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Transplantation

Improving a quality test for cord blood samples


Thursday, February 27, 2020 Dr. Geraldine Walsh

Cord blood — the blood left in the umbilical cord after a baby is born — is a rich and important source of stem cells for transplantation. Stem cell transplants are used to treat more than 80 diseases and disorders, including blood cell cancers such as leukemia. The national Canadian Blood Services’ Cord Blood Bank collects, processes and freezes cord blood units. These units are available to any patient worldwide who needs a stem cell transplant and finds a match in the bank. 

Recent research conducted by the Centre for Innovation and Canadian Blood Services Cord Blood Bank and stem cell manufacturing sought to improve pre-transplant quality tests of thawed cord blood samples. These tests are important as they are used to make decisions about whether the cord blood unit will be suitable for transplantation.

The study, “Overcoming the deceptively low viability of CD45+ cells in thawed cord blood unit segments” was published in November 2019 in Vox Sanguinis.  

The study findings suggest ways to improve the quality test procedure so that the results produced better reflect the quality of the cord blood unit to be transplanted. This could increase the number of cord blood units that can be released for transplantation by reducing the number of cord blood units that fail quality tests.

To learn more about the study, read our latest Research Unit.


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Friday, July 19, 2019
Obinna Okwelume

Dr. Nicolas Pineault speaks about his passion for stem cell research, and the exciting new projects he’s currently engaged in.


Wednesday, May 11, 2016
Jenny Ryan

Dr. Pineault and his team are working on a cellular therapy to improve engraftment (the process through which new blood-forming cells start to develop in the patient) following cord blood stem cell transplantation.


Wednesday, July 12, 2017
Jenny Ryan

July marks Cord Blood Awareness Month in certain places around the world. In homage to this important campaign we collected a few related stories from the RED archives and share a bit more information about why Cord Blood matters. Cord blood stem cells can be used in the treatment of more than 80...

Nominations now open for the 2020 Canadian Blood Services Lifetime Achievement Award


Tuesday, February 18, 2020 Dr. Geraldine Walsh

Recipients of the Canadian Blood Services Lifetime Achievement Award are individuals whose landmark contributions are recognized as both extraordinary and world class in the field of transfusion or transplantation medicine, stem cell or cord blood research in Canada and/or abroad.

Who can be nominated?

To be nominated for the Canadian Blood Services Lifetime Achievement Award, an individual must have contributed significantly to improving the safety and/or quality of blood, blood products, stem cells and/or cord blood or has made noteworthy improvements or advances in transfusion or transplantation medicine practice. Their record of publication should be of significance and their professional reputation should be aligned with the goals and reputation of Canadian Blood Services, reflecting a quality culture driven by excellence.

Be inspired by past recipients

Typically, there is only one recipient of the Canadian Blood Services Lifetime Achievement Award each year, but in 2019 two outstanding innovators were recognized. Dr. Donna Wall was honoured for her medical career spanning almost 40 years during which she made significant contributions to the evolution of blood and marrow transplantation across North America. Transplant physician and scientist Dr. Harold Atkins was honoured for his career dedicated to discovering innovative methods for stem cell transplantation.

The 2020 Lifetime Achievement Award will be presented on September 21, 2020 in Ottawa at the annual national Honouring Canada’s Lifeline event where Canadian Blood Services honours donors, volunteers, peer recruiters and partners for their outstanding dedication and achievements.

To learn about past recipients of the Canadian Blood Services Lifetime Achievement Award, and other awardees at the Honouring Canada's Lifeline annual ceremony, click here.

Nomination requirements
  • Provide a short introduction and summary in 150 words or less of the nominee’s contribution to improving the safety and/or quality of blood, blood products or stem cells, or contribution to advances in transfusion medicine practice
  • Present a brief biography including academic, research, clinical and administrative positions, awards or recognitions
  • Outline how the work of the nominee is set apart from the work of others in the field
  • Provide a nominee’s full current curriculum vitae and contact information for the nominee including full name, mailing address, telephone number(s) and email address
  • Provide name and contact information for the nominator(s)

Candidates should be unaware that they have been nominated for this award.

Process for nominations

To nominate an individual for the Canadian Blood Services Lifetime Achievement Award, please submit in writing to:

Canadian Blood Services Lifetime Achievement Award Nominating Committee
c/o Dr. Isra Levy, Vice President, Medical Affairs and Innovation
Canadian Blood Services
1800 Alta Vista Drive

Ottawa, Ontario K1G 4J5

isra.levy@blood.ca

Nominations must be received by May 19, 2020.

