Our Research Publications
Updated November 2023
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Title | Authors | Year | Journal | Link to Article | Intended Audience | Purpose |
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(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium | Jimenez-Diaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O'Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, Endsley AN, Fedewa G, Guiguemde WA, Gomez MG, Holbrook G, Horst J, Kim CC, Liu J, Lee MC, Matheny A, Martinez MS, Miller G, Rodriguez-Alejandre A, Sanz L, Sigal M, Spillman NJ, Stein PD, Wang Z, Zhu F, Waterson D, Knapp S, Shelat A, Avery VM, Fidock DA, Gamo FJ, Charman SA, Mirsalis JC, Ma H, Ferrer S, Kirk K, Angulo-Barturen I, Kyle DE, DeRisi JL, Floyd DM, Guy RK | 2014 | PNAS | View (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium | Researchers | Basic research |
[Influence of Anticoagulants on Detection of ITP Platelet-Specific Autoantibodies and Relationship of Autoantibody Types with Glucocorticoid Efficacy] | Chen Y, Ge J, Ruan M, Zhu L-Y, Zeng Q-S, Xia R-X, Ni H | 2015 | Zhongguo shi yan xue ye xue za zhi | View [Influence of Anticoagulants on Detection of ITP Platelet-Specific Autoantibodies and Relationship of Autoantibody Types with Glucocorticoid Efficacy] | Researchers | Basic research |
[Study on the relationship of platelet specific-autoantibodies with therapeutic outcomes by dexamethasone in immune thrombocytopenia purpura] | Chen Y, Ge J, Ruan M, Zhu L, Xie Y, Xia R, Ni H, Zeng Q | 2015 | Zhonghua Xue Ye Xue Za Zhi | View [Study on the relationship of platelet specific-autoantibodies with therapeutic outcomes by dexamethasone in immune thrombocytopenia purpura] | Researchers | Clinical research |
2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium | Spitalnik SL, Triulzi D, Devine DV, Dzik WH, Eder AF, Gernsheimer T, Josephson CD, Kor DJ, Luban NLC, Roubinian NH, Mondoro T, Welniak LA, Zou S, Glynn S, for the State of the Science in Transfusion Medicine Working G | 2015 | Transfusion | View 2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium | Other | Other |
2-HG inhibits necroptosis by stimulating DNMT1-dependent hypermethylation of the RIP3 promoter | Yang Z, Jiang B, Wang Y, Ni H, Zhang J, Xia J, Shi M, Hung L, Ruan J, Mak T, Li Q, Han J | 2017 | Cell Rep | View 2-HG inhibits necroptosis by stimulating DNMT1-dependent hypermethylation of the RIP3 promoter | Researchers | Basic research |
A 13-question approach to resolving serological discrepancies in the transfusion medicine laboratory | Yudin J, Heddle NM | 2014 | Lab Med | View A 13-question approach to resolving serological discrepancies in the transfusion medicine laboratory | Health care providers | Clinical research |
A benchmarking program to reduce red blood cell outdating: implementation, evaluation, and a conceptual framework | Barty RL, Gagliardi K, Owens W, Lauzon D, Scheuermann S, Liu Y, Wang G, Pai M, Heddle NM | 2015 | Transfusion | View A benchmarking program to reduce red blood cell outdating: implementation, evaluation, and a conceptual framework | Health care providers | Benchmarking and standard setting |
A biochemical network can control formation of a synthetic material by sensing numerous specific stimuli | Hun Yeon J, Chan KYT, Wong T-C, Chan K, Sutherland MR, Ismagilov RF, Pryzdial ELG, Kastrup CJ | 2015 | Sci Rep | View A biochemical network can control formation of a synthetic material by sensing numerous specific stimuli | Researchers | Basic research |
A bioinformatics approach to identify natural autoantibodies from healthy blood donors' sera reactive with the HCV NS5A-derived peptide by immunoassay | Vasiljevic N, Veljkovic N, Kosec T, Ma XZ, Glisic S, Prljic J, Vujicic AD, Markovic L, Branch DR | 2011 | Viral Immunol | View A bioinformatics approach to identify natural autoantibodies from healthy blood donors' sera reactive with the HCV NS5A-derived peptide by immunoassay | Researchers | Basic research |
A blinded study of bone marrow examinations in patients with primary immune thrombocytopenia | Mahabir VK, Ross C, Popovic S, Sur ML, Bourgeois J, Lim W, George JN, Wang G, Cook RJ, Toltl LJ, Nazi I, Kelton JG, Arnold DM | 2013 | Eur J Haematol | View A blinded study of bone marrow examinations in patients with primary immune thrombocytopenia | Health care providers | Clinical research |
A brief survey of clinicians' perceptions of parent preferences for involvement in obstetrical and perinatal management decisions in haemophilia | Lucier KJ, Movilla RV, Parvizian MK, Siddiqui R, Gabriele EH, Bourque M, MacIsaac J, Moorehead PC, Chan AK, Heddle NM, Lane SJ | 2018 | Haemophilia | View A brief survey of clinicians' perceptions of parent preferences for involvement in obstetrical and perinatal management decisions in haemophilia | Health care providers | Clinical research |
