HLA Disease Association – HLA-B27, HLA-A, HLA-B, HLA-DR, HLA-DQ Pharmacogenomic Testing – HLA-B*57:01

Test description

Autoimmune Association – HLA-B27,  HLA-A, HLA-B, HLA-DR, HLA-DQ 
Under normal conditions the immune system is able to tolerate cells carrying “self” HLA antigens. However, in some cases specific inherited HLA antigens have been associated with a variety of autoimmune diseases. While not diagnostic in nature, the presence or absence of specific HLA antigens, in conjunction with clinical findings, aid the physician in making a diagnosis.

Pharmacogenomic Testing – HLA-B*57:01
This molecular test for the HLA-B*57:01 allele assists physicians in identifying patients who are at risk of developing a reaction to Abacavir. The drug Abacavir is used as a therapy for treating HIV infection and is linked to an adverse effect which can be severe and potentially life threatening. Abacavir-induced hypersensitivity reaction has been associated with the presence of the HLA-B*57:01 allele.

HLA Disease Association NPIRL (PDF)

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Specimen and requisition requirements

Specimen(s):
One (1) full 5-7 ml EDTA (lavender) tube mixed thoroughly by gentle agitation.

Label specimen with the required minimum information: patient’s last name, first name, PHN/ (PHIN) or hospital number or other unique identifier, date of collection, and facility name.

Complete requisition (must include):

  • Patient's last name, first name, date of birth and PHN/(PHIN) or hospital number or other unique identifier 
  • Facility Name
  • Physician/Health Care Provider name
  • Phlebotomist name, classification, initial
  • Date/time  of collection
  • Name, facility, address, contact number of individual to whom the report will be sent

Requisition

Platelet Immunology Requisition (PDF)
(Electronic Fillable Form)

Pre-shipping storage

Refrigerated 1-10oC.
DO NOT open EDTA samples.

Shipping instructions

Submit samples as soon as possible after collection.

Shipping
Ship in a container with an ice pack (gel pack stored at 2-8°C may be used for refrigerated samples).
Select shipping method for container to arrive at testing site within 24 hours.

Fax shipping information (way bill #) to 204-789-1186. Indicate the patient name and type of investigation on the fax.

Send to 

Canadian Blood Services
Winnipeg Centre
National Platelet Immunology Reference Laboratory (NPIRL)
777 William Ave.
Winnipeg, MB R3E 3R4
T: 204-789-1152
F: 204-789-1186