More information

The Canadian Blood Services Lifetime Achievement Award came into existence in 2002. To date, the Canadian Blood Services Board of Directors has selected the following individuals for this prestigious award:

  • Dr. John Bowman, 2002
  • Ms. Marie Cutbush Crookston, 2002
  • Dr. Morris A. Blajchman, 2003
  • Dr. Peter Pinkerton, 2004
  • Dr. John Freedman, 2006
  • Dr. Hans Messner, 2007
  • Mr. Justice Horace Krever, 2008
  • Dr. Gail Rock, 2009
  • Dr. Victor Blanchette, 2010
  • Dr. Allen Eaves and Dr. Connie Eaves, 2011
  • Dr. Celso Bianco, 2012
  • The Canadian Hemophilia Society, 2013
  • Dr. John Dossetor, 2013
  • Dr. Gershon Growe, 2014
  • Dr. Bruce McManus, 2015
  • Dr. David Lillicrap, 2016
  • Nancy Heddle, Leah Hollins 2017
  • André Picard, 2018
  • Dr. Harold Atkins and Dr. Donna Wall, 2019

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Friday, September 27, 2019
Catherine Lewis

With a medical career spanning almost 40 years, Dr. Donna Wall has made significant contributions to the evolution of blood and marrow transplantation across North America. After completing paediatric and paediatric hematology/oncology training in the U.S., Dr. Wall went on to establish blood and...


Thursday, September 26, 2019
Catherine Lewis

With a focus on improving the lives of patients living with autoimmune diseases, transplant physician and scientist Dr. Harold Atkins has dedicated his career to discovering innovative methods for stem cell transplantation. In the late 1990s, Dr. Atkins and neurologist Dr. Mark Freedman proposed a...


Monday, May 13, 2019
Obinna Okwelume

Recipients of the Canadian Blood Services Lifetime Achievement Award are individuals whose landmark contributions are recognized as both extraordinary and world class in the field of transfusion or transplantation medicine, stem cell or cord blood research in Canada and/or abroad.

Highlights from the 2019 Critical Care Canada Forum


Thursday, February 06, 2020 Jenny Ryan

The 2019 Critical Care Canada Forum (CCCF) took place in Toronto Nov. 10-13. This year marked the fifth annual Deceased Organ Donation Symposium, a two-day symposium held during CCCF that promotes scientific research and discussion about organ donation and transplantation and its application to critical care practice. 

Presented by Canadian Blood Services, Trillium Gift of Life and the Canadian Donation and Transplantation Research Program, this year’s event did not disappoint. Presentations from this session were recorded and can be found on Canadian Blood Services’ professional education website.

Highlights

Opt-out (presumed/deemed consent) — In April 2019, Nova Scotia became the first jurisdiction in Canada to pass opt-out legislation, designed to increase organ and tissue donation. To better understand the real-world implications and impact of this consent model, attendees heard from Phil Walton, the United Kingdom’s deemed consent project lead.  His message for Canadian jurisdictions considering this legislation change was to ensure the right people were around the table and that true collaboration among these groups was employed – legislators, regulators, faith groups, organ donation organizations, patients, families, as well as media and ethics experts. 

 

For health care professionals, the legislation should not change end-of-life conversations with families. The patient and unique life-saving opportunity at hand should remain the focus of every family discussion. The legislation is simply a tool to help the family support a decision. 

 

Randall Tressider presents at Canadian Critical Care Forum in 2019, alongside a photo of his deceased wife Shelly Sarwal

Medical assistance in dying and organ donation — The legalization of medical assistance in dying (MAID) in Canada has led to requests for donation after circulatory determination of death from patients who are conscious and competent. Randy Tresidder, whose wife Dr. Shelly Sarwal was the first person to undergo MAID and organ donation in Nova Scotia, shared his story. His honesty about the personal conflicts he experienced in order to accept and wholly support his wife’s decision to become an organ and tissue donor brought great insight to a sensitive subject.

The incredible story of Dr. Sarwal is captured in the documentary film Her Last Project, which attendees also had the opportunity to view during the conference.

Non-Perfused Organ Donation – Dr. Marcelo Cypel, from the Toronto Lung Transplant Program, described an innovative technique that is being used to expand the donor – non-perfused organ donation (NPOD). 

At select hospitals in Ontario, patients who were unable to be resuscitated after an unexpected death, such as a cardiac arrest, are referred to the organ donation organization for initial suitability screening.   Potential NPOD donors have their lungs inflated with oxygen for up to three hours; the timeframe permitted for family approach and consent, deployment of the recovery teams, and lung recovery to take place.  After recovery, the lungs are placed on an ex-vivo lung perfusion machine to evaluate the quality of their function prior to transplantation. 