A case of vertical transmission of Chagas Disease contracted via blood transfusion in Canada | Fearon MA, Scalia V, Huang M, Dines I, Ndao M | 2013 | Can J Infect Dis Med Microbiol | View A case of vertical transmission of Chagas Disease contracted via blood transfusion in Canada | Health care providers | Clinical research |
A clinical governance framework for blood services | Williamson LM, Benjamin RJ, Devine DV, Katz LM, Pink J, for the Alliance of Blood Operators Medical Directors Group | 2015 | Vox Sang | View A clinical governance framework for blood services | Blood operators | Other |
A Comparative Study of McFarland Turbidity Standards and the Densimat Photometer to Determine Bacterial Cell Density | Zapata A, Ramirez-Arcos S | 2015 | Curr Microbiol | View A Comparative Study of McFarland Turbidity Standards and the Densimat Photometer to Determine Bacterial Cell Density | Blood operators | New or improved product or process |
A flow cytometric method for platelet counting in platelet concentrates | van der Meer PF, Karssing-van Leeuwen W, Kurtz J, Spengler H-P, Blair A, Devine D, Harrison P, Lambrecht B, VandenBroeke T, de Wildt J, de Korte D, on behalf of the Biomedical Excellence for Safer Transfusion C | 2012 | Transfusion | View A flow cytometric method for platelet counting in platelet concentrates | Researchers | New or improved product or process |
A fresh look at measuring quality in blood components | Devine DV, Chen D | 2014 | ISBT Sci Ser | View A fresh look at measuring quality in blood components | Blood operators | Other |
A generic modelling framework to evaluate network blood management policies: The Canadian Blood Services experience | Blake JT, Hardy M | 2014 | Oper Res Health Care | View A generic modelling framework to evaluate network blood management policies: The Canadian Blood Services experience | Blood operators | New or improved product or process |
A Guide to Reporting Adverse Transfusion Events | Canadian Blood Services | 2014 | Blood.ca website | View A Guide to Reporting Adverse Transfusion Events | Health care providers | Other |
A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP) | Kapur R, Catalina MD, Aslam R, Speck ER, Francovitch RF, Semple JW | 2017 | Br J Haematol | View A highly purified form of staphylococcal protein A alleviates murine immune thrombocytopenia (ITP) | Researchers | Basic research |
A lab-on-chip for malaria diagnosis and surveillance | Taylor BJ, Howell A, Martin KA, Manage DP, Gordy W, Campbell SD, Lam S, Jin A, Polley SD, Samuel RA, Atrazhev A, Stickel AJ, Birungi J, Mbonye AK, Pilarski LM, Acker JP, Yanow SK | 2014 | Malar J | View A lab-on-chip for malaria diagnosis and surveillance | Researchers | Basic research |
A large national study of ferritin testing in Canadian blood donors | Goldman M, Uzicanin S, Osmond L, Scalia V, O'Brien SF | 2017 | Transfusion | View A large national study of ferritin testing in Canadian blood donors | Blood operators | Clinical research |
A method to measure permeability of red blood cell membrane to water and solutes using intrinsic fluorescence | Zhurova M, Olivieri A, Holt A, Acker JP | 2014 | Clin Chim Acta | View A method to measure permeability of red blood cell membrane to water and solutes using intrinsic fluorescence | Researchers | Basic research |
A monoclonal antibody with anti-D–like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects | Yu X, Menard M, Seabright G, Crispin M, Lazarus AH | 2015 | Transfusion | View A monoclonal antibody with anti-D–like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects | Researchers | Basic research |
A Mother and Newborn with Brown Blood | Estey MP, Clarke G, Sia W, Toor E, Higgins TN | 2015 | Clin Chem | View A Mother and Newborn with Brown Blood | Health care providers | Clinical research |
A multicentred study to validate a consensus bleeding assessment tool developed by the biomedical excellence for safer transfusion collaborative for use in patients with haematological malignancy | Dyer C, Alquist CR, Cole-Sinclair M, Curnow E, Dunbar NM, Estcourt LJ, Kaufman R, Kutner JM, McCullough J, McQuilten Z, Potiphar L, Rioux-Masse B, Slichter S, Tinmouth A, Webert K, Yokoyama AP, Stanworth SJ | 2018 | Vox Sang | View A multicentred study to validate a consensus bleeding assessment tool developed by the biomedical excellence for safer transfusion collaborative for use in patients with haematological malignancy | Health care providers | Clinical research |
