Our Funded Research Projects

Updated November 2018

Title Principal Investigator / Supervisor Program Project Start Date Sort descending Project End Date Total $ Awarded
The use of antibody-mediated immune suppression as a model in the development of a replacement for RhD prophylaxis in haemolytic disease of the fetus and newborn Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program $620,822
Towards the impact of protein synthesis in human platelets to transfusion medicine Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: BOSGOED, Christa
Graduate Fellowship Program $92,000
Role of skin disinfection and buffy coat platelet production on residual bacterial contamination in platelet concentrates and cord blood stem cells Principal Investigator: RAMIREZ, Sandra

Co-Investigator(s) / Trainee: TAHA, Mariam
Graduate Fellowship Program $92,000
Studies on the development of biocompatible antimicrobial platelet storage devices Principal Investigator: BROOKS, Don

Co-Investigator(s) / Trainee: HADJESFANDIARI, Narges
Graduate Fellowship Program $96,000
Transfusion requirements in cardiac surgery (TRICS II) Principal Investigator: SHEHATA, Nadine

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership New Investigator Program $300,000
Assessment of fluorinated ice crystallization inhibitors: cryopreservation of hematopoietic stem cells and red blood cells Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: BRIARD, Jennie
Graduate Fellowship Program $96,000
Pathogenesis of fetal and neonatal alloimmune thrombocytopenia and mechanisms of IVIG therapy Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee: YOUGBARE, Issaka
Postdoctoral Fellowship Program $151,800
The in vivo effects of liposome treatment on minimizing membrance injury in rat red blood cells during hypothermic storage Principal Investigator: HOLOVATI, Jelena

Co-Investigator(s) / Trainee: da SILVIERA CAVALCANTE, Luciana
Graduate Fellowship Program $100,000
Identification of protein biomarkers for red cell quality Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: CHEN, Deborah
Graduate Fellowship Program $100,000
Development of novel blood vessel and organ sealants for blood conservation in surgical practice Principal Investigator: BROOKS, Don

Co-Investigator(s) / Trainee: DU, Caigan , HSIANG, York N. , KIZHAKKEDATHU, Jayachandran N. , KO, Frank K.
Canadian Blood Services-CIHR Partnership Operating Grant Program $240,996
The Canadian National Transplant Research Program: increasing donating and improving transplantation outcomes Principal Investigator: WEST, Lori

Co-Investigator(s) / Trainee:
Transplantation Research Program $250,000
Improving the cryostorage of blood products using novel small molecule cryoprotectants Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: ACKER, Jason P. , ALLAN, David S.
Canadian Blood Services-CIHR Partnership Operating Grant Program $384,180
Transfusion-related Epstein-Barr Virus (EBV) infection among allogeneic stem cell transplant pediatric recipients: A multicenter prospective cohort study (TREASuRE Study) Principal Investigator: TROTTIER, Helen

Co-Investigator(s) / Trainee: ALFIERI, Carolina , BUTEAU, Chantal , DUVAL, Michel , LACROIX, Jacques , ROBITAILLE, Nancy , SPINELLA, Philip , TUCCI, Marisa
Canadian Blood Services-CIHR Partnership Operating Grant Program $519,766
Platelet microRNAs during storage under blood bank conditions Principal Investigator: PROVOST, Patrick

Co-Investigator(s) / Trainee: HITZLER, Walter
Canadian Blood Services-CIHR Partnership Operating Grant Program $349,548
Small molecule inhibitors of phagocytosis as replacement therapy for IVIG Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: KOTRA, Lakshmi, P.
Canadian Blood Services-CIHR Partnership Operating Grant Program $409,127
Transfusion of red cells in hematopoietic stem cell transplantation: The TRIST Study Principal Investigator: TAY, Jason

Co-Investigator(s) / Trainee: ALLAN, David S. , COYLE, Douglas A. , FERGUSSON, Dean A. , TINMOUTH, Alan T. , WALKER, Irwin R
Canadian Blood Services-CIHR Partnership Operating Grant Program $340,817
MRI guided focused ultrasound facilitated IVIg immunotherapy as a therapeutic approach for Alzheimer's disease Principal Investigator: AUBERT, Isabelle