Dr. Cypel shared that this type of donation had resulted in five transplants to date.  One recipient was a surprise guest at the Symposium.  Eric Celentano’s gratitude for a second chance at life reminded attendees why this work is so important. 

Recordings from all of the Deceased Organ Donation Symposium sessions are posted on the Professional Education website, available here.

Check out the gallery for more photos, including one of the inaugural meeting to begin development of a national pediatric donation and transplantation strategy focused to optimizing neonatal and pediatric donation, organ utilization and transplant outcomes. The meeting included more than 30 participants from pediatrics, critical care, donation, transplantation, research as well as donor families and Canadian Blood Services. Meagan Mahoney, a pediatric intensivist from Calgary; Laurie Lee, a pediatric nurse practitioner from Calgary; and Lee James from Canadian Blood Services’ Deceased Donation team will lead and support a steering committee to advance this important work.

Did you miss the 2018 event? Videos from the 2018 Deceased Donation Symposium at CCCF are available here.


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Tuesday, November 06, 2018
Jenny Ryan

The Critical Care Canada Forum (CCCF) takes place this week in Toronto. The annual event is attended by hundreds of health professionals working in critical care, primarily physicians. A key event within the Forum is an unopposed plenary on brain death determination, to be held on Wednesday, November 7th.


Tuesday, October 08, 2019
Jenny Ryan

This year marks the fifth annual Deceased Organ Donation Symposium at the Critical Care Canada Forum in Toronto. This two-day symposium held Nov. 11–12, 2019 promotes scientific research in organ donation and transplantation and its application to critical care practice.


Wednesday, December 20, 2017
Jenny Ryan

Canadian partners bring experts together for two-day Deceased Donation Symposium as part of CCCF

Top 5 blog posts of 2019


Tuesday, January 07, 2020 Catherine Lewis

Welcome to 2020! Take a look back with us by checking out the five most visited R.E.D. blog posts in 2019. 

 

Group of blood donors

1. The ABCs of ABO blood types

In the early days of transfusion medicine, doctors gave patients all sorts of different fluids, including blood or milk from animals. Success varied, and the results were often disastrous—even when they used human blood. It wasn’t until the start of the 20th century that physicians learned the ABCs of the ABO blood types and finally understood how to give a successful transfusion. Read more >>

 

 

 

 

iron

2. Ferritin findings: investigating iron and impacts on donors

The health and well-being of our donors is a top priority at Canadian Blood Services. Health screening, education and donor testing help to ensure donors are healthy enough to give and that their gift doesn’t cause harm to themselves or to patients. If a problem is detected, we let donors know and advise to them to take action. Read more >>

 

3. Dr. Chantale Pambrun explains the importance of iron wellness

Iron is an essential element for producing hemoglobin (the molecule that helps transport oxygen around your body). Back in 2017, we made changes to donor eligibility based on new information our researchers learned about mitigating iron deficiency in blood donors.

In this post, Centre for Innovation director Dr. Chantale Pambrun, who was at the time medical consultant, donor and clinical services with Canadian Blood Services, explains why we made changes, and provides some more information about why donor iron wellness is important. Read more >>

 

Nathaly, a mother who donated cord blood, holds her baby and toddler.

4. Cord blood matters - take time to learn more

Cord blood stem cells can be used in the treatment of more than 80 different diseases and disorders. By donating their baby’s cord blood, parents have the power to help patients living with diseases such as leukemia, lymphoma, aplastic anemia, and sickle cell disease. Researchers continue to explore the possibilities of using cord blood in many other treatments.

At any given time, there are hundreds of Canadian patients searching for an unrelated stem cell donor. Cord blood might just be the chance they need. Read more >>

 

5. Why do scientists use mice in medical research? 

Mice fill a special and important role in medical research. Like humans, mice are mammals, and their bodies undergo many similar processes, such as ageing, and have similar immune responses to infection and disease. Their hormone (endocrine) systems are a lot like ours, too. They’re also one of the first species — along with humans — to have had their complete genome sequenced. From this, we’ve learned they share approximately 80 per cent of their genes with us. Read more >>


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Tuesday, January 01, 2019
Jenny Ryan

As the year comes to a close and 2019 is set to begin, we take a moment to reflect on the 2018 articles that were among the most popular.


Wednesday, December 27, 2017
Jenny Ryan

It's hard to believe that 2017 is almost over. As we prepare for 2018, we take a look back on our most-read research, education and discovery stories from the past year. #5 Encouraging meaningful careers in STEM – Part 1 Image To encourage more young people to consider careers in science, technology...


