Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Bacterial neuraminidase-mediated erythrocyte desialylation provokes cell surface aminophospholipid exposure Qadri SM, Donkor DA, Nazy I, Branch DR, Sheffield WP 2018 Eur J Haematol View Researchers Basic research
Impact of osteoblast maturation on their paracrine growth enhancing activity on cord blood progenitors Alsheikh M, Abu?Khader A, Michalicka M, Pasha R, Pineault N 2017 Eur J Haematol View Researchers Basic research
How we treat paroxysmal nocturnal hemoglobinuria: A consensus statement of the Canadian PNH Network and review of the national registry Patriquin CJ, Kiss T, Caplan S, Chin-Yee I, Grewal K, Grossman J, Larratt L, Marceau D, Nevill T, Sutherland DR, Wells RA, Leber B 2019 Eur J Haematol View Researchers Clinical research
Prophylaxis use of clotting factor replacement products in people with non-severe haemophilia: A review of the literature Iorio A, Königs C, Reding MT, Rotellini D, Skinner MW, Mancuso ME, Berntorp E 2023 Haemophilia View Health care providers Clinical research
What should men living with severe haemophilia need to know? The perspectives of Canadian haemophilia health care providers Lane S, Arnold E, Webert KE, Chan A, Walker I, Heddle NM 2013 Haemophilia View Health care providers Other
Past, present and future of haemophilia gene therapy: From vectors and transgenes to known and unknown outcomes Pierce GF, Iorio A 2018 Haemophilia View Health care providers New or improved product or process
Factor product utilization and health outcomes in patients with haemophilia A and B on extended half-life concentrates: A Canadian observational study of real-world outcomes Sun H, Yang M, Poon M-C, Lee A, Robinson KS, Sholzberg M, Wu J, Iorio A, Blanchette V, Carcao M, Klaassen RJ, Jackson S 2021 Haemophilia View Researchers Clinical research
Switching to extended half-life products in Canada - preliminary data Keepanasseril A, Stoffman J, Bouskill V, Carcao M, Iorio A, Jackson S 2017 Haemophilia View Health care providers Clinical research
Test-retest properties of the Patient Reported Outcomes, Burdens and Experiences (PROBE) questionnaire and its constituent domains Chai-Adisaksopha C, Skinner MW, Curtis R, Frick N, Nichol MB, Noone D, O'Mahony B, Page D, Stonebraker J, Thabane L, Crowther MA, Iorio A 2019 Haemophilia View Researchers Clinical research
Treatment decision-making among Canadian youth with severe haemophilia: a qualitative approach Lane SJ, Walker I, Chan AK, Heddle NM, Poon MC, Minuk L, Jardine L, Arnold E, Sholapur N, Webert KE 2015 Haemophilia View Health care providers Clinical research
Converting factor and nonfactor usage into a single metric to facilitate benchmarking the resources consumed for haemophilia care across jurisdictions and over time Stonebraker JS, O'Mahony B, Noone D, Iorio A 2021 Haemophilia View Researchers Benchmarking and standard setting
Evaluation of the sexual health in people living with hemophilia Germini F, Chai-Adisaksopha C, Pete D, Curtis R, Frick N, Nichol MB, Noone D, O'Mahony B, Page D, Stonebraker JS, Thabane L, Crowther MA, Skinner MW, Iorio A 2021 Haemophilia View Researchers Clinical research
The importance of haemophilia treatment centre administrators in patient care Almonte T, Decker K, Seroski W, Walker I, Webert K, Bos C, Strike K, Waterhouse L, Goldsmith R, Chan AK 2012 Haemophilia View Health care providers Other
Challenges and key lessons from the design and implementation of an international haemophilia registry supported by a pharmaceutical company Hay CRM, Shima M, Makris M, Jiménez-Yuste V, Oldenburg J, Fischer K, Iorio A, Skinner MW, Santagostino E, von Mackensen S, Kessler CM 2020 Haemophilia View Researchers Clinical research