Co-Investigator(s) / Trainee: DUBEY, Sonam
Graduate Fellowship Program $100,000
Residual risk of transfusion-transmitted cytomegalovirus infection: incidence and pathogenesis Principal Investigator: PREIKSAITIS, Jutta

Co-Investigator(s) / Trainee: O'BRIEN, Sheila F., FEARON, Margaret, NAHIRNIAK, Susan
Intramural Research Grant Program $260,451
Characterization of the role of MSI2 in human hematopoietic stem cell self-renewal Principal Investigator: HOPE, Kristin

Co-Investigator(s) / Trainee: RENTAS, Stefan
Graduate Fellowship Program $100,000
Antibodies to CD44 as a potential replacement for IVIg in ITP Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: SEMPLE, John W., SHEFFIELD, William
Intramural Research Grant Program $300,000
Characterization of the hematopoietic reconstitution enhancing activity of osteoblasts derived from human mesenchymal stromal cells Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: CAMPBELL, Pearl , GARNIER, Alain
Canadian Blood Services-CIHR Partnership Operating Grant Program $320,504
The Centre for Blood Research Principal Investigator: CONWAY, Ed

Co-Investigator(s) / Trainee:
Program Support Award for Canadian Transfusion Medicine and Science Research Program $776,229
Understanding host mechanisms responsible for immune platelet destruction and thrombocytopenia Principal Investigator: SEMPLE, John

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program $406,003
Role of Fc receptors in antibody-mediated immune suppression Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: BERNARDO REYES, Lidice
Postdoctoral Fellowship Program $106,200
McMaster Transfusion Research Program Principal Investigator: HEDDLE, Nancy

Co-Investigator(s) / Trainee:
Program Support Award for Canadian Transfusion Medicine and Science Research Program $833,333
Design and implementation of circulatory oxygen therapeutics derived from human hemoglobin by improved systematic chemical coupling and cross-linking Principal Investigator: KLUGER, Ronald

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program $192,039
Polyhemoglobin catalase superoxide dismutase carbonic anhydrase: a novel soluble biotherapeutic with no cardiac toxicity for hemorrhagic shock and other uses Principal Investigator: CHANG, Thomas

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program $224,520
University of Ottawa Centre for Transfusion Research Principal Investigator: TINMOUTH, Alan

Co-Investigator(s) / Trainee:
Program Support Award for Canadian Transfusion Medicine and Science Research Program $799,888
Tranexamic acid versus placebo to reduce perioperative blood transfusion in patients undergoing major liver resection: a pilot randomized controlled trial Principal Investigator: KARANICOLAS, Paul

Co-Investigator(s) / Trainee: GUYATT, Gordon H. , CHAUDHURY, Prosanto K. , DIXON, Elijah , LIN, Yulia , McCLUSKEY, Stuart A. , PORTER, Geoffrey A. , TARSHIS, Jordan , WEI, Alice C.
Canadian Blood Services-CIHR Partnership Operating Grant Program $248,319
Investigation of pathophysiology, prevention and treatment of murine Transfusion Related Acute Lung Injury (TRALI) Principal Investigator: SEMPLE, John

Co-Investigator(s) / Trainee: McVEY, Mark
Graduate Fellowship Program $52,000
Cellular therapy to improve CD4+ T-Cell responses in humanized mice infected with HIV-1: adoptive transfer of CD4+ T-cells lacking s-Src activity Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: McCARTHY, Stephen
Graduate Fellowship Program $96,000
Impact of storage on the function of cord blood hematopoietic stem and progenitor cells Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: JAHAN, Suria
Graduate Fellowship Program $104,000
Pathogenesis and treatment of immune thrombocytopenia: Are there fundamental differences between anti-GPlba- and anti-GPllbllla-mediated thrombocytopenia? Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership Operating Grant Program $378,529
Microfluidic devices to measure the deformability of stored red blood cells Principal Investigator: MA, Hongshen

Co-Investigator(s) / Trainee: SCOTT, Mark D.
Canadian Blood Services-CIHR Partnership Operating Grant Program $398,301
Exploratory analyses to determine if method of donor blood processing affects outcome in transfused recipients Principal Investigator: HEDDLE, Nancy