Thursday, October 31, 2019
Catherine Lewis

Drinking the blood of the young, and thereby somehow capturing their youth, is a common literary trope. The ghoulish notion speaks to our cultural fascination with youth, but also to our dread of aging. There’s no evidence-based therapy using the blood of young people to counteract or prevent the...

Dr. Donald Branch honoured by AABB for his career achievements


Thursday, November 07, 2019 Catherine Lewis

Dr. Donald Branch’s career shows a scientist driven by intellectual curiosity. From Gila monster venom to crocodile blood, from HIV to Ebola to huge discoveries improving outcomes for transfusion and transplantation patients, he pursues scientific questions and embraces all the twists and turns that path of inquiry may take.  

“There’s always something new that keeps the interest going,” he says. “It’s pretty hard to figure out nature — it has a way of throwing a wrench in things just when you think you have an answer. Then you have to keep looking. There’s always a new angle, a new hypothesis, that keeps you from getting bored.” 

Last month, Dr. Branch, a scientist at Canadian Blood Services’ Centre for Innovation and professor at the University of Toronto, received a prestigious international award honouring his more than 40 years of major contributions to transfusion medicine and hematology.  

At this year’s annual meeting of AABB, an international organization representing people and institutions involved in transfusion medicine and cellular therapies, Dr. Branch received the Tibor Greenwalt Memorial Award. It’s his third award from AABB, but he says he isn’t in it for the accolades.  

“As a scientist, we don’t do our work thinking we’re going to get any awards. I do my science because I like it. It’s fun, interesting and exciting at times; and you get to think of new questions about what is important in biological sciences and how things work,” he says.  

“It’s nice to get an award, because it says what you’ve been doing for fun these last 40 years has paid off — people have found value in it. You have to have a thick skin in research. You have to be able to accept rejection and criticism, especially when you’re writing grants and papers. The work itself is interesting and exciting, but trying to advance the field can be difficult. When you actually get an award for something you’ve done, it’s meaningful because it represents years of hard work and overcoming some of the criticisms and roadblocks along the way.”  

Dr. Branch’s proudest accomplishment is being the first scientist to describe mixed hematopoietic chimerism, a state where after a bone marrow transplant both the recipient and donor’s cells exist together harmoniously in the blood. Published in 1982, Dr. Branch’s finding has been confirmed and generated more than 1200 related publications. Where there is mixed hematopoietic chimerism, there is little if any graft-versus-host disease, and this fact has led other scientists to explore this phenomenon for recipients of other types of transplants, such as hearts, livers, lungs, and kidneys. Introducing mixed hematopoietic chimerism into transplant recipients may lead to them not needing anti-rejection medication.  

“The general thinking at the time was that following bone marrow transplantation where myeloablation (a severe reduction in the ability of a patient’s bone marrow to produce new blood cells) was the protocol, if you begin to see the blood cells increasing in population, you’ve obtained engraftment of the donor stem cells. I found this wasn’t necessarily true. You could have the patient’s own stem cells come back and repopulate the patient, sometimes with no donor cells detectable for long periods of time; so, more genetic testing needed to be done to determine which cells, the patient’s or the donor’s, or both were coming back. This finding was something very new; this was the first time it had been reported,” he says.  

What’s next for Dr. Branch? He has many projects on the go, including one investigating whether HIV/AIDS could be a neuropeptide disease, and another looking at a little-understood phenomenon in some sickle cell disease patients. Many sickle cell patients require regular blood transfusions. After a red blood cell transfusion, hemoglobin levels typically increase and taper off gradually over time. Hyperhemolysis is a life-threatening reaction to blood transfusions in sickle cell patients where instead of staying increased, hemoglobin increases briefly, then crashes lower than even the initial level. This can happen within a matter of hours, and with further transfusions it can happen repeatedly.  

“We don’t know why this happens to some patients, so I’m working to figure out this mechanism,” says Dr. Branch. “If we know why and how this happens, maybe we can figure out how to prevent it.”   

Read the AABB blog to learn more about Dr. Branch’s many contributions to transfusion medicine and hematology.  

Image
Dr. Donald Branch holds his award at the AABB annual meeting in San Antonio
Dr. Donald Branch holds the Tibor Greenwalt Memorial Award at the AABB annual meeting in San Antonio. (Photo: Chantale Pambrun)

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Wednesday, February 28, 2018
Dr. Kendra Hodgkinson

For this instalment of “Meet the researcher”, we met with Dr. Donald Branch, a scientist at Canadian Blood Services who studies infectious diseases and immunology. How long have you been with Canadian Blood Services? I started with the Canadian Red Cross at the Edmonton Blood Centre in December 1985...


