Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
The 14-3-3ζ–c-Src–integrin-?3 complex is vital for platelet activation Shen C, Liu M, Xu R, Wang G, Li J, Chen P, Ma W, Mwangi J, Lu Q, Duan Z, Zhang Z, Dahmani FZ, Mackeigan DT, Ni H, Lai R 2020 Blood View Researchers Basic research
Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): Study protocol for an international, multicenter, randomized open-label trial Bégin P, Callum J, Heddle N, Cook R, Zeller MP, Tinmouth A, Fergusson D, Cushing MM, Glesby MJ, Chassé M, Devine DV, Robitaille N, Bazin R, Shehata N, Finzi A, McGeer A, Scales D, Schwartz L, Turgeon AF, Zarychanski R, Daneman N, Carl R, Amorim L, Gabe C, Ellis M, Jamula E, Carruthers J, Duncan J, Lucier K, Armali C, Kron A, Modi D, Auclair M-C, Avram M, Arnold DM 2021 Trials View Researchers Clinical research
Establishment of Transfusion-Relevant Bacteria Reference Strains for Red Blood Cells Prax M, Spindler-Raffel E, McDonald CP, Bearne J, Satake M, Kozakai M, Rojo J, Hanschmann K-MO, Lambrecht B, Grundmann U, O’Flaherty N, Klimek A, Bekeredjian-Ding I, Gathof BS, Störmer M, Süßner S, Renke C, Lee C-k, Knabbe C, Vollmer T, Keil SD, Shipps ME, Wagner SJ, Jentsch U, Mpumlwana X, Cloutier M, Bringmann P, Lu T, Ramirez-Arcos S, Kou Y, Krut O, ISBT Transfusion-Transmitted Infectious Diseases Working Party SoB 2020 Vox Sang View Researchers New or improved product or process
In Vitro Characterization and Metabolomic Analysis of Cold-Stored Platelets Zhao HW, Serrano K, Stefanoni D, D’Alessandro A, Devine DV 2021 J Proteome Res View Researchers Basic research
Pathogen reduction of whole blood: Supplementing fibrinogen partly corrects clot formation in a massive transfusion model Arbaeen AF, Schubert P, Sheffield WP, Devine DV 2021 Transfusion View Researchers New or improved product or process
Transient loss of membrane integrity following intracellular ice formation in dimethyl sulfoxide-treated hepatocyte and endothelial cell monolayers William N, Acker JP 2020 Cryobiology View Researchers Basic research
Heparin-Induced Thrombocytopenia and Vaccine-Induced Immune Thrombotic Thrombocytopenia Antibodies: Fraternal-Not Identical-Twins Warkentin TE 2021 Thromb Haemost View Researchers Clinical research
Vaccine-induced immune thrombotic thrombocytopenia presenting with normal platelet count Page D, Zhu N, Sawler D, Sun HW, Turley E, Pai M, Wu C 2021 Res Pract Thromb Haemost View Researchers Clinical research
External qualification of the Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) models for octocog alfa using real patient data Chelle P, Hajducek D, Mahdi M, Young S, Iorio A, Silvertown J, Edginton A 2021 Res Pract Thromb Haemost View Researchers New or improved product or process
In Vitro Effect of Methamphetamine on Proliferation, Differentiation and Apoptosis of Adipose Tissue Stem Cells: In vitro Effect of Methamphetamine Anari L, Mehrabani D, Nasiri M, Zare S, Jamhiri I, Acker J 2022 J Pharm Sci View Researchers Basic research
Characterization of CD41(+) cells in the lymph node Dai L, Uehara M, Li X, LaBarre BA, Banouni N, Ichimura T, Lee-Sundlov MM, Kasinath V, Sullivan JA, Ni H, Barone F, Giannini S, Bahmani B, Sage PT, Patsopoulos NA, Tsokos GC, Bromberg JS, Hoffmeister K, Jiang L, Abdi R 2022 Front Immunol View Researchers Basic research
How do we forecast tomorrow's transfusion? Applying social science approaches to meet tomorrow's transfusion needs: Blood donors and donation Haw J, Holloway K, Goldman M 2023 Transfus Clin Biol View Researchers Ethical, legal & social implications research
Antigen copy number and antibody dose can determine the outcome of erythrocyte alloimmunization inducing either antibody-mediated immune suppression or enhancement in a murine model Wabnitz H, Cruz-Leal Y, Lazarus AH 2023 Transfusion View Researchers Basic research
A monoclonal antibody with anti-D–like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects Yu X, Menard M, Seabright G, Crispin M, Lazarus AH 2015 Transfusion View Researchers Basic research
