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Neonatal outcomes after transfusion of ABO non-identical blood (Neo-ABO)

Principal Investigator / Supervisor: 
SOLH, Ziad
Co-Investigator(s) / Trainee: 
COOK, Richard J.
FUSCH, Christoph
McMaster University
Project Start Date: 
September 1, 2016
Project End Date: 
August 31, 2017
Routine practice in many Neonatal Intensive Care Units (NICUs) is to transfuse only group O red blood cells (RBCs). The McMaster Centre for Transfusion Research (MCTR) reported an increased risk of in-hospital mortality for adult group A patients transfused group O RBCs, raising the hypothesis that O blood may be harmful to some ABO group non-identical patients. We hypothesize that transfusing O blood to A, B and AB neonates is associated with higher rates of mortality and transfusion-associated necrotizing enterocolitis (TA-NEC) compared to group O neonates. The objectives are to: 1) create a neonatal transfusion database by linking data from 2 existing large databases: a transfusion database, and the Canadian Neonatal Network (CNN) database; 2) determine the rates of neonatal mortality and TA-NEC by the patient’s ABO blood type, and explore the association between these mortality and TA-NEC outcomes and ABO non-identical RBC transfusions. This retrospective cohort study will include very low birth weight (VLBW) neonates in the Level III NICU at McMaster Children’s Hospital (2002 to 2016). Study group: A, B and AB neonates transfused O RBCs. Control group: O neonates transfused O RBCs. Primary outcome: in-hospital mortality. Secondary outcome: TA-NEC rate.
Total Amount Awarded: 
Small Project Funding Program

Projects summaries are contributed by investigators who receive financial support from Canadian Blood Services. The summaries are intended to inform the public of the types of research projects that are supported by our organization. The information described in project summaries should not be considered as recommendation for clinical treatment and diagnosis.