Wednesday, February 24, 2016
Lisa Willemse

Wonder drug it may be, but IVIg is a slippery fish. Even after 60 years, little is known about precisely how it works. An encounter with a scientist The first thing you notice when you walk into Dr. Don Branch’s office at 67 College Street in Toronto is how small it seems. And colourful, owing to an...


Wednesday, June 13, 2018
Jenny Ryan

On June 5, Canadian Blood Services was honoured to accept the Canadian Operational Research Society's Omandt Solandt Award at a reception in Halifax, Nova Scotia. Michelle Rogerson, Director, Supply Chain (Atlantic), Canadian Blood Services, accepted the award on behalf of the organization. Image...

Memories of CST 2019


Thursday, October 24, 2019 Jenny Ryan

The 2019 Canadian Transplant Summit took place Oct. 15-19 in iconic Banff, Alta. Presented by the Canadian Society of Transplantation (CST), Canadian Blood Services and the Canadian Donation and Transplantation Research Program (CDTRP), this annual event is a unique opportunity to bring together medical professionals, scientists, patients and stakeholders of all interests in organ donation and transplantation from across Canada.

This community works together to foster a future which will increase access to organs, cells and tissues, and improve health outcomes for Canadians living with a transplant. The meeting was a key networking and knowledge exchange event that attracted more than 350 participants.

Highlights

As part of the opening keynote address on Oct. 16, the audience experienced two very diverse life-saving perspectives.

Winner of the 2012 Nobel Prize in Economics, Alvin Roth of Stanford University, presented the opening plenary titled “Kidney Exchange: an opportunity for cooperation in North America”, a look at the impacts of cross-border kidney sharing. Dr. Roth helped design the high school matching system used in New York City, and is one of the early founders and designers of kidney exchange in the United States, which helps incompatible patient-donor pairs find compatible kidneys for transplantation.

The parents of Logan Boulet, Toby and Bernadine, shared their perspective on organ donation and transplantation as a donor family. Logan Boulet made the decision to be an organ donor just weeks before his passing in the tragic Humboldt Broncos bus crash in April 2018. Inspired to register by his coach and mentor, Ric Suggit, who became an organ donor following his death in 2017, Logan registered his decision and took the wise and necessary step of sharing his decision with his family. 

Tweet from CST participant with photos of the Boulets presenting

 

Logan’s legacy lives on and continues to inspire Canadians to register their intent to become organ donors. The first annual Green Shirt Day was held on April 7, 2019 in Logan’s honour. This annual tribute continues to raise awareness and honour the selfless gift that is organ donation.

Bernadine and Toby Boulet share their perspective as a donor family
Bernadine and Toby Boulet share their perspective as a donor family

A number of sessions throughout the conference provided insight into the work being done in Canada and internationally to push the boundaries of ‘higher risk’ donors, and especially to increase the uptake and usage of Hepatitis C (NAT positive) donor organs for healthy waitlisted patient.

On Oct. 17, during a lunch symposium, Sean Delaney, associate director of listing and allocation at Canadian Blood Services, brought his unique perspective as both transplant professional and as a kidney recipient (a generous gift from his brother), currently on the waitlist for a second kidney. His presentation was titled “Patient perspective on the marginal or high risk offer vs. waiting for a 'better' offer.”

Delaney, based in Edmonton, Alta., was part of building the original Kidney Paired Donation (KPD) program, as well as implementing the highly sensitized patient (HSP) interprovincial kidney sharing program. Together, the programs have produced more than 1,000 transplants for Canadian patients through interprovincial sharing. Most recently, he has been working to advance heart and liver sharing through the Canadian Transplant Registry.

Photo of Sean Delaney speaking at a podium

 

 

 

Artificial intelligence and machine learning were hot topics at this meeting and the subject of a half-day workshop presented by the CDTRP.

On Oct. 19, a morning session shared further insight into living donation. Dr. John Gill with the University of British Columbia presented about costs incurred by living donors that present a barrier or disincentives to donation. Dr. Rahul Mainra, a transplant nephrologist in Saskatchewan, presented about the impact of kidney paired donation and the importance of ‘matchability’ for kidney paired donation and transplantation. Allison Hunt, who donated her left kidney to a total stranger after a snap decision made at a cocktail party, provided perspectives from an altruistic living donor.

