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Improving pathogen inactivation: the dengue virus-induced platelet proteome

Principal Investigator / Supervisor: 
PRYZDIAL, Ed
Co-Investigator(s) / Trainee: 
TEGEGN, Tseday Zewdu
Institution: 
University of British Columbia
Province: 
British Columbia
Project Start Date: 
October 24, 2016
Project End Date: 
October 23, 2018
Summary: 
Canada’s tainted blood tragedy of the 1980’s lead to a myriad of costly tests for potential viruses (and other pathogens) in our blood products. While it was the best option available, this extensive testing is unable to insure safety from emerging and unknown risks. There is now a method to universally inactivate all pathogens potentially contaminating blood products. This pro-active approach, known as pathogen reduction technology (PRT), is being applied successfully to the liquid component of blood, called plasma. However, PRT for blood products that contain cells, like platelets, has yet to be perfected. The current research proposal addresses the molecular basis of one of the problems, which is how platelets protect certain viruses from PRT. Using dengue virus as a model known to be protected by platelets, we will evaluate how platelet proteins are changed in response to simultaneous virus and PRT treatment. This will not only provide insight into how the platelet is protecting the virus, suggesting ways to overcome this problem, but will also help to understand the severe sickness dengue virus causes around the globe. As PRT is further developed, it is will further enhance our blood system safety and reduce healthcare costs.
Total Amount Awarded: 
$52,000
Program: 
Graduate Fellowship Program

Projects summaries are contributed by investigators who receive financial support from Canadian Blood Services. The summaries are intended to inform the public of the types of research projects that are supported by our organization. The information described in project summaries should not be considered as recommendation for clinical treatment and diagnosis.