Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium Jimenez-Diaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O'Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, Endsley AN, Fedewa G, Guiguemde WA, Gomez MG, Holbrook G, Horst J, Kim CC, Liu J, Lee MC, Matheny A, Martinez MS, Miller G, Rodriguez-Alejandre A, Sanz L, Sigal M, Spillman NJ, Stein PD, Wang Z, Zhu F, Waterson D, Knapp S, Shelat A, Avery VM, Fidock DA, Gamo FJ, Charman SA, Mirsalis JC, Ma H, Ferrer S, Kirk K, Angulo-Barturen I, Kyle DE, DeRisi JL, Floyd DM, Guy RK 2014 PNAS Researchers Basic research
[Influence of Anticoagulants on Detection of ITP Platelet-Specific Autoantibodies and Relationship of Autoantibody Types with Glucocorticoid Efficacy] Chen Y, Ge J, Ruan M, Zhu L-Y, Zeng Q-S, Xia R-X, Ni H 2015 Zhongguo shi yan xue ye xue za zhi Researchers Basic research
[Study on the relationship of platelet specific-autoantibodies with therapeutic outcomes by dexamethasone in immune thrombocytopenia purpura] Chen Y, Ge J, Ruan M, Zhu L, Xie Y, Xia R, Ni H, Zeng Q 2015 Zhonghua Xue Ye Xue Za Zhi Researchers Clinical research
2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium Spitalnik SL, Triulzi D, Devine DV, Dzik WH, Eder AF, Gernsheimer T, Josephson CD, Kor DJ, Luban NLC, Roubinian NH, Mondoro T, Welniak LA, Zou S, Glynn S, for the State of the Science in Transfusion Medicine Working G 2015 Transfusion Other Other
2-HG inhibits necroptosis by stimulating DNMT1-dependent hypermethylation of the RIP3 promoter Yang Z, Jiang B, Wang Y, Ni H, Zhang J, Xia J, Shi M, Hung L, Ruan J, Mak T, Li Q, Han J 2017 Cell Rep Researchers Basic research
A 13-question approach to resolving serological discrepancies in the transfusion medicine laboratory Yudin J, Heddle NM 2014 Lab Med Health care providers Clinical research
A benchmarking program to reduce red blood cell outdating: implementation, evaluation, and a conceptual framework Barty RL, Gagliardi K, Owens W, Lauzon D, Scheuermann S, Liu Y, Wang G, Pai M, Heddle NM 2015 Transfusion Health care providers Benchmarking and standard setting
A biochemical network can control formation of a synthetic material by sensing numerous specific stimuli Hun Yeon J, Chan KYT, Wong T-C, Chan K, Sutherland MR, Ismagilov RF, Pryzdial ELG, Kastrup CJ 2015 Sci Rep Researchers Basic research
A bioinformatics approach to identify natural autoantibodies from healthy blood donors' sera reactive with the HCV NS5A-derived peptide by immunoassay Vasiljevic N, Veljkovic N, Kosec T, Ma XZ, Glisic S, Prljic J, Vujicic AD, Markovic L, Branch DR 2011 Viral Immunol Researchers Basic research
A blinded study of bone marrow examinations in patients with primary immune thrombocytopenia Mahabir VK, Ross C, Popovic S, Sur ML, Bourgeois J, Lim W, George JN, Wang G, Cook RJ, Toltl LJ, Nazi I, Kelton JG, Arnold DM 2013 Eur J Haematol Health care providers Clinical research
A brief survey of clinicians' perceptions of parent preferences for involvement in obstetrical and perinatal management decisions in haemophilia Lucier KJ, Movilla RV, Parvizian MK, Siddiqui R, Gabriele EH, Bourque M, MacIsaac J, Moorehead PC, Chan AK, Heddle NM, Lane SJ 2018 Haemophilia Health care providers Clinical research
A case of vertical transmission of Chagas Disease contracted via blood transfusion in Canada Fearon MA, Scalia V, Huang M, Dines I, Ndao M 2013 Can J Infect Dis Med Microbiol Health care providers Clinical research
A clinical governance framework for blood services Williamson LM, Benjamin RJ, Devine DV, Katz LM, Pink J, for the Alliance of Blood Operators Medical Directors Group 2015 Vox Sang Blood operators Other
A Comparative Study of McFarland Turbidity Standards and the Densimat Photometer to Determine Bacterial Cell Density Zapata A, Ramirez-Arcos S 2015 Curr Microbiol Blood operators New or improved product or process
A flow cytometric method for platelet counting in platelet concentrates van der Meer PF, Karssing-van Leeuwen W, Kurtz J, Spengler H-P, Blair A, Devine D, Harrison P, Lambrecht B, VandenBroeke T, de Wildt J, de Korte D, on behalf of the Biomedical Excellence for Safer Transfusion C 2012 Transfusion Researchers New or improved product or process