Tweet reading . @amhealey  provided an insightful overview of DCD Hearts: A possible medical legal/ethical framework in  @cst_transplant  Heart Concurrent Session. The patient/donor family engagement that has occurred to investigate this issue is very impressive. #PatientsIncluded #CdnTxSummit2019

 

 

 

 

Kathy Yetzer, associate director of living donation with Canadian Blood Services, presented a poster about key success factors for Canadian living kidney donation transplant programs.
Kathy Yetzer, associate director of living donation with Canadian Blood Services, presented a poster about key success factors for Canadian living kidney donation transplant programs.

The poster sessions brought great insight into the wealth and breadth of research underway across the field. Kathy Yetzer, associate director of living donation with Canadian Blood Services, presented a poster about key success factors for Canadian living kidney donation transplant programs. The findings show that performance success was most influenced by implementation of living donation evaluation efficiencies; engaging program stakeholders; broadening living donation identification and awareness strategies; access to quality assurance resources; increased living kidney donation transplant funding; and operating room availability. 

Tweet reading: Thank you  @umtincka  for an outstanding talk on “Canada’s National Multiorgan Willing to Cross Strategy” - Technology, DNA and Policy/Analysis is the how!  @cst_peds   @cst_transplant  #2019CanadianTransplantSummit

 

 

 

Altogether, CST 2019 was great forum for knowledge exchange and to advance organ and tissue donation and transplantation in Canada. Kudos to the organizing teams at the Canadian Society of Transplantation, Canadian Blood Services and the Canadian Donation and Transplantation Research Program.

Learn more about CST 2019

A tweet from the summit showing animals that look like deer or caribou walking down a path

 

 

 


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Friday, November 02, 2018
Jenny Ryan

Health professionals, patients, and policy makers gathered in Ottawa to discuss the future of transplantation in Canada at the Canadian Transplant Summit 2018 — October 16-20, 2018. The Canadian Society of Transplantation, Canadian Blood Services, the Canadian Donation and Transplantation Research...


Wednesday, April 20, 2016
Michelle Hampson

Transplanting organs, tissue or stem cells from one person to another saves lives. It was not easy to figure out what facilitates a healthy and successful transplant though. Efforts over a long time reveal the complexity of the procedure and that very specific circumstances are required. As researchers’ understanding of the immune system improved, so did the success rate of transplants.


Tuesday, January 15, 2019
Jenny Ryan

Five hundred kidney transplants made possible through national highly sensitized patient program

The 2019 Critical Care Canada Forum hosts fifth annual Deceased Organ Donation Symposium


Tuesday, October 08, 2019 Jenny Ryan

This year marks the fifth annual Deceased Organ Donation Symposium at the Critical Care Canada Forum in Toronto.

Presented by Canadian Blood Services, Trillium Gift of Life and the Canadian Donation and Transplantation Research Program (CDTRP), this two-day symposium held Nov. 11–12, 2019 promotes scientific research in organ donation and transplantation and its application to critical care practice. 

Image
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Highlights from the 2019 Symposium program:

Donation after circulatory determination of death is responsible for the largest quantitative increase in deceased donation and transplantation in Canada. This year’s Deceased Donation Symposium will feature presentations on the latest research about the physiology of dying and the impact of withdrawal of life sustaining measures procedures on donation after circulatory determination of death. A panel discussion will highlight some of the tensions – old and new – that surround this type of donation.

Presumed consent In April 2019, Nova Scotia became the first jurisdiction in Canada to pass presumed consent (opt-out) legislation, designed to increase organ and tissue donation. Though countries with deemed consent models generally have higher donation rates, this consent model is only one of the many key components necessary for an optimal organ donation and transplantation system. After a presentation by Phil Walton, the United Kingdom’s deemed consent project lead, we’ll hear Canadian perspectives on what this legislation means, not only for Nova Scotia, but for the rest of the country and whether Canada is really ready for this. 

Medical assistance in dying and organ donation — The legalization of medical assistance in dying (MAID) in Canada has led to requests for donation after circulatory determination of death from patients who are conscious and competent. The 2019 Deceased Donation Symposium will look at the state of MAID and organ donation today and what it might look like in the future. A donor coordinator who, instead of speaking to substitute decision makers about donation opportunities, is speaking directly to the patient themselves, will describe how and why MAID cases are different from other DCD cases.  

A family perspective — Finally, Randy Tresidder, whose wife was the first person to undergo MAID and organ donation in Nova Scotia, will share his experience and perspectives on MAID and organ donation. The incredible story of Randy’s wife, Dr. Shelly Sarwal, is captured in the documentary film Her Last Project. CCCF attendees will have an opportunity to watch the film on Wednesday, November 13 at 12:30pm. 

https://herlastproject.files.wordpress.com/2019/09/hlp20190913_2.jpg?w=1024

About the Critical Care Canada Forum

The Critical Care Canada Forum is a four-day conference focusing on topics that are relevant to the individuals involved with the care of critically ill patients, wherever the patients are located. Internationally recognized, the Critical Care Canada Forum focuses on leading-edge science through informative and interactive sessions, led by an outstanding international faculty, with poster presentations and exhibits with the latest products and services for the critical care professional.

