Devine DV 2013 Transfusion View Researchers Basic research
SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL Evren S, Ma XZ, Sakac D, Branch DR 2012 Exp Hematol View Researchers Basic research
Sustained expression of coagulation Factor IX by modified cord blood-derived mesenchymal stromal cells Dodd M, Marquez-Curtis L, Janowska-Wieczorek A, Hortelano G 2014 J Gene Med View Researchers Basic research
The procoagulant envelope virus surface: contribution to enhanced infection Pryzdial EL, Sutherland MR, Ruf W 2014 Thromb Res View Researchers Basic research
Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: induction of antibody-mediated immune suppression and prevention of severe clinical complications in a murine model Tiller H, Killie MK, Chen P, Eksteen M, Husebekk A, Skogen B, Kjeldsen-Kragh J, Ni H 2012 Transfusion View Researchers Basic research
Unexpected suppression of anti-Fya and prevention of hemolytic disease of the fetus and newborn after administration of Rh immune globulin Branch DR, Scofield TL, Moulds JJ, Swanson JL 2011 Transfusion View Researchers Basic research
Changes in minimum hemoglobin and interdonation interval: impact on donor hemoglobin and donation frequency Goldman M, Yi Q-L, Steed T, O'Brien SF 2019 Transfusion View Researchers New or improved product or process
The potential role of a turbidimetric heart-type fatty acid-binding protein assay to aid in the interpretation of persistently elevated, non-changing, cardiac troponin I concentrations Kavsak PA, Ainsworth C, Arnold DM, Scott T, Clark L, Ivica J, Mackett K, Whitlock R, Worster A 2018 Clin Biochem View Researchers Basic research