Amelioration of Murine Passive Immune Thrombocytopenia by IVIg and a Therapeutic Monoclonal CD44 Antibody Does Not Require the Myd88 Signaling Pathway Crow AR, Yu H, Han D, Lazarus AH 2013 PLoS One View Researchers Basic research
CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia Guo L, Kapur R, Aslam R, Speck ER, Zufferey A, Zhao Y, Kim M, Lazarus AH, Ni H, Semple JW 2016 Blood View Researchers Basic research
Clinical Studies of Ex Vivo Expansion to Accelerate Engraftment After Umbilical Cord Blood Transplantation: A Systematic Review Kiernan J, Damien P, Monaghan M, Shorr R, McIntyre L, Fergusson D, Tinmouth A, Allan D 2016 Transfus Med Rev View Researchers Clinical research
Engineering biomaterials surfaces to modulate the host response Yu K, Mei Y, Hadjesfandiari N, Kizhakkedathu JN 2014 Colloids Surf B Biointerfaces View Researchers Basic research
Immunogenicity of murine mPEG-red blood cells and the risk of anti-PEG antibodies in human blood donors Le Y, Toyofuku WM, Scott MD 2017 Exp Hematol View Researchers Basic research
Influence of architecture of high molecular weight linear and branched polyglycerols on their biocompatibility and biodistribution Imran ul-haq M, Lai BF, Chapanian R, Kizhakkedathu JN 2012 Biomaterials View Researchers Basic research
IVIG regulates the survival of human but not mouse neutrophils Schneider C, Wicki S, Graeter S, Timcheva TM, Keller CW, Quast I, Leontyev D, Djoumerska-Alexieva IK, Kasermann F, Jakob SM, Peyta D, Branch D, Cummings J, Kaufmann T, Simon H, Von Gunten S 2017 Sci Rep View Researchers Basic research
Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets Zufferey A, Speck ER, Machlus KR, Aslam R, Guo L, McVey MJ, Kim M, Kapur R, Boilard E, Italiano JE, Jr., Semple JW 2017 Blood Adv View Researchers Basic research
Non-invasive spectroscopy of transfusable red blood cells stored inside sealed plastic blood-bags Buckley K, Atkins CG, Chen D, Schulze HG, Devine DV, Blades MW, Turner RFB 2016 Analyst View Researchers New or improved product or process
Platelet MicroRNAs: An Overview Dahiya N, Sarachana T, Vu L, Becker KG, Wood WH, Zhang Y, Atreya CD 2015 Transfus Med Rev View Researchers Basic research
Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond Xu XR, Zhang D, Oswald BE, Carrim N, Wang X, Hou Y, Zhang Q, Lavalle C, McKeown T, Marshall AH, Ni H 2016 Crit Rev Clin Lab Sci View Researchers Basic research
Progress in RNAi-mediated Molecular Therapy of Acute and Chronic Myeloid Leukemia Landry B, Valencia-Serna J, Gul-Uludag H, Jiang X, Janowska-Wieczorek A, Brandwein J, Uludag H 2015 Mol Ther Nucleic Acids View Researchers Other
Red blood cell membrane water permeability increases with length of ex vivo storage Alshalani A, Acker JP 2017 Cryobiology View Researchers Basic research
Residual risk of bacterial contamination of platelets: six years of experience with sterility testing Ramirez-Arcos S, DiFranco C, McIntyre T, Goldman M 2017 Transfusion View Researchers New or improved product or process
Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa Donkor DA, Bhakta V, Eltringham-Smith LJ, Stafford AR, Weitz JI, Sheffield WP 2017 Sci Rep View Researchers Basic research
The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand Boyle AJ, Roddick LA, Bhakta V, Lambourne MD, Junop MS, Liaw PC, Weitz JI, Sheffield WP 2013 BMC Biochem View Researchers Basic research
The mechanism and modulation of complement activation on polymer grafted cells Leung VL, Kizhakkedathu JN 2016 Acta Biomater View Researchers Basic research
Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway Krisinger MJ, Goebeler V, Lu Z, Meixner SC, Myles T, Pryzdial EL, Conway EM 2012 Blood View Researchers Basic research
Virus-Platelet Associations Pryzdial ELG, Lin BH, Sutherland MR 2017 Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update View Researchers Basic research
