Research

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Our Funded Research Projects

Updated December 2017

Displaying 1 - 50 of 109.
E.g., 2017-12-16
E.g., 2017-12-16
Project Investigator(s) Program Start Datesort descending End Date Total $ Awarded
The use of antibody-mediated immune suppression as a model in the development of a replacement for RhD prophylaxis in haemolytic disease of the fetus and newborn Principal Investigator:
LAZARUS, Alan
St. Michael's Hospital
Canadian Blood Services-CIHR Partnership Operating Grant Program Mar 1, 2011 Feb 20, 2017 $620,822
Towards the impact of protein synthesis in human platelets to transfusion medicine Principal Investigator:
DEVINE, Dana
University of British Columbia

Co-Investigator(s) / Trainee:
BOSGOED, Christa
Graduate Fellowship Program Aug 1, 2011 May 30, 2016 $92,000
Role of skin disinfection and buffy coat platelet production on residual bacterial contamination in platelet concentrates and cord blood stem cells Principal Investigator:
RAMIREZ, Sandra
University of Ottawa

Co-Investigator(s) / Trainee:
TAHA, Mariam
Graduate Fellowship Program Nov 15, 2011 May 14, 2016 $92,000
Studies on the development of biocompatible antimicrobial platelet storage devices Principal Investigator:
BROOKS, Don
University of British Columbia

Co-Investigator(s) / Trainee:
HADJESFANDIARI, Narges
Graduate Fellowship Program Feb 1, 2012 Jan 31, 2016 $96,000
Transfusion requirements in cardiac surgery (TRICS II) Principal Investigator:
SHEHATA, Nadine
St. Michael's Hospital
Canadian Blood Services-CIHR Partnership New Investigator Program Apr 1, 2012 Mar 31, 2017 $300,000
Assessment of fluorinated ice crystallization inhibitors: cryopreservation of hematopoietic stem cells and red blood cells Principal Investigator:
BEN, Robert
University of Ottawa

Co-Investigator(s) / Trainee:
BRIARD, Jennie
Graduate Fellowship Program Sep 1, 2012 Aug 31, 2016 $96,000
Pathogenesis of fetal and neonatal alloimmune thrombocytopenia and mechanisms of IVIG therapy Principal Investigator:
NI, Heyu
St. Michael's Hospital

Co-Investigator(s) / Trainee:
YOUGBARE, Issaka
Postdoctoral Fellowship Program Oct 1, 2012 Sep 30, 2016 $151,800
The in vivo effects of liposome treatment on minimizing membrance injury in rat red blood cells during hypothermic storage Principal Investigator:
HOLOVATI, Jelena
University of Alberta

Co-Investigator(s) / Trainee:
da SILVIERA CAVALCANTE, Luciana
Graduate Fellowship Program Feb 1, 2013 Jan 31, 2017 $100,000
Identification of protein biomarkers for red cell quality Principal Investigator:
DEVINE, Dana
University of British Columbia

Co-Investigator(s) / Trainee:
CHEN, Deborah
Graduate Fellowship Program Feb 1, 2013 Jan 31, 2017 $100,000
Transfusion-related Epstein-Barr Virus (EBV) infection among allogeneic stem cell transplant pediatric recipients: A multicenter prospective cohort study (TREASuRE Study) Principal Investigator:
TROTTIER, Helen
Hopital Sainte-Justine

Co-Investigator(s) / Trainee:
ALFIERI, Carolina
BUTEAU, Chantal
DUVAL, Michel
LACROIX, Jacques
ROBITAILLE, Nancy
SPINELLA, Philip
TUCCI, Marisa
Canadian Blood Services-CIHR Partnership Operating Grant Program Apr 1, 2013 Jun 30, 2017 $519,766
Improving the cryostorage of blood products using novel small molecule cryoprotectants Principal Investigator:
BEN, Robert
University of Ottawa

Co-Investigator(s) / Trainee:
ACKER, Jason P.
ALLAN, David S.
Canadian Blood Services-CIHR Partnership Operating Grant Program Apr 1, 2013 Mar 31, 2017 $384,180
The Canadian National Transplant Research Program: increasing donating and improving transplantation outcomes Principal Investigator:
WEST, Lori
University of Alberta
Transplantation Research Program Apr 1, 2013 Mar 31, 2018 $250,000
Small molecule inhibitors of phagocytosis as replacement therapy for IVIG Principal Investigator:
BRANCH, Donald
St. Michael's Hospital