A new diagnosis of Addison's disease with a twist | Alhabib M, McAssey K, Parker MJ | 2016 | J Endocrinol Diabetes | View A new diagnosis of Addison's disease with a twist | Health care providers | Clinical research |
A new tool to assess bleeding severity in patients with chemotherapy-induced thrombocytopenia (CME) | Webert KE, Arnold DM, Lui Y, Carruthers J, Arnold E, Heddle NM | 2012 | Transfusion | View A new tool to assess bleeding severity in patients with chemotherapy-induced thrombocytopenia (CME) | Health care providers | Clinical research |
A novel compensating mechanism for homozygous coagulation factor V deficiency suggested by enhanced activated partial thromboplastin time after reconstitution with normal factor V | Talbot K, Song J, Hewitt J, Serrano K, Ho M, Carter CJ, MacGillivray RTA, Pryzdial ELG | 2010 | Br J Haematol | View A novel compensating mechanism for homozygous coagulation factor V deficiency suggested by enhanced activated partial thromboplastin time after reconstitution with normal factor V | Researchers | Basic research |
A novel nanobiotherapeutic poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] with no cardiac toxicity for the resuscitation of a rat model with 90 minutes of sustained severe hemorrhagic shock with loss of 2/3 blood volume | Bian Y, Chang TM | 2015 | Artif Cells Nanomed Biotechnol | View A novel nanobiotherapeutic poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] with no cardiac toxicity for the resuscitation of a rat model with 90 minutes of sustained severe hemorrhagic shock with loss of 2/3 blood volume | Researchers | Basic research |
A novel VSV/HIV pseudotype approach for the study of HIV microbicides without requirement for level 3 biocontainment | Harrison AL, Henry S, Mahfoud R, Manis A, Albertini A, Gaudin Y, Lingwood CA, Branch DR | 2011 | Future Virol | View A novel VSV/HIV pseudotype approach for the study of HIV microbicides without requirement for level 3 biocontainment | Researchers | Basic research |
A pH and thermosensitive choline phosphate-based delivery platform targeted to the acidic tumor microenvironment | Yu X, Yang X, Horte S, Kizhakkedathu JN, Brooks DE | 2014 | Biomaterials | View A pH and thermosensitive choline phosphate-based delivery platform targeted to the acidic tumor microenvironment | Researchers | Basic research |
A phase-II sequential case-series study of all patients presenting to four plasma exchange centres with presumed relapsed/refractory thrombotic thrombocytopenic purpura treated with rituximab | Clark WF, Rock G, Barth D, Arnold DM, Webert KE, Yenson PR, Kelton JG, Li L, Foley SR, members of the Canadian Apheresis G | 2015 | Br J Haematol | View A phase-II sequential case-series study of all patients presenting to four plasma exchange centres with presumed relapsed/refractory thrombotic thrombocytopenic purpura treated with rituximab | Health care providers | Clinical research |
A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models | Sheffield WP, Eltringham-Smith LJ, Gataiance S, Bhakta V | 2014 | J Thromb Thrombolysis | View A plasmin-activatable thrombin inhibitor reduces experimental thrombosis and assists experimental thrombolysis in murine models | Researchers | Basic research |
A platelet cover-up | Arnold DM | 2013 | Blood | View A platelet cover-up | Researchers | Other |
A prospective study measuring the development of antibodies against platelet factor 4-heparin in healthy males after exposure to heparins | Kelton JG, Warkentin TE, Moore JC, Arnold DM, Nazi I, Arepally GM, Roach JM, Fier I | 2012 | J Thromb Haemost | View A prospective study measuring the development of antibodies against platelet factor 4-heparin in healthy males after exposure to heparins | Health care providers | Clinical research |
A quality monitoring program for red blood cell components: in vitro quality indicators before and after implementation of semiautomated processing | Acker JP, Hansen AL, Kurach JD, Turner TR, Croteau I, Jenkins C | 2014 | Transfusion | View A quality monitoring program for red blood cell components: in vitro quality indicators before and after implementation of semiautomated processing | Blood operators | Benchmarking and standard setting |
A randomized controlled trial comparing the outcome of critically ill adults who received fresher vs. older red cells units | Lacroix J, Hébert PC, Fergusson DA, Tinmouth A, Walsh T, Stanworth S, Campbell H, Boyd J, Burrows H, Hemmatapour S, on behalf of the Canadian Critical Care Trials Group | 2016 | ISBT Sci Ser | View A randomized controlled trial comparing the outcome of critically ill adults who received fresher vs. older red cells units | Health care providers | Clinical research |