A fresh look at measuring quality in blood components Devine DV, Chen D 2014 ISBT Sci Ser Blood operators Other
A generic modelling framework to evaluate network blood management policies: The Canadian Blood Services experience Blake JT, Hardy M 2014 Oper Res Health Care Blood operators New or improved product or process
A Guide to Reporting Adverse Transfusion Events Canadian Blood Services 2014 Blood.ca website Health care providers Other
A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP) Kapur R, Catalina MD, Aslam R, Speck ER, Francovitch RF, Semple JW 2017 Br J Haematol Researchers Basic research
A lab-on-chip for malaria diagnosis and surveillance Taylor BJ, Howell A, Martin KA, Manage DP, Gordy W, Campbell SD, Lam S, Jin A, Polley SD, Samuel RA, Atrazhev A, Stickel AJ, Birungi J, Mbonye AK, Pilarski LM, Acker JP, Yanow SK 2014 Malar J Researchers Basic research
A large national study of ferritin testing in Canadian blood donors Goldman M, Uzicanin S, Osmond L, Scalia V, O'Brien SF 2017 Transfusion Blood operators Clinical research
A method to measure permeability of red blood cell membrane to water and solutes using intrinsic fluorescence Zhurova M, Olivieri A, Holt A, Acker JP 2014 Clin Chim Acta Researchers Basic research
A monoclonal antibody with anti-D–like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects Yu X, Menard M, Seabright G, Crispin M, Lazarus AH 2015 Transfusion Researchers Basic research
A Mother and Newborn with Brown Blood Estey MP, Clarke G, Sia W, Toor E, Higgins TN 2015 Clin Chem Health care providers Clinical research
A multicentred study to validate a consensus bleeding assessment tool developed by the biomedical excellence for safer transfusion collaborative for use in patients with haematological malignancy Dyer C, Alquist CR, Cole-Sinclair M, Curnow E, Dunbar NM, Estcourt LJ, Kaufman R, Kutner JM, McCullough J, McQuilten Z, Potiphar L, Rioux-Masse B, Slichter S, Tinmouth A, Webert K, Yokoyama AP, Stanworth SJ 2018 Vox Sang Health care providers Clinical research
A new diagnosis of Addison's disease with a twist Alhabib M, McAssey K, Parker MJ 2016 J Endocrinol Diabetes Health care providers Clinical research
A new tool to assess bleeding severity in patients with chemotherapy-induced thrombocytopenia (CME) Webert KE, Arnold DM, Lui Y, Carruthers J, Arnold E, Heddle NM 2012 Transfusion Health care providers Clinical research
A novel compensating mechanism for homozygous coagulation factor V deficiency suggested by enhanced activated partial thromboplastin time after reconstitution with normal factor V Talbot K, Song J, Hewitt J, Serrano K, Ho M, Carter CJ, MacGillivray RTA, Pryzdial ELG 2010 Br J Haematol Researchers Basic research
A novel nanobiotherapeutic poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] with no cardiac toxicity for the resuscitation of a rat model with 90 minutes of sustained severe hemorrhagic shock with loss of 2/3 blood volume Bian Y, Chang TM 2015 Artif Cells Nanomed Biotechnol Researchers Basic research
A novel VSV/HIV pseudotype approach for the study of HIV microbicides without requirement for level 3 biocontainment Harrison AL, Henry S, Mahfoud R, Manis A, Albertini A, Gaudin Y, Lingwood CA, Branch DR 2011 Future Virol Researchers Basic research
A pH and thermosensitive choline phosphate-based delivery platform targeted to the acidic tumor microenvironment Yu X, Yang X, Horte S, Kizhakkedathu JN, Brooks DE 2014 Biomaterials Researchers Basic research
A phase-II sequential case-series study of all patients presenting to four plasma exchange centres with presumed relapsed/refractory thrombotic thrombocytopenic purpura treated with rituximab Clark WF, Rock G, Barth D, Arnold DM, Webert KE, Yenson PR, Kelton JG, Li L, Foley SR, members of the Canadian Apheresis G 2015 Br J Haematol Health care providers Clinical research
A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models Sheffield WP, Eltringham-Smith LJ, Gataiance S, Bhakta V 2014 J Thromb Thrombolysis Researchers Basic research