Rate and appropriateness of polypharmacy in older patients with hemophilia compared with age-matched controls Mannucci PM, Nobili A, Marchesini E, Oliovecchio E, Cortesi L, Coppola A, Santagostino E, Radossi P, Castaman G, Valdrè L, Santoro C, Tagliaferri A, Ettorre C, Zanon E, Barillari G, Cantori I, Caimi TM, Sottilotta G, Peyvandi F, Iorio A 2018 Haemophilia View Health care providers Clinical research
Exploring some intersections between pharmacokinetics, factor VIII measurement and human morphometrics - impact of recent advances in haemophilia study design on our understanding of optimal haemophilia treatment Iorio A, Edginton AN 2017 Haemophilia View Researchers Clinical research
Point of care ultrasound in haemophilia: Building a strong foundation for clinical implementation Lawson W, Uy M, Strike K, Iorio A, Stein N, Koziol L, Chan A 2017 Haemophilia View Health care providers Clinical research
Emicizumab state-of-the-art update Mahlangu J, Iorio A, Kenet G 2022 Haemophilia View Health care providers Clinical research
Switching from standard to extended half-life FVIII prophylaxis in haemophilia A: Comparison of factor product use, bleed rates and pharmacokinetics Nummi V, Lehtinen AE, Iorio A, Szanto T, Lassila R 2022 Haemophilia View Researchers Clinical research
Core outcome set for gene therapy in haemophilia: Results of the coreHEM multistakeholder project Iorio A, Skinner MW, Clearfield E, Messner D, Pierce GF, Witkop M, Tunis S 2018 Haemophilia View Health care providers Clinical research
Comparison of single subject and population-based pharmacokinetics for optimizing prophylaxis with simoctocog alfa in patients with haemophilia A Astermark J, Olsson A, Chelle P, Täckström K, Walger M, Magnusson M, Iorio A 2021 Haemophilia View Researchers Clinical research
Comorbidities in persons with haemophilia aged 60 years or more compared with age-matched people from the general population Marchesini E, Oliovecchio E, Coppola A, Santagostino E, Radossi P, Castaman G, Valdre L, Santoro C, Tagliaferri A, Ettorre C, Zanon E, Barillari G, Cantori I, Caimi TM, Sottilotta G, Iorio A, Mannucci PM 2018 Haemophilia View Health care providers Clinical research
A brief survey of clinicians' perceptions of parent preferences for involvement in obstetrical and perinatal management decisions in haemophilia Lucier KJ, Movilla RV, Parvizian MK, Siddiqui R, Gabriele EH, Bourque M, MacIsaac J, Moorehead PC, Chan AK, Heddle NM, Lane SJ 2018 Haemophilia View Health care providers Clinical research
Understanding stakeholder important outcomes and perceptions of equity, acceptability and feasibility of a care model for haemophilia management in the US: a qualitative study Lane SJ, Sholapur NS, Yeung CH, Iorio A, Heddle NM, Sholzberg M, Pai M 2016 Haemophilia View Health care providers Other
Target plasma factor levels for personalized treatment in haemophilia: a Delphi consensus statement Iorio A, Iserman E, Blanchette V, Dolan G, Escuriola Ettingshausen C, Hermans C, Negrier C, Oldenburg J, Reininger A, Rodriguez-Merchan C, Spannagl M, Valentino LA, Young G, Steinitz-Trost KN, Gringeri A 2017 Haemophilia View Health care providers Clinical research
A systematic review of definitions and reporting of bleeding outcome measures in haemophilia Chai-Adisaksopha C, Hillis C, Thabane L, Iorio A 2015 Haemophilia View Health care providers Clinical research
Patterns of joint damage in severe haemophilia A treated with prophylaxis Goren R, Pullenayegum E, Blanchette VS, Dover S, Carcao M, Israels SJ, Chan A, Rivard GE, Steele M, Cloutier S, Klaassen RJ, Sinha R, Price VE, Laferriere N, Paradis E, Wu JK, Feldman BM 2021 Haemophilia View Health care providers Clinical research