Co-Investigator(s) / Trainee: ACKER, Jason P. , ARNOLD, Donald M. , COOK, Richard J. , EIKELBOOM, John W. , O'BRIEN, Sheila F. , WEBERT, Kathryn E.
Canadian Blood Services-CIHR Partnership Operating Grant Program $159,878
Mechanisms of antibody-independent transfusion-related acute lung injury (TRALI) Principal Investigator: KUEBLER, Wolfgang

Co-Investigator(s) / Trainee: SEMPLE, John W.
Canadian Blood Services-CIHR Partnership Operating Grant Program $328,712
Elucidation of the mechanism of IVIG-associated hemolysis Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: PENDERGRAST, Jacob , CSERTI-GAZDEWICH, Christine , SHEHATA, Nadine , PAVENSKI, Katerina , LAU, Wendy , CALLUM, Jeannie , LIN, Yulia , LIEBERMAN, Lani , HANNACH, Barbara
Intramural Research Grant Program $393,712
Understanding transcriptional and epigenetic control by Gfi1b towards the development of a therapy for sickle cell disease Principal Investigator: TRUDEL, Marie

Co-Investigator(s) / Trainee: MOROY, Tarik
Canadian Blood Services-CIHR Partnership Operating Grant Program $453,132
Understanding brain death: a multipurpose educational video aimed to a diverse public and professional audience Principal Investigator: SHEMIE, Sam

Co-Investigator(s) / Trainee:
Small Project Funding Program $14,000
Release, delivery and cell programming effects of platelet microparticles and microRNAs Principal Investigator: PROVOST, Patrick

Co-Investigator(s) / Trainee: BOILARD, Eric
Canadian Blood Services-CIHR Partnership Operating Grant Program $427,422
Legal and policy strategies to optimize organ donation in Alberta Principal Investigator: TOEWS, Maeghan

Co-Investigator(s) / Trainee:
James Kreppner Fellowship Program $150,000
Short and long-term clinical effects of blood donor characteristics in transfusion recipients Principal Investigator: FERGUSSON, Dean

Co-Investigator(s) / Trainee: ACKER, Jason P., CHASSÉ, Michael, ENGLISH, Shane, FORSTER, Alan, KNOLL, Greg, McINTYRE, Lauralyn A., SHEHATA, Nadine , van WALRAVEN, Carl, WILSON, Kumanan , TINMOUTH, Alan T.
Canadian Blood Services-CIHR Partnership Operating Grant Program $103,806
Defining the components of transfusable plasma that reduce bleeding Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: PRYZDIAL, Edward, NI, Heyu
Intramural Research Grant Program $218,230
Mechanism of anti-D-like antibody-mediated amelioration of immune thrombocytopenia (ITP) Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: YU, Xiaojie (Ben)
Postdoctoral Fellowship Program $106,200
Code sepsis: defining and translating optimal resuscitation and care for children with septic shock Principal Investigator: PARKER, Melissa

Co-Investigator(s) / Trainee:
Canadian Blood Services-CIHR Partnership New Investigator Program $300,000
Transfusion options in coagulopathy: efficacy in controlling bleeding Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: QADRI, Syed
Postdoctoral Fellowship Program $151,800
Understanding IVIg mechanism(s) of action in alleviating immune platelet destruction and thrombocytopenia Principal Investigator: SEMPLE, John

Co-Investigator(s) / Trainee: KAPUR, Ricky
Postdoctoral Fellowship Program $106,200
Understanding the factors that influence bacterial proliferation and biofilm formation in platelet concentrates Principal Investigator: RAMIREZ, Sandra

Co-Investigator(s) / Trainee: LOZA CORREA, Maria
Postdoctoral Fellowship Program $151,800
Small molecule inhibitors of phagocytosis to replace intravenous immunoglobulin (IVIG) Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: TONG, Tik Nga (Cindy)
Graduate Fellowship Program $52,000
Prospective observational study of organ deceased donor management in 3 ICUs - a pilot study (the DONATE pilot study) Principal Investigator: MEADE, Maureen

Co-Investigator(s) / Trainee: D'ARAGON, Frederick, RIBIC, Christine, SHARPE, Michael, BALL, Ian, WILLIAMSON, David, DHANANI, Sonny, HANNA, Steven
Kenneth J. Fyke Award Program $89,555
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