Serpin Phage Display: The Use of a T7 System to Probe Reactive Center Loop Libraries with Different Serine Proteinases de Souza LR, Scott BM, Bhakta V, Donkor DA, Perruzza DL, Sheffield WP 2018 Serpins: Methods and Protocols View Researchers Other
Systematic review of fondaparinux for heparin-induced thrombocytopenia: When there are no randomized controlled trials Linkins L, Hu G, Warkentin TE 2018 Res Pract Thromb Haemost View Researchers Clinical research
How we treat paroxysmal nocturnal hemoglobinuria: A consensus statement of the Canadian PNH Network and review of the national registry Patriquin CJ, Kiss T, Caplan S, Chin-Yee I, Grewal K, Grossman J, Larratt L, Marceau D, Nevill T, Sutherland DR, Wells RA, Leber B 2019 Eur J Haematol View Researchers Clinical research
A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss Sheffield WP, Eltringham-Smith LJ, Bhakta V 2018 BMC Biotechnol View Researchers Basic research
Evaluating the Clinical Effect of Female Blood Donors of Child-Bearing Age on Maternal and Neonatal Outcomes: A Cohort Study Chassé M, Tinmouth A, Goldman M, O'Brien SF, Hawken S, Murphy MSQ, Walker M, Sprague AE, Wilson K, van Walraven C, Fergusson DA 2019 Transfus Med Rev View Researchers Clinical research
Isoagglutinin-reduced immunoglobulin retains efficacy in mouse models of immune thrombocytopenia and rheumatoid arthritis and is less likely to cause intravenous immunoglobulin–associated hemolysis Cen SY, Branch DR 2020 Transfusion View Researchers Basic research
Anti-inflammatory activity of CD44 antibodies in murine immune thrombocytopenia is mediated by Fc? receptor inhibition Norris PAA, Kaur G, Khan R, Zhu G, Ni H, Lazarus AH 2021 Blood View Researchers Basic research
Daudi cell stroma: An alternative to dithiothreitol to resolve daratumumab interference in pretransfusion testing Tremblay T, Branch DR, Loubaki L 2020 Transfusion View Researchers New or improved product or process
Selection and in vitro and in vivo characterization of a Kunitz protease inhibitor domain of protease nexin 2 variant that inhibits factor XIa without inhibiting plasmin Eltringham-Smith LJ, Bhakta V, Sheffield WP 2021 J Biotechnol View Researchers Basic research
Five novel FY null alleles associated with typing discrepancies Vege S, Floch A, Lomas-Frances C, Clarke G, Westhoff CM 2021 Transfusion View Researchers Benchmarking and standard setting
Background incidence rates of hospitalisations and emergency department visits for thromboembolic and coagulation disorders in Ontario, Canada for COVID-19 vaccine safety assessment: a population-based retrospective observational study Nasreen S, Calzavara AJ, Sundaram ME, MacDonald SE, Righolt CH, Pai M, Field TS, Zhou LW, Wilson SE, Kwong JC 2021 BMJ Open View Researchers Clinical research
Plateletworks® as a Point-of-Care Test for ASA Non-Sensitivity Khan H, Jain S, Gallant RC, Syed MH, Zamzam A, Al-Omran M, Rand ML, Ni H, Abdin R, Qadura M 2021 J Pers Med View Researchers New or improved product or process
Sexual issues in people with haemophilia: Awareness and strategies for overcoming communication barriers Blamey G, Van Tassel B, Sagermann E, Stain AM, Waterhouse L, Iorio A 2022 Haemophilia View Researchers Ethical, legal and social implications research
Taking lessons from nature to improve cell therapy cryopreservation Acker J, William N, Coatham M 2023 Cell Gene Ther Insights View Researchers Basic research
Molecular Screening of Blood Donors for Babesia in Tyrol, Austria Bloch EM, Siller A, Tonnetti L, Drews SJ, Spencer BR, Hedges D, Mergenthal T, Weber-Schehl M, Astl M, Patel EU, Gaber M, Schennach H 2023 Transfus Med Hemother View Researchers Clinical research
Characteristics of VITT antibodies in patients vaccinated with Ad26.COV2.S Huynh A, Arnold DM, Michael JV, Clare R, Smith JW, Daka M, Ianosi-Irimie M, McKenzie SE, Kelton JG, Nazy I 2023 Blood Adv View Researchers Clinical research
Donor sex, pre-donation hemoglobin, and manufacturing affect CD71+ cells in red cell concentrates Li W, William N, Acker JP 2023 Transfusion View Researchers Basic research