First analysis of 10-year trends in national factor concentrates usage in haemophilia: data from CHARMS, the Canadian Hemophilia Assessment and Resource Management System Traore AN, Chan AKC, Webert KE, Heddle N, Ritchie B, St-Louis J, Teitel J, Lillicrap D, Iorio A, Walker I 2014 Haemophilia View Health care providers Clinical research
Sexual issues in people with haemophilia: Awareness and strategies for overcoming communication barriers Blamey G, Van Tassel B, Sagermann E, Stain AM, Waterhouse L, Iorio A 2022 Haemophilia View Researchers Ethical, legal and social implications research
What should men living with haemophilia need to know? The perspectives of Canadian men with haemophilia Arnold E, Lane S, Webert KE, Chan A, Walker I, Tufts J, Rubin S, Poon MC, Heddle NM 2014 Haemophilia View Health care providers Other
Immunogenicity, efficacy and safety of Nuwiq® (human-cl rhFVIII) in previously untreated patients with severe haemophilia A-Interim results from the NuProtect Study Liesner RJ, Abashidze M, Aleinikova O, Altisent C, Belletrutti MJ, Borel-Derlon A, Carcao M, Chambost H, Chan AKC, Dubey L, Ducore J, Fouzia NA, Gattens M, Gruel Y, Guillet B, Kavardakova N, El Khorassani M, Klukowska A, Lambert T, Lohade S, Sigaud M, Turea V, Wu JKM, Vdovin V, Pavlova A, Jansen M, Belyanskaya L, Walter O, Knaub S, Neufeld EJ 2017 Haemophilia View Researchers Clinical research
A case of vertical transmission of Chagas Disease contracted via blood transfusion in Canada Fearon MA, Scalia V, Huang M, Dines I, Ndao M 2013 Can J Infect Dis Med Microbiol View Health care providers Clinical research
Comparison of bacterial attachment to platelet bags with and without preconditioning with plasma Loza-Correa M, Kalab M, Yi QL, Eltringham?Smith L, Sheffield W, Ramirez-Arcos S 2017 Vox Sang View Researchers Basic research
Deferral of males who had sex with other males Benjamin RJ, Bianco C, Goldman M, Seed CR, Yang H, Lee J, Keller AJ, Wendel S, Biagini S, Murray J, Devine DV, Zhu Y, Turek P, Moftah FM, Kullaste R, Pillonel J, Danic B, Bigey F, Folléa G, Seifried E, Mueller MM, Lin CK, Makroo RN, Grazzini G, Pupella S, Velati C, Tadokoro K, Bravo Lindoro A, D'Artote Gonzalez A, Giner VT, Flanagan P, Olaussen RW, Letowska M, Rosiek A, Poglod R, Zhiburt E, Mali P, Rozman P, Gulube S, Castro Izaguirre E, Ekermo B, Barnes SM, McLaughlin L, Eder AF, Panzer S, Reesink HW 2011 Vox Sang View Blood operators Benchmarking and standard setting
International Forum regarding practices related to donor haemoglobin and iron Goldman M, Magnussen K, Gorlin J, Lozano M, Speedy J, Keller A, Pink J, Leung JNS, Chu CCY, Lee CK, Faed J, Chay J, Tan HH, Teo D, Djoudi R, Woimant G, Fillet AM, Castrén J, Miflin G, Vandewalle GC, Compernolle V, Cardenas JM, Infanti L, Holbro A, Buser A, van den Hurk K, Yahalom VJ, Gendelman V, Shinhar E, Eder AF, Steele WR, O'Neill EM, Kamel H, Vassallo R, Delage G, Lebrun A, Robillard P, Germain M, Gandhi M, West KA, Klein HG 2016 Vox Sang View Blood operators Other
Mortality outcomes in patients transfused with fresher versus older red blood cells: a meta-analysis Chai-Adisaksopha C, Alexander PE, Guyatt G, Crowther MA, Heddle NM, Devereaux PJ, Ellis M, Roxby D, Sessler DI, Eikelboom JW 2017 Vox Sang View Health care providers Clinical research
The impact of donor ferritin testing on blood availability in Canada Blake JT, O'Brien SF, Goldman M 2022 Vox Sang View Blood operators New or improved product or process
Allowing blood donation from men who had sex with men more than 5 years ago: a model to evaluate the impact on transfusion safety in Canada Germain M, Robillard P, Delage G, Goldman M 2013 Vox Sang View Blood operators New or improved product or process