Did you miss last year’s event? Videos from the 2018 Deceased Donation Symposium at CCCF are available here.


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Related blog posts


Wednesday, December 20, 2017
Jenny Ryan

Canadian partners bring experts together for two-day Deceased Donation Symposium as part of CCCF


Wednesday, May 08, 2019
Jenny Ryan

Canadian Blood Services, Trillium Gift of Life Network and the Canadian Donation and Transplantation Research Program partnered to host the Deceased Organ Donation Symposium that took place at the Critical Care Canada Forum (CCCF) on November 7 – 8, 2018. The CCCF is a national forum attended by...


Tuesday, November 06, 2018
Jenny Ryan

The Critical Care Canada Forum (CCCF) takes place this week in Toronto. The annual event is attended by hundreds of health professionals working in critical care, primarily physicians. A key event within the Forum is an unopposed plenary on brain death determination, to be held on Wednesday, November 7th.

Lay Science Writing Competition open for submissions!


Tuesday, October 01, 2019 Dr. Geraldine Walsh

Stories underlie all research experiences, and we want to hear them! The 2019 Canadian Blood Services’ Lay Science Writing Competition launches today and is open for submissions until Nov. 29, 2019. This year’s theme is “Stories worth telling”. We’re delighted to once again partner with science communication and research leaders Science Borealis and the Centre for Blood Research at the University of British Columbia to host this competition. 

This is an opportunity for research trainees in the Canadian Blood Services research network, including those at UBC’s Centre for Blood Research and, new this year, the UBC School of Biomedical Engineering, to test their plain writing skills. Submissions should use clear language to describe “Stories worth telling” in the areas of blood, plasma, stem cells or organs and tissues research. Submissions will be judged not just for their clear language, but also on their use of storytelling or narrative techniques to describe the research and the story behind the research. Consider what elements make a good story. Add a human angle or other details that readers will be able to relate to. Tell us about the people behind the research, the impact of the work, the journey, the emotional highs and lows! 

The winning writer will receive a $300 prize and the two runners-up will each receive a $100 prize. Selected entries will be disseminated through the Canadian Blood Services, Science Borealis and the Centre for Blood Research's online platforms and social media channels. 

Please note, the work must be original and not previously published. Click here to access the competition guidelines and the application form. If you have questions, please contact the Centre for Innovation by email at centreforinnovation@blood.ca  

The very best of luck! 

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STORIES WORTH TELLING! Canadian Blood Services’ Centre for Innovation presents Lay Science Writing Competition 2019-20 Call for Submissions Deadline: November 29, 2019 Use plain language to tell the story of your research in blood, plasma, stem cells or organs & tissues Open to members of the Canadian Blood Services extended research trainee network Find out more at blood.ca/research/funding-opportunities

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Thursday, November 15, 2018
Jenny Ryan

Use plain language to tell the story of your research in blood, plasma, stem cells or organs & tissues.


Friday, April 05, 2019
Dr. Geraldine Walsh

The results of our first-ever Lay Science Writing Competition are in, read-on to discover who gets top-prize and what happens next.


Thursday, April 18, 2019
Dr. Jennie Haw

Dr. Jennie Haw's prize-winning entry in our Lay Science Writing Competition describes research underway to optimize cord blood donor recruitment for the national, public cord blood bank.

Dr. Donna Wall wins lifetime achievement award


Friday, September 27, 2019 Catherine Lewis

With a medical career spanning almost 40 years, Dr. Donna Wall has made significant contributions to the evolution of blood and marrow transplantation across North America.

After completing paediatric and paediatric hematology/oncology training in the U.S., Dr. Wall went on to establish blood and marrow transplantation and public cord blood programs in cities including St. Louis and San Antonio. Among her many other collaborations, Dr. Wall has contributed to the transplant community upon her return to Canada. She helped launch Canadian Blood Services’ Cord Blood Bank and served on the organization’s stem cell expert advisory committee for several years.

Despite recent advances in hematopoietic stem cell transplantation, there is still a great need for improvement at the pre- and post-transplant stages. Dr. Wall’s research focuses on better understanding the immune system, with the hope of improving patient outcomes — particularly children undergoing transplant. She has also worked on early phase clinical trials exploring gene therapy for treating childhood acute leukemia.