Co-Investigator(s) / Trainee:
KOTRA, Lakshmi, P.
Canadian Blood Services-CIHR Partnership Operating Grant Program Apr 1, 2013 Mar 31, 2016 $409,127
Development of novel blood vessel and organ sealants for blood conservation in surgical practice Principal Investigator:
BROOKS, Don
University of British Columbia

Co-Investigator(s) / Trainee:
DU, Caigan
HSIANG, York N.
KIZHAKKEDATHU, Jayachandran N.
KO, Frank K.
Canadian Blood Services-CIHR Partnership Operating Grant Program Apr 1, 2013 Mar 31, 2017 $240,996
Platelet microRNAs during storage under blood bank conditions Principal Investigator:
PROVOST, Patrick
University of Laval

Co-Investigator(s) / Trainee:
HITZLER, Walter
Canadian Blood Services-CIHR Partnership Operating Grant Program Apr 1, 2013 Sep 30, 2016 $349,548
Transfusion of red cells in hematopoietic stem cell transplantation: The TRIST Study Principal Investigator:
TAY, Jason
Ottawa Hospital Research Institute

Co-Investigator(s) / Trainee:
ALLAN, David S.
COYLE, Douglas A.
FERGUSSON, Dean A.
TINMOUTH, Alan T.
WALKER, Irwin R
Canadian Blood Services-CIHR Partnership Operating Grant Program Apr 1, 2013 Mar 31, 2016 $340,817
MRI guided focused ultrasound facilitated IVIg immunotherapy as a therapeutic approach for Alzheimer's disease Principal Investigator:
AUBERT, Isabelle
University of Toronto

Co-Investigator(s) / Trainee:
DUBEY, Sonam
Graduate Fellowship Program May 1, 2013 Apr 30, 2017 $100,000
Characterization of the role of MSI2 in human hematopoietic stem cell self-renewal Principal Investigator:
HOPE, Kristin
McMaster University

Co-Investigator(s) / Trainee:
RENTAS, Stefan
Graduate Fellowship Program Sep 1, 2013 Aug 31, 2017 $100,000
Residual risk of transfusion-transmitted cytomegalovirus infection: incidence and pathogenesis Principal Investigator:
PREIKSAITIS, Jutta
University of Alberta

Co-Investigator(s) / Trainee:
O'BRIEN, Sheila F.
FEARON, Margaret
NAHIRNIAK, Susan
Intramural Research Grant Program Sep 1, 2013 Jun 30, 2016 $260,451
Antibodies to CD44 as a potential replacement for IVIg in ITP Principal Investigator:
LAZARUS, Alan
St. Michael's Hospital

Co-Investigator(s) / Trainee:
SEMPLE, John W.
SHEFFIELD, William
Intramural Research Grant Program Nov 1, 2013 Oct 31, 2016 $300,000
The Centre for Blood Research Principal Investigator:
CONWAY, Ed
University of British Columbia
Program Support Award for Canadian Transfusion Medicine and Science Research Program Apr 1, 2014 Jul 31, 2017 $776,229
Design and implementation of circulatory oxygen therapeutics derived from human hemoglobin by improved systematic chemical coupling and cross-linking Principal Investigator:
KLUGER, Ronald
University of Toronto
Canadian Blood Services-CIHR Partnership Operating Grant Program Apr 1, 2014 Sep 30, 2017 $192,039
Tranexamic acid versus placebo to reduce perioperative blood transfusion in patients undergoing major liver resection: a pilot randomized controlled trial Principal Investigator:
KARANICOLAS, Paul
Sunnybrook Research Institute