A platelet cover-up Arnold DM 2013 Blood Researchers Other
A prospective study measuring the development of antibodies against platelet factor 4-heparin in healthy males after exposure to heparins Kelton JG, Warkentin TE, Moore JC, Arnold DM, Nazi I, Arepally GM, Roach JM, Fier I 2012 J Thromb Haemost Health care providers Clinical research
A quality monitoring program for red blood cell components: in vitro quality indicators before and after implementation of semiautomated processing Acker JP, Hansen AL, Kurach JD, Turner TR, Croteau I, Jenkins C 2014 Transfusion Blood operators Benchmarking and standard setting
A randomized controlled trial comparing the outcome of critically ill adults who received fresher vs. older red cells units Lacroix J, Hébert PC, Fergusson DA, Tinmouth A, Walsh T, Stanworth S, Campbell H, Boyd J, Burrows H, Hemmatapour S, on behalf of the Canadian Critical Care Trials Group 2016 ISBT Sci Ser Health care providers Clinical research
A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus McCarthy SDS, Majchrzak-Kita B, Racine T, Kozlowski HN, Baker DP, Hoenen T, Kobinger GP, Fish EN, Branch DR 2016 PLoS Negl Trop Dis Researchers Basic research
A role for red cell clearance in antibody-mediated inhibition of erythrocyte alloimmunization? Marjoram D, Cruz-Leal Y, Bernardo L, Lazarus AH 2017 ISBT Sci Ser Researchers Basic research
A single-institution analysis of the utility of pre-induction ejection fraction measurement in patients newly diagnosed with acute myeloid leukemia Bryant A, Sheppard D, Sabloff M, Delbaere M, Maze R, Allan D, Atkins H, Bence-Bruckler I, Faught C, Huebsch L, Tay J, Zanke B, Bredeson C 2015 Leuk Lymphoma Health care providers Clinical research
A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial Ypma PF, van der Meer PF, Heddle NM, van Hilten JA, Stijnen T, Middelburg RA, Hervig T, van der Bom JG, Brand A, Kerkhoffs JL 2016 BMJ Open Researchers Clinical research
A synthetic globotriaosylceramide analogue inhibits HIV-1 infection in vitro by two mechanisms Harrison AL, Olsson ML, Jones RB, Ramkumar S, Sakac D, Binnington B, Henry S, Lingwood CA, Branch DR 2010 Glycoconj J Researchers Basic research
A systematic evaluation of laboratory testing for drug-induced immune thrombocytopenia Arnold DM, Kukaswadia S, Nazi I, Esmail A, Dewar L, Smith JW, Warkentin TE, Kelton JG 2013 J Thromb Haemost Health care providers Clinical research
A systematic review of definitions and reporting of bleeding outcome measures in haemophilia Chai-Adisaksopha C, Hillis C, Thabane L, Iorio A 2015 Haemophilia Health care providers Clinical research
A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles Akyurekli C, Le Y, Richardson RB, Fergusson D, Tay J, Allan DS 2015 Stem Cell Rev Health care providers Clinical research
A thermoreversible poly(choline phosphate) based universal biomembrane adhesive Yu X, Yang X, Horte S, Kizhakkedathu JN, Brooks DE 2014 Macromol Biosci Researchers Basic research
A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial Parker MJ, Thabane L, Fox-Robichaud A, Liaw P, Choong K 2016 Trials Researchers Clinical research
AABB Committee Report: reducing transfusion-transmitted cytomegalovirus infections AABB Clinical Transfusion Medicine Committee, Heddle NM, Boeckh M, Grossman B, Jacobson J, Kleinman S, Tobian AAR, Webert K, Wong ECC, Roback JD 2016 Transfusion Blood operators Clinical research
ABO blood groups influence macrophage-mediated phagocytosis of Plasmodium falciparum-infected erythrocytes Wolofsky KT, Ayi K, Branch DR, Hult AK, Olsson ML, Liles WC, Cserti-Gazdewich CM, Kain KC 2012 PLoS Pathog Researchers Basic research
ABO zygosity, but not secretor or Fc receptor status, is a significant risk factor for IVIG-associated hemolysis Branch DR, Hellberg Å, Bruggeman CW, Storry JR, Sakac D, Blacquiere M, Tong TN, Burke-Murphy E, Binnington B, Parmar N, Riden LS, Willie K, Armali C, Aziz J, Lieberman L, Laroche V, Callum J, Lin Y, Shehata N, Pavenski K, Lau W, Hannach B, Kuijpers TW, Olsson ML, Cserti-Gazdewich C, Pendergrast J 2018 Blood Health care providers Clinical research