A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus | McCarthy SDS, Majchrzak-Kita B, Racine T, Kozlowski HN, Baker DP, Hoenen T, Kobinger GP, Fish EN, Branch DR | 2016 | PLoS Negl Trop Dis | View A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus | Researchers | Basic research |
A role for red cell clearance in antibody-mediated inhibition of erythrocyte alloimmunization? | Marjoram D, Cruz-Leal Y, Bernardo L, Lazarus AH | 2017 | ISBT Sci Ser | View A role for red cell clearance in antibody-mediated inhibition of erythrocyte alloimmunization? | Researchers | Basic research |
A single-institution analysis of the utility of pre-induction ejection fraction measurement in patients newly diagnosed with acute myeloid leukemia | Bryant A, Sheppard D, Sabloff M, Delbaere M, Maze R, Allan D, Atkins H, Bence-Bruckler I, Faught C, Huebsch L, Tay J, Zanke B, Bredeson C | 2015 | Leuk Lymphoma | View A single-institution analysis of the utility of pre-induction ejection fraction measurement in patients newly diagnosed with acute myeloid leukemia | Health care providers | Clinical research |
A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial | Ypma PF, van der Meer PF, Heddle NM, van Hilten JA, Stijnen T, Middelburg RA, Hervig T, van der Bom JG, Brand A, Kerkhoffs JL | 2016 | BMJ Open | View A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial | Researchers | Clinical research |
A synthetic globotriaosylceramide analogue inhibits HIV-1 infection in vitro by two mechanisms | Harrison AL, Olsson ML, Jones RB, Ramkumar S, Sakac D, Binnington B, Henry S, Lingwood CA, Branch DR | 2010 | Glycoconj J | View A synthetic globotriaosylceramide analogue inhibits HIV-1 infection in vitro by two mechanisms | Researchers | Basic research |
A systematic evaluation of laboratory testing for drug-induced immune thrombocytopenia | Arnold DM, Kukaswadia S, Nazi I, Esmail A, Dewar L, Smith JW, Warkentin TE, Kelton JG | 2013 | J Thromb Haemost | View A systematic evaluation of laboratory testing for drug-induced immune thrombocytopenia | Health care providers | Clinical research |
A systematic review of definitions and reporting of bleeding outcome measures in haemophilia | Chai-Adisaksopha C, Hillis C, Thabane L, Iorio A | 2015 | Haemophilia | View A systematic review of definitions and reporting of bleeding outcome measures in haemophilia | Health care providers | Clinical research |
A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles | Akyurekli C, Le Y, Richardson RB, Fergusson D, Tay J, Allan DS | 2015 | Stem Cell Rev | View A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles | Health care providers | Clinical research |
A thermoreversible poly(choline phosphate) based universal biomembrane adhesive | Yu X, Yang X, Horte S, Kizhakkedathu JN, Brooks DE | 2014 | Macromol Biosci | View A thermoreversible poly(choline phosphate) based universal biomembrane adhesive | Researchers | Basic research |
A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial | Parker MJ, Thabane L, Fox-Robichaud A, Liaw P, Choong K | 2016 | Trials | View A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial | Researchers | Clinical research |
AABB Committee Report: reducing transfusion-transmitted cytomegalovirus infections | AABB Clinical Transfusion Medicine Committee, Heddle NM, Boeckh M, Grossman B, Jacobson J, Kleinman S, Tobian AAR, Webert K, Wong ECC, Roback JD | 2016 | Transfusion | View AABB Committee Report: reducing transfusion-transmitted cytomegalovirus infections | Blood operators | Clinical research |
ABO blood groups influence macrophage-mediated phagocytosis of Plasmodium falciparum-infected erythrocytes | Wolofsky KT, Ayi K, Branch DR, Hult AK, Olsson ML, Liles WC, Cserti-Gazdewich CM, Kain KC | 2012 | PLoS Pathog | View ABO blood groups influence macrophage-mediated phagocytosis of Plasmodium falciparum-infected erythrocytes | Researchers | Basic research |
ABO zygosity, but not secretor or Fc receptor status, is a significant risk factor for IVIG-associated hemolysis | Branch DR, Hellberg Å, Bruggeman CW, Storry JR, Sakac D, Blacquiere M, Tong TN, Burke-Murphy E, Binnington B, Parmar N, Riden LS, Willie K, Armali C, Aziz J, Lieberman L, Laroche V, Callum J, Lin Y, Shehata N, Pavenski K, Lau W, Hannach B, Kuijpers TW, Olsson ML, Cserti-Gazdewich C, Pendergrast J | 2018 | Blood | View ABO zygosity, but not secretor or Fc receptor status, is a significant risk factor for IVIG-associated hemolysis | Health care providers | Clinical research |