Co-Investigator(s) / Trainee:
GUYATT, Gordon H.
CHAUDHURY, Prosanto K.
DIXON, Elijah
LIN, Yulia
McCLUSKEY, Stuart A.
PORTER, Geoffrey A.
TARSHIS, Jordan
WEI, Alice C.
Canadian Blood Services-CIHR Partnership Operating Grant Program Apr 1, 2014 Mar 31, 2017 $248,319
Understanding host mechanisms responsible for immune platelet destruction and thrombocytopenia Principal Investigator:
SEMPLE, John
St. Michael's Hospital
Canadian Blood Services-CIHR Partnership Operating Grant Program Apr 1, 2014 Mar 31, 2017 $406,003
McMaster Transfusion Research Program Principal Investigator:
HEDDLE, Nancy
McMaster University
Program Support Award for Canadian Transfusion Medicine and Science Research Program Apr 1, 2014 Jul 31, 2017 $833,333
Polyhemoglobin catalase superoxide dismutase carbonic anhydrase: a novel soluble biotherapeutic with no cardiac toxicity for hemorrhagic shock and other uses Principal Investigator:
CHANG, Thomas
McGill University
Canadian Blood Services-CIHR Partnership Operating Grant Program Apr 1, 2014 Mar 31, 2018 $224,520
University of Ottawa Centre for Transfusion Research Principal Investigator:
TINMOUTH, Alan
Ottawa Hospital Research Institute
Program Support Award for Canadian Transfusion Medicine and Science Research Program Apr 1, 2014 Jul 31, 2017 $799,888
Characterization of the hematopoietic reconstitution enhancing activity of osteoblasts derived from human mesenchymal stromal cells Principal Investigator:
PINEAULT, Nicolas
Canadian Blood Services

Co-Investigator(s) / Trainee:
CAMPBELL, Pearl
GARNIER, Alain
Canadian Blood Services-CIHR Partnership Operating Grant Program Apr 1, 2014 Mar 31, 2018 $320,504
Role of Fc receptors in antibody-mediated immune suppression Principal Investigator:
LAZARUS, Alan
St. Michael's Hospital

Co-Investigator(s) / Trainee:
BERNARDO REYES, Lidice
Postdoctoral Fellowship Program Apr 1, 2014 Mar 18, 2016 $106,200
Investigation of pathophysiology, prevention and treatment of murine Transfusion Related Acute Lung Injury (TRALI) Principal Investigator:
SEMPLE, John
University of Toronto

Co-Investigator(s) / Trainee:
McVEY, Mark
Graduate Fellowship Program Sep 1, 2014 Aug 31, 2016 $52,000
Cellular therapy to improve CD4+ T-Cell responses in humanized mice infected with HIV-1: adoptive transfer of CD4+ T-cells lacking s-Src activity Principal Investigator:
BRANCH, Donald
University of Toronto

Co-Investigator(s) / Trainee:
McCARTHY, Stephen
Graduate Fellowship Program Sep 1, 2014 Mar 31, 2017 $96,000
Impact of storage on the function of cord blood hematopoietic stem and progenitor cells Principal Investigator:
PINEAULT, Nicolas
University of Ottawa

Co-Investigator(s) / Trainee:
JAHAN, Suria
Graduate Fellowship Program Sep 26, 2014 Dec 31, 2018 $104,000
Legal and policy strategies to optimize organ donation in Alberta Principal Investigator:
TOEWS, Maeghan
University of Alberta
James Kreppner Fellowship Program Oct 1, 2014 Sep 30, 2016 $150,000
Short and long-term clinical effects of blood donor characteristics in transfusion recipients Principal Investigator:
FERGUSSON, Dean
Ottawa Hospital Research Institute

Co-Investigator(s) / Trainee:
ACKER, Jason P.
CHASSÉ, Michael
ENGLISH, Shane
FORSTER, Alan
KNOLL, Greg
McINTYRE, Lauralyn A.
SHEHATA, Nadine
van WALRAVEN, Carl
WILSON, Kumanan
TINMOUTH, Alan T.
Canadian Blood Services-CIHR Partnership Operating Grant Program Oct 1, 2014 Sep 30, 2016 $103,806
Release, delivery and cell programming effects of platelet microparticles and microRNAs Principal Investigator:
PROVOST, Patrick
University of Laval

Co-Investigator(s) / Trainee:
BOILARD, Eric
Canadian Blood Services-CIHR Partnership Operating Grant Program Oct 1, 2014 Mar 31, 2018 $427,422
Exploratory analyses to determine if method of donor blood processing affects outcome in transfused recipients Principal Investigator:
HEDDLE, Nancy
McMaster University

Co-Investigator(s) / Trainee:
ACKER, Jason P.
ARNOLD, Donald M.
COOK, Richard J.
EIKELBOOM, John W.
O'BRIEN, Sheila F.
WEBERT, Kathryn E.
Canadian Blood Services-CIHR Partnership Operating Grant Program Oct 1, 2014 Jun 30, 2017 $159,878
Understanding brain death: a multipurpose educational video aimed to a diverse public and professional audience Principal Investigator:
SHEMIE, Sam
McGill University
Small Project Funding Program Oct 1, 2014 Sep 30, 2015 $14,000
Microfluidic devices to measure the deformability of stored red blood cells Principal Investigator:
MA, Hongshen
University of British Columbia