Bacterial survival and distribution during buffy coat platelet production Taha M, Kalab M, Yi QL, Maurer E, Jenkins C, Schubert P, Ramirez-Arcos S 2016 Vox Sang View Researchers New or improved product or process
Evaluation of a universal point-of-issue assay for bacterial detection in buffy coat platelet components Ramirez-Arcos S, Kou Y, Perkins H 2014 Vox Sang View Blood operators New or improved product or process
Blood donation and the global COVID-19 pandemic: areas for social science research Haw J, Holloway K, Masser B, Merz E-M, Thrope R 2020 Vox Sang View Researchers New or improved product or process
Themed issue – focusing on donor assessment, motivation and vigilance O’Brien SF, Ullum H, Seed CR 2021 Vox Sang View Researchers New or improved product or process
Challenging the 30-min rule for thawed plasma Ramirez-Arcos S, Howell A, Bearne J, Bhakta V, Bower L, Cardigan R, Girard M, Kou Y, McDonald C, Nolin M-È, Sawicka D, Sheffield W 2021 Vox Sang View Researchers Benchmarking and standard setting
Medication use in Canadian blood donors Goldman M, Miller O, O'Brien SF 2023 Vox Sang View Blood operators Clinical research
A multicentred study to validate a consensus bleeding assessment tool developed by the biomedical excellence for safer transfusion collaborative for use in patients with haematological malignancy Dyer C, Alquist CR, Cole-Sinclair M, Curnow E, Dunbar NM, Estcourt LJ, Kaufman R, Kutner JM, McCullough J, McQuilten Z, Potiphar L, Rioux-Masse B, Slichter S, Tinmouth A, Webert K, Yokoyama AP, Stanworth SJ 2018 Vox Sang View Health care providers Clinical research
Assessing the influence of component processing and donor characteristics on quality of red cell concentrates using quality control data Jordan A, Chen D, Yi QL, Kanias T, Gladwin MT, Acker JP 2016 Vox Sang View Researchers Basic research
Donor motivation in Xi'an, China: comparison with Canadian donors O'Brien SF, Shao ZJ, Osmond L, Yi QL, Li CY, An QX 2012 Vox Sang View Blood operators Other
Measures to prevent transfusion-related acute lung injury (TRALI) Reesink HW, Lee J, Keller A, Dennington P, Pink J, Holdsworth R, Schennach H, Goldman M, Petraszko T, Sun J, Meng Y, Qian K, Rehacek V, Turek P, Krusius T, Juvonen E, Tiberghien P, Legrand D, Semana G, Muller JY, Bux J, Reil A, Lin CK, Daly H, McSweeney E, Porretti L, Greppi N, Rebulla P, Okazaki H, Sanchez-Guerrero SA, Baptista-Gonzalez HA, Martinez-Murillo C, Guerra-Marquez A, Rodriguez-Moyado H, Middelburg RA, Wiersum-Osselton JC, Brand A, van Tilburg C, Dinesh D, Dagger J, Dunn P, Brojer E, Letowska M, Maslanka K, Lachert E, Uhrynowska M, Zhiburt E, Palfi M, Berlin G, Frey BM, Puig Rovira L, Muniz-Diaz E, Castro E, Chapman C, Green A, Massey E, Win N, Williamson L, Silliman CC, Chaffin DJ, Ambruso DR, Blumberg N, Tomasulo P, Land KJ, Norris PJ, Illoh OC, Davey RJ, Benjamin RJ, Eder AF, McLaughlin L, Kleinman S, Panzer S 2012 Vox Sang View Blood operators Benchmarking and standard setting
Stability of coagulation protein activities in single units or pools of cryoprecipitate during storage at 20–24°C for up to 24 h Sheffield WP, Bhakta V, Jenkins C 2016 Vox Sang View Blood operators New or improved product or process
ABO blood group and COVID-19: a review on behalf of the ISBT COVID-19 working group Goel R, Bloch EM, Pirenne F, Al-Riyami AZ, Crowe E, Dau L, Land K, Townsend M, Jecko T, Rahimi-Levene N, Patidar G, Josephson CD, Arora S, Vermeulen M, Vrielink H, Montemayor C, Oreh A, Hindawi S, van den Berg K, Serrano K, So – Osman C, Wood E, Devine DV, Spitalnik SL, the ISBT COVID-19 Working Group 2021 Vox Sang View Researchers Clinical research