In recognition of her achievements, Dr. Wall received Canadian Blood Services' Lifetime Achievement Award at the annual Honouring Canada's Lifeline event in Ottawa on Sept. 23. 

Dr. Wall joined The Hospital for Sick Children (SickKids) and the University of Toronto in 2016 as section head of the blood and marrow transplant/cellular therapy program. She has also chaired the hematopoietic stem cell transplant discipline in the Children’s Oncology Group and holds leadership positions in the Paediatric Blood and Marrow Transplant Group, the Canadian Blood and Marrow Transplant Group, and the CIHR-funded Canadian National Transplant Research program.

Dr. Donna Wall

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Wednesday, July 12, 2017
Jenny Ryan

July marks Cord Blood Awareness Month in certain places around the world. In homage to this important campaign we collected a few related stories from the RED archives and share a bit more information about why Cord Blood matters. Cord blood stem cells can be used in the treatment of more than 80...


Thursday, September 26, 2019
Catherine Lewis

With a focus on improving the lives of patients living with autoimmune diseases, transplant physician and scientist Dr. Harold Atkins has dedicated his career to discovering innovative methods for stem cell transplantation. In the late 1990s, Dr. Atkins and neurologist Dr. Mark Freedman proposed a...


Tuesday, July 09, 2019
Obinna Okwelume

July is Cord Blood Awareness Month. Since 2014, Canadian Blood Services, in partnership with The Ottawa Hospital, has been running a Cord Blood for Research Program to facilitate cord blood research in Canada.

Stem cell transplantation pioneer wins lifetime achievement award


Thursday, September 26, 2019 Catherine Lewis

With a focus on improving the lives of patients living with autoimmune diseases, transplant physician and scientist Dr. Harold Atkins has dedicated his career to discovering innovative methods for stem cell transplantation.

In the late 1990s, Dr. Atkins and neurologist Dr. Mark Freedman proposed a novel way to stop the progression of early aggressive multiple sclerosis (MS) by completely wiping out a patient’s immune system, followed by a stem cell transplant. Their idea was first received with skepticism by the medical community.

In 2016, however, The Lancet (one of the most prestigious peer-reviewed medical journals in the world) published their landmark study, which had followed patients for up to 13 years and demonstrated outstanding results: Atkins and Freedman had been able to achieve long-term suppression of all MS-related inflammation, most patients’ disabilities had stabilized, and some patients had even regained abilities they previously lost.

This therapeutic procedure, known as immunoablation and autologous hematopoietic stem cell transplantation (IAHSCT), continues to be studied by the medical community worldwide. Today, there is a network of physicians across the U.S. and Europe who are tracking about 1,000 IAHSCT patients. Dr. Atkins has also pioneered work using IAHSCT for two other rare autoimmune disorders: myasthenia gravis and stiff person syndrome. So far, studies have shown great promise.

Canadian Blood Services' stem cell manufacturing program supported the clinical trial, and continues to support treatments. The blood stem cells used in the clinical trial were autologous, meaning they were collected from the participants themselves. Canadian Blood Services staff on site at the Ottawa Hospital collected the stem cells (mobilized from the bone marrow into the blood and collected by an apheresis procedure), and then shipped them to Canadian Blood Services’ stem cell manufacturing facility for processing.

In recognition for his achievements, Dr. Atkins received Canadian Blood Services' Lifetime Achievement Award at the annual Honouring Canada's Lifeline event in Ottawa on Sept. 23. 

In addition to his work as a physician at the Ottawa Hospital Blood and Marrow Transplant Program, Dr. Atkins is an associate professor of medicine at the University of Ottawa, a scientist in the Centre for Innovative Cancer Research and the medical director of the Regenerative Medicine Program at the Ottawa Hospital Research Institute.

Dr. Harold Atkins

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

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Tuesday, June 21, 2016
Veronica Magee

On June 9, The Ottawa Hospital announced an exciting breakthrough treatment for some MS patients. The clinical trial, supported by our autologous stem cell program, was just published in The Lancet and has received world-wide media attention.


Thursday, November 09, 2017
Jennifer Ciavaglia

The James Kreppner Award Program supports legal research relevant to Canadian Blood Services. This year’s award competition closes November 30.


Wednesday, April 06, 2016
Veronica Magee

Led by The Ottawa Hospital, a groundbreaking trial called Cellular Immunotherapy for Septic Shock is testing the idea that mesenchymal stem cells may be able to help control the body’s immune system to reduce injury and promote healing, while improving its ability to fight infection.