Co-Investigator(s) / Trainee:
SCOTT, Mark D.
Canadian Blood Services-CIHR Partnership Operating Grant Program Oct 1, 2014 Sep 30, 2018 $398,301
Understanding transcriptional and epigenetic control by Gfi1b towards the development of a therapy for sickle cell disease Principal Investigator:
TRUDEL, Marie
Institut de recherches cliniques do Montreal

Co-Investigator(s) / Trainee:
MOROY, Tarik
Canadian Blood Services-CIHR Partnership Operating Grant Program Oct 1, 2014 Sep 30, 2018 $453,132
Pathogenesis and treatment of immune thrombocytopenia: Are there fundamental differences between anti-GPlba- and anti-GPllbllla-mediated thrombocytopenia? Principal Investigator:
NI, Heyu
St. Michael's Hospital
Canadian Blood Services-CIHR Partnership Operating Grant Program Oct 1, 2014 Sep 30, 2017 $378,529
Elucidation of the cechanism of IVIG-associated hemolysis Principal Investigator:
BRANCH, Donald
Canadian Blood Services

Co-Investigator(s) / Trainee:
PENDERGRAST, Jacob
CSERTI-GAZDEWICH, Christine
SHEHATA, Nadine
PAVENSKI, Katerina
LAU, Wendy
CALLUM, Jeannie
LIN, Yulia
LIEBERMAN, Lani
HANNACH, Barbara
Intramural Research Grant Program Oct 1, 2014 Oct 31, 2017 $393,712
Mechanisms of antibody-independent transfusion-related acute lung injury (TRALI) Principal Investigator:
KUEBLER, Wolfgang
St. Michael's Hospital

Co-Investigator(s) / Trainee:
SEMPLE, John W.
Canadian Blood Services-CIHR Partnership Operating Grant Program Oct 1, 2014 Sep 30, 2018 $328,712
Defining the components of transfusable plasma that reduce bleeding Principal Investigator:
SHEFFIELD, William
McMaster University

Co-Investigator(s) / Trainee:
PRYZDIAL, Edward
NI, Heyu
Intramural Research Grant Program Nov 1, 2014 Feb 28, 2017 $218,230
Mechanism of anti-D-like antibody-mediated amelioration of immune thrombocytopenia (ITP) Principal Investigator:
LAZARUS, Alan
St. Michael's Hospital

Co-Investigator(s) / Trainee:
YU, Xiaojie (Ben)
Postdoctoral Fellowship Program Nov 3, 2014 May 11, 2016 $106,200
Code sepsis: defining and translating optimal resuscitation and care for children with septic shock Principal Investigator:
PARKER, Melissa
McMaster University
Canadian Blood Services-CIHR Partnership New Investigator Program Jan 1, 2015 Dec 31, 2019 $300,000
Transfusion options in coagulopathy: efficacy in controlling bleeding Principal Investigator:
SHEFFIELD, William
McMaster University

Co-Investigator(s) / Trainee:
QADRI, Syed
Postdoctoral Fellowship Program Jan 2, 2015 Jan 1, 2018 $151,800
Understanding IVIg mechanism(s) of action in alleviating immune platelet destruction and thrombocytopenia Principal Investigator:
SEMPLE, John
University of Toronto

Co-Investigator(s) / Trainee:
KAPUR, Ricky
Postdoctoral Fellowship Program Jan 12, 2015 Jan 11, 2017 $106,200
Understanding the factors that influence bacterial proliferation and biofilm formation in platelet concentrates Principal Investigator:
RAMIREZ, Sandra
University of Ottawa

Co-Investigator(s) / Trainee:
LOZA CORREA, Maria
Postdoctoral Fellowship Program Jan 15, 2015 Jan 14, 2018 $151,800
Small molecule inhibitors of phagocytosis to replace intravenous immunoglobulin (IVIG) Principal Investigator:
BRANCH, Donald
University of Toronto

Co-Investigator(s) / Trainee:
TONG, Tik Nga (Cindy)
Graduate Fellowship Program Feb 1, 2015 Nov 30